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De Soto

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De Soto Flights as Low as $147

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Delta
Sat, Sep 5 - Tue, Sep 15
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$147 Roundtrip, found 1 day ago
$147
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 5 from Nashville Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $147 found 1 day ago
Delta
Tue, Sep 1 - Tue, Sep 15
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$150 Roundtrip, found 1 day ago
$150
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Sep 1 from Nashville Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $150 found 1 day ago
Southern Airways Express
Mon, Sep 14 - Sun, Sep 27
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$172 Roundtrip, found 1 day ago
$172
Roundtrip
found 1 day ago
Select Southern Airways Express flight, departing Mon, Sep 14 from Nashville Intl. to Lambert-St. Louis Intl., returning Sun, Sep 27, priced at $172 found 1 day ago
Frontier Airlines
Wed, Aug 5 - Mon, Aug 10
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 5 days ago
$195
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Aug 5 from Orlando Intl. to Lambert-St. Louis Intl., returning Mon, Aug 10, priced at $195 found 5 days ago
United
Thu, Sep 3 - Sun, Sep 6
BNA
Nashville Intl.
STL
Lambert-St. Louis Intl.
$196 Roundtrip, found 1 day ago
$196
Roundtrip
found 1 day ago
Select United flight, departing Thu, Sep 3 from Nashville Intl. to Lambert-St. Louis Intl., returning Sun, Sep 6, priced at $196 found 1 day ago
Frontier Airlines
Sat, Aug 22 - Thu, Sep 10
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 1 day ago
$200
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Aug 22 from Orlando Intl. to Lambert-St. Louis Intl., returning Thu, Sep 10, priced at $200 found 1 day ago
Frontier Airlines
Mon, Aug 17 - Sun, Aug 30
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$213 Roundtrip, found 9 hours ago
$213
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Mon, Aug 17 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Sun, Aug 30, priced at $213 found 9 hours ago
Bargain Flight
Tue, Aug 11 - Tue, Aug 18
AUS
Austin-Bergstrom Intl.
STL
Lambert-St. Louis Intl.
$218 Roundtrip, found 1 day ago
$218
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Tue, Aug 11 from Austin-Bergstrom Intl. to Lambert-St. Louis Intl., returning Tue, Aug 18, priced at $218 found 1 day ago
American Airlines
Wed, Sep 9 - Tue, Sep 15
AUS
Austin-Bergstrom Intl.
STL
Lambert-St. Louis Intl.
$224 Roundtrip, found 1 day ago
$224
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 9 from Austin-Bergstrom Intl. to Lambert-St. Louis Intl., returning Tue, Sep 15, priced at $224 found 1 day ago
Frontier Airlines
Tue, Aug 4 - Wed, Aug 5
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$226 Roundtrip, found 11 hours ago
$226
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Tue, Aug 4 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Wed, Aug 5, priced at $226 found 11 hours ago
Bargain Flight
Tue, Sep 22 - Wed, Sep 23
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$231 Roundtrip, found 5 days ago
$231
Roundtrip
found 5 days ago
Select Bargain Flight flight, departing Tue, Sep 22 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Wed, Sep 23, priced at $231 found 5 days ago
Frontier Airlines
Wed, Sep 16 - Fri, Sep 18
ISP
MacArthur
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 1 day ago
$237
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Sep 16 from MacArthur to Lambert-St. Louis Intl., returning Fri, Sep 18, priced at $237 found 1 day ago
Frontier Airlines
Tue, Aug 11 - Tue, Aug 18
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$256 Roundtrip, found 9 hours ago
$256
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Tue, Aug 11 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Tue, Aug 18, priced at $256 found 9 hours ago
Frontier Airlines
Tue, Sep 22 - Sat, Oct 10
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$268 Roundtrip, found 15 hours ago
$268
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Tue, Sep 22 from San Francisco Intl. to Lambert-St. Louis Intl., returning Sat, Oct 10, priced at $268 found 15 hours ago
Bargain Flight
Wed, Jul 29 - Tue, Aug 4
ORF
Norfolk Intl.
STL
Lambert-St. Louis Intl.
$271 Roundtrip, found 15 hours ago
$271
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Wed, Jul 29 from Norfolk Intl. to Lambert-St. Louis Intl., returning Tue, Aug 4, priced at $271 found 15 hours ago
Alaska Airlines
Tue, Sep 1 - Mon, Sep 21
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$345 Roundtrip, found 15 hours ago
$345
Roundtrip
found 15 hours ago
Select Alaska Airlines flight, departing Tue, Sep 1 from San Francisco Intl. to Lambert-St. Louis Intl., returning Mon, Sep 21, priced at $345 found 15 hours ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in September, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $147, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $147 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$146

Last Minute Hotel Deals in De Soto

Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,019 reviews)
"Staff was great"

Reviewed on Jul 13, 2026

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Pear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,001 reviews)
"It took three tries for the desk clerk to get me in a room that didn’t smell awful. First room smelled like sour milk the second like someone had smoked in the room that day. The third smelled nice like air freshener. Clerk was very helpful and got me in a clean room. No compensation was offered ..."

Reviewed on Jul 13, 2026

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Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,007 reviews)
"Very nice clean hotel with large shower the breakfast was delicious"

Reviewed on Jul 9, 2026

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Drury Inn & Suites St. Louis Arnold
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (86 reviews)
"When they say tiny they mean tiny. The window view was amazing. In the middle of the woods all you see are trees. Well equipped for glamping. We enjoyed the campfire along with the peace and quiet. The Cozy and the dew drop in are close by and the food was worth the drive 🌟"

Reviewed on Jul 13, 2026

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Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,011 reviews)
"Staff was suburb Breakfast was very good could possibly had orange juice or tomato juice but overall was good. Air Conditioning was great had to turn it down as it got very cold in the room. Housekeeping was good but we did notice the floor could have been swept a little better"

Reviewed on Jul 14, 2026

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (969 reviews)
"The room was damp and smelled like mildew. The carpet in the room was wet. The hair dryer didn’t work. Outside in the hallway smelled like paint thinner or some kind of chemical very strong. We complained to the front desk about the smell and he said that they were doing some “deep cleaning “ on ..."

Reviewed on Jul 15, 2026

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Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 out of 5
1802 Gamel Cemetery Road Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (753 reviews)
"Large room. Beds were comfortable. Lots of pillows. Typical hotel breakfast. Staff kept it full. Fresh roasted coffee."

Reviewed on Jul 14, 2026

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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
WoodSpring Suites St. Louis Arnold

WoodSpring Suites St. Louis Arnold

2.5 out of 5
888 Arnold Commons Dr. Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in our ...
6.2/10 (492 reviews)
"I needed 2 pillows. You didn't have any needed more towels. Wasn't available until I turned in dirty ones. Was in shower at the time Soap machine In laundry room ate my coins. Didn't get my dollar back No change machine. But y they wer wer friendly and I think that's why the guest are friendly."

Reviewed on Jul 8, 2026

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WoodSpring Suites St. Louis Arnold
See all 193 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.