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De Soto

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De Soto Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, May 20 - Wed, Jun 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, just found
$56
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, May 20 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $56 just found
Frontier Airlines
Tue, Jun 2 - Wed, Jun 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$66 Roundtrip, found 2 hours ago
$66
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 17, priced at $66 found 2 hours ago
Frontier Airlines
Tue, Jun 2 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$67 Roundtrip, found 2 hours ago
$67
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $67 found 2 hours ago
Frontier Airlines
Sat, May 2 - Mon, May 11
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$68 Roundtrip, found 8 hours ago
$68
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Sat, May 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, May 11, priced at $68 found 8 hours ago
Frontier Airlines
Tue, Jun 2 - Tue, Jun 9
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 9 hours ago
$88
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Jun 9, priced at $88 found 9 hours ago
Frontier Airlines
Sat, May 9 - Fri, May 15
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 6 hours ago
$117
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Sat, May 9 from Denver Intl. to Lambert-St. Louis Intl., returning Fri, May 15, priced at $117 found 6 hours ago
American Airlines
Tue, May 12 - Wed, May 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$119 Roundtrip, found 4 hours ago
$119
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, May 12 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, May 13, priced at $119 found 4 hours ago
Delta
Wed, Apr 29 - Tue, May 5
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 2 hours ago
$137
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Apr 29 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Tue, May 5, priced at $137 found 2 hours ago
Frontier Airlines
Thu, Apr 30 - Wed, May 13
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$153 Roundtrip, found 23 hours ago
$153
Roundtrip
found 23 hours ago
Select Frontier Airlines flight, departing Thu, Apr 30 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Wed, May 13, priced at $153 found 23 hours ago
United
Tue, May 12 - Wed, May 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$153 Roundtrip, found 4 hours ago
$153
Roundtrip
found 4 hours ago
Select United flight, departing Tue, May 12 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, May 13, priced at $153 found 4 hours ago
Frontier Airlines
Tue, May 12 - Wed, May 27
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, May 12 from San Francisco Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $199 found 1 day ago
Frontier Airlines
Tue, Jun 16 - Tue, Jun 16
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 1 day ago
$210
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Jun 16 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $210 found 1 day ago
Delta
Tue, Jun 9 - Wed, Jun 10
DAL
Love Field
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 2 hours ago
$257
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Jun 9 from Love Field to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $257 found 2 hours ago
Frontier Airlines
Thu, Apr 23 - Fri, May 22
SJC
Norman Y. Mineta San Jose Intl.
STL
Lambert-St. Louis Intl.
$296 Roundtrip, found 1 day ago
$296
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Apr 23 from Norman Y. Mineta San Jose Intl. to Lambert-St. Louis Intl., returning Fri, May 22, priced at $296 found 1 day ago
Alaska Airlines
Wed, Apr 29 - Tue, May 12
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$327 Roundtrip, just found
$327
Roundtrip
just found
Select Alaska Airlines flight, departing Wed, Apr 29 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, May 12, priced at $327 just found
Hawaiian Airlines
Sat, Apr 11 - Tue, Apr 21
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$810 Roundtrip, found 1 day ago
$810
Roundtrip
found 1 day ago
Select Hawaiian Airlines flight, departing Sat, Apr 11 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, Apr 21, priced at $810 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$56

Last Minute Hotel Deals in De Soto

Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,009 reviews)
Nice and clean close to a lot of businesses

Reviewed on Apr 8, 2026

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Pear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,002 reviews)
I was disappointed that they had no fresh coffee in the lobby.

Reviewed on Apr 8, 2026

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Baymont Inn and Suites by Wyndham Farmington, MO
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (951 reviews)
The room was just okay. Breakfast was decent if you want a waffle or snacks (only had water and coffee for drinks). They allowed some sketchy people to hang outside in the parking lot. I don’t even think they were guests, so we worried about leaving anything in the car.

Reviewed on Apr 6, 2026

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,001 reviews)
Great experience.

Reviewed on Mar 27, 2026

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Drury Inn & Suites St. Louis Arnold
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (57 reviews)
Beautiful , comfortable!!

Reviewed on Mar 21, 2026

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Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (930 reviews)
My only complaint was that the whole building smelled like cigarettes despite it being a non smoking property

Reviewed on Apr 8, 2026

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Comfort Inn Festus - St Louis South
Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection

2.5 out of 5
4245 Hunt Rd Farmington MO
Book a stay at this golf hotel in Farmington. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (603 reviews)
Very nice.

Reviewed on Apr 7, 2026

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Crown Pointe Lodge, BW Signature Collection
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3 out of 5
1200 W. Gannon Drive Festus MO
Book a stay at this family-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jorkerst Memorial Park and Sunset ...
6.8/10 (952 reviews)
Room was clean enough, but bed was too hard. Rooms are old and in need updates. Changed rooms two times due to broken lock and then non stop barking dogs in room next to us. Last room had no hanging bar in closet so no way to keep clothes hung. Parking lot covered with litter. During the early morning, ...

Reviewed on Apr 8, 2026

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Baymont by Wyndham Festus
See all 182 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.