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De Soto

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De Soto Flights as Low as $70

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, May 19 - Wed, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$70 Roundtrip, found 1 hour ago
$70
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, May 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $70 found 1 hour ago
Frontier Airlines
Mon, May 18 - Sat, May 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$80 Roundtrip, found 2 hours ago
$80
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Mon, May 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 23, priced at $80 found 2 hours ago
Frontier Airlines
Tue, May 26 - Wed, Jun 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$93 Roundtrip, found 16 hours ago
$93
Roundtrip
found 16 hours ago
Select Frontier Airlines flight, departing Tue, May 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $93 found 16 hours ago
Frontier Airlines
Tue, May 26 - Wed, Jun 10
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$97 Roundtrip, found 2 days ago
$97
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, May 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $97 found 2 days ago
Frontier Airlines
Sat, May 9 - Fri, May 15
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$158 Roundtrip, just found
$158
Roundtrip
just found
Select Frontier Airlines flight, departing Sat, May 9 from Denver Intl. to Lambert-St. Louis Intl., returning Fri, May 15, priced at $158 just found
Delta
Wed, Jun 3 - Wed, Jun 3
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 11 hours ago
$160
Roundtrip
found 11 hours ago
Select Delta flight, departing Wed, Jun 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $160 found 11 hours ago
Frontier Airlines
Fri, May 29 - Mon, Jun 1
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 3 hours ago
$185
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Fri, May 29 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Jun 1, priced at $185 found 3 hours ago
Frontier Airlines
Tue, May 26 - Sat, May 30
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$190 Roundtrip, found 2 hours ago
$190
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, May 26 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $190 found 2 hours ago
United
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 2 hours ago
$197
Roundtrip
found 2 hours ago
Select United flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $197 found 2 hours ago
American Airlines
Wed, Aug 12 - Tue, Aug 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 2 hours ago
$197
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Aug 12 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $197 found 2 hours ago
Frontier Airlines
Sat, May 16 - Tue, May 19
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$209 Roundtrip, found 1 day ago
$209
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 16 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Tue, May 19, priced at $209 found 1 day ago
Frontier Airlines
Sat, May 9 - Tue, May 26
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 18 hours ago
$210
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sat, May 9 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Tue, May 26, priced at $210 found 18 hours ago
Delta
Sat, May 30 - Wed, Jun 10
DAL
Love Field
STL
Lambert-St. Louis Intl.
$223 Roundtrip, found 2 days ago
$223
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, May 30 from Love Field to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $223 found 2 days ago
Frontier Airlines
Tue, May 26 - Tue, Jun 9
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 1 day ago
$237
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, May 26 from LaGuardia to Lambert-St. Louis Intl., returning Tue, Jun 9, priced at $237 found 1 day ago
Delta
Tue, Jul 14 - Tue, Jul 21
SYR
Hancock Intl.
STL
Lambert-St. Louis Intl.
$291 Roundtrip, found 2 hours ago
$291
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Jul 14 from Hancock Intl. to Lambert-St. Louis Intl., returning Tue, Jul 21, priced at $291 found 2 hours ago
Alaska Airlines
Tue, May 26 - Sat, May 30
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$406 Roundtrip, found 2 hours ago
$406
Roundtrip
found 2 hours ago
Select Alaska Airlines flight, departing Tue, May 26 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $406 found 2 hours ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $70, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $70 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$70

Last Minute Hotel Deals in De Soto

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,005 reviews)
I get it is cheap, but It shouldn’t small like feet. The room smelled bad, the hallway also, the walls are thin u can hear any noise. Never again

Reviewed on Apr 26, 2026

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Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
The hotel was great. Friendly staff, clean, easy access to the building, plenty of parking. This was our first time staying with Drury and we will definitely be staying again.

Reviewed on Apr 23, 2026

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Pear Tree Inn St. Louis Arnold
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (969 reviews)
Close to stores and our final destination.

Reviewed on Apr 21, 2026

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (942 reviews)
Did have breakfast, coffee was good.

Reviewed on Apr 25, 2026

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Comfort Inn Festus - St Louis South
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,002 reviews)
The hotel itself is nice. The beds are not good.

Reviewed on Apr 23, 2026

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Drury Inn & Suites St. Louis Arnold
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (61 reviews)
Loved the smell of wood right when we entered. That huge picture window at end of cabin where bed is was spectacular. Had plenty of hot water for two people to shower one after the other. Contact with staff off site was immediate.

Reviewed on Apr 20, 2026

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Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3 out of 5
1200 W. Gannon Drive Festus MO
Book a stay at this family-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jorkerst Memorial Park and Sunset ...
6.8/10 (959 reviews)
Horrible blood stained carpet holes in door everything was grimey stay away

Reviewed on Apr 13, 2026

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Baymont by Wyndham Festus
WoodSpring Suites St. Louis Arnold

WoodSpring Suites St. Louis Arnold

2.5 out of 5
888 Arnold Commons Dr. Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in our ...
6.2/10 (481 reviews)
Overall room was good, bed was less than desirable.

Reviewed on Apr 15, 2026

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WoodSpring Suites St. Louis Arnold
See all 185 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.