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De Soto

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De Soto Flights as Low as $72

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Aug 21 - Thu, Aug 28
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$72 Roundtrip, found 1 day ago
$72
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Aug 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Aug 28, priced at $72 found 1 day ago
Frontier Airlines
Thu, Aug 21 - Sun, Aug 31
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$112 Roundtrip, found 5 days ago
$112
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Aug 21 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Sun, Aug 31, priced at $112 found 5 days ago
Frontier Airlines
Thu, Aug 7 - Thu, Aug 14
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$120 Roundtrip, found 2 days ago
$120
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Aug 7 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Aug 14, priced at $120 found 2 days ago
Frontier Airlines
Thu, Aug 14 - Sat, Aug 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$126 Roundtrip, just found
$126
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Aug 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 16, priced at $126 just found
Spirit Airlines
Thu, Aug 14 - Sun, Aug 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$126 Roundtrip, found 5 days ago
$126
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Thu, Aug 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Aug 17, priced at $126 found 5 days ago
Delta
Thu, Oct 2 - Fri, Oct 10
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$147 Roundtrip, found 1 day ago
$147
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Oct 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 10, priced at $147 found 1 day ago
Spirit Airlines
Thu, Sep 18 - Sun, Sep 21
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$156 Roundtrip, found 1 day ago
$156
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Thu, Sep 18 from LaGuardia to Lambert-St. Louis Intl., returning Sun, Sep 21, priced at $156 found 1 day ago
American Airlines
Tue, Oct 14 - Sat, Oct 18
MKE
General Mitchell Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, found 6 days ago
$159
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Oct 14 from General Mitchell Intl. to Lambert-St. Louis Intl., returning Sat, Oct 18, priced at $159 found 6 days ago
Spirit Airlines
Sun, Aug 17 - Mon, Aug 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$169 Roundtrip, found 5 days ago
$169
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Sun, Aug 17 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Mon, Aug 18, priced at $169 found 5 days ago
United
Wed, Aug 27 - Thu, Sep 4
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 1 day ago
$176
Roundtrip
found 1 day ago
Select United flight, departing Wed, Aug 27 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $176 found 1 day ago
United
Tue, Oct 14 - Sat, Oct 18
MKE
General Mitchell Intl.
STL
Lambert-St. Louis Intl.
$183 Roundtrip, found 6 days ago
$183
Roundtrip
found 6 days ago
Select United flight, departing Tue, Oct 14 from General Mitchell Intl. to Lambert-St. Louis Intl., returning Sat, Oct 18, priced at $183 found 6 days ago
Delta
Tue, Oct 14 - Tue, Oct 21
DAL
Love Field
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 5 days ago
$197
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Oct 14 from Love Field to Lambert-St. Louis Intl., returning Tue, Oct 21, priced at $197 found 5 days ago
Delta
Thu, Sep 18 - Sun, Sep 21
JFK
John F. Kennedy Intl.
STL
Lambert-St. Louis Intl.
$201 Roundtrip, found 1 day ago
$201
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Sep 18 from John F. Kennedy Intl. to Lambert-St. Louis Intl., returning Sun, Sep 21, priced at $201 found 1 day ago
Frontier Airlines
Thu, Oct 16 - Fri, Oct 17
TTN
Mercer
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 3 days ago
$228
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Mercer to Lambert-St. Louis Intl., returning Fri, Oct 17, priced at $228 found 3 days ago
American Airlines
Tue, Aug 19 - Sun, Aug 24
AMA
Rick Husband Amarillo Intl.
STL
Lambert-St. Louis Intl.
$240 Roundtrip, found 1 day ago
$240
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Aug 19 from Rick Husband Amarillo Intl. to Lambert-St. Louis Intl., returning Sun, Aug 24, priced at $240 found 1 day ago
Spirit Airlines
Wed, Aug 6 - Sun, Aug 10
ORF
Norfolk Intl.
STL
Lambert-St. Louis Intl.
$291 Roundtrip, found 5 days ago
$291
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Wed, Aug 6 from Norfolk Intl. to Lambert-St. Louis Intl., returning Sun, Aug 10, priced at $291 found 5 days ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $72, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $72 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$72

Last Minute Hotel Deals in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
Stay at this 3.5-star family-friendly aparthotel in De Soto. Enjoy free parking, an outdoor pool, and a fitness center. Our guests praise the property condition ...
9.4/10 Exceptional! (148 reviews)
"This is my 3rd time staying here and second time as a family. and every time Ive stayed it has been clean and pleasant. Only a couple run ins with a spider and a wasp. Beyond that we have nothing to complain about and loved the bath!! We will be back again."

Reviewed on Jul 14, 2025

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Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln, Arnold, MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,016 reviews)
Formula Drift 2025
"I have to say I was pleasently suprised. 🍐 🌳 customer service from front desk, breakfast and house cleaning was AMAZING. Our room was clean and bed was comfortable. Pool outside was a nice refreshing swim when the weather was so hot. Breakfast was hot and there was somone always replenishing the ..."

Reviewed on Jul 21, 2025

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Pear Tree Inn St. Louis Arnold
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,022 reviews)
"I was very impressed with this motel. Very clean and the staff was very friendly and helpful. The breakfast was delicious!!!"

Reviewed on Jul 28, 2025

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Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141, Arnold, MO
Stay at this 3-star business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,004 reviews)
"It was a great place to stay. Free breakfast and dinner!"

Reviewed on Jul 23, 2025

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Drury Inn & Suites St. Louis Arnold
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (845 reviews)
"Great Front Desk and easy check in"

Reviewed on Jul 19, 2025

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Comfort Inn Festus - St Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd, Festus, MO
Stay at this 3-star business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (825 reviews)
"Truly amazed by the speed of check-in. The clerk on duty had her paperwork all ready, spread out on a desk. She seemed to guess which guest I was and just handed over the document to initial. Perfect efficiency! Also, she was pleasant. The lobby, stairs and hallways had been recently upgraded. Room ..."

Reviewed on Jul 21, 2025

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 out of 5
1802 Gamel Cemetery Road, Festus, MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (658 reviews)
"was a little tricky to get to, but was not right on the interstate. No Road noise at all."

Reviewed on Jul 7, 2025

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Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Postcard Cabins St. Francois

Postcard Cabins St. Francois

2 out of 5
7555 State Hwy Y, French Village, MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
10/10 Exceptional! (22 reviews)
"Even with the summer heat, don’t pass up on this opportunity. If you want something quiet, relaxing, and to just generally get away from the noise of life, give this place a weekend of your time and get exactly that in return."

Reviewed on Jul 28, 2025

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Postcard Cabins St. Francois
See all 174 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.