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De Soto

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De Soto Flights as Low as $58

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, May 19 - Wed, May 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 5 hours ago
$58
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Tue, May 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 20, priced at $58 found 5 hours ago
Frontier Airlines
Mon, May 18 - Wed, May 20
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$74 Roundtrip, found 3 hours ago
$74
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Mon, May 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 20, priced at $74 found 3 hours ago
Frontier Airlines
Mon, May 18 - Mon, May 18
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$80 Roundtrip, found 3 hours ago
$80
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Mon, May 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, May 18, priced at $80 found 3 hours ago
Frontier Airlines
Mon, May 18 - Sat, May 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$93 Roundtrip, found 9 hours ago
$93
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Mon, May 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 23, priced at $93 found 9 hours ago
Frontier Airlines
Sat, May 30 - Thu, Jun 4
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$96 Roundtrip, just found
$96
Roundtrip
just found
Select Frontier Airlines flight, departing Sat, May 30 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Jun 4, priced at $96 just found
United
Wed, Jun 3 - Wed, Jun 3
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 2 hours ago
$140
Roundtrip
found 2 hours ago
Select United flight, departing Wed, Jun 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $140 found 2 hours ago
American Airlines
Wed, Jun 3 - Wed, Jun 3
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 2 hours ago
$140
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jun 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $140 found 2 hours ago
Frontier Airlines
Tue, May 19 - Wed, May 20
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 2 hours ago
$144
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Tue, May 19 from Detroit Metropolitan Wayne County to Lambert-St. Louis Intl., returning Wed, May 20, priced at $144 found 2 hours ago
Frontier Airlines
Sat, May 9 - Mon, May 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$158 Roundtrip, found 2 hours ago
$158
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sat, May 9 from Denver Intl. to Lambert-St. Louis Intl., returning Mon, May 11, priced at $158 found 2 hours ago
Delta
Wed, Jun 3 - Wed, Jun 3
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$160 Roundtrip, found 2 hours ago
$160
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Jun 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $160 found 2 hours ago
Frontier Airlines
Fri, May 29 - Mon, Jun 1
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 5 hours ago
$185
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Fri, May 29 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Jun 1, priced at $185 found 5 hours ago
Bargain Flight
Tue, Jun 23 - Tue, Jun 30
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$223 Roundtrip, found 16 hours ago
$223
Roundtrip
found 16 hours ago
Select Bargain Flight flight, departing Tue, Jun 23 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Tue, Jun 30, priced at $223 found 16 hours ago
Frontier Airlines
Sun, May 10 - Tue, May 26
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$226 Roundtrip, found 1 day ago
$226
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, May 10 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Tue, May 26, priced at $226 found 1 day ago
Frontier Airlines
Thu, May 14 - Sat, May 16
LAS
Harry Reid Intl.
STL
Lambert-St. Louis Intl.
$232 Roundtrip, found 5 hours ago
$232
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Thu, May 14 from Harry Reid Intl. to Lambert-St. Louis Intl., returning Sat, May 16, priced at $232 found 5 hours ago
Delta
Sat, May 30 - Sat, Jun 6
DAL
Love Field
STL
Lambert-St. Louis Intl.
$251 Roundtrip, found 3 days ago
$251
Roundtrip
found 3 days ago
Select Delta flight, departing Sat, May 30 from Love Field to Lambert-St. Louis Intl., returning Sat, Jun 6, priced at $251 found 3 days ago
Alaska Airlines
Wed, May 6 - Fri, May 29
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$443 Roundtrip, found 2 hours ago
$443
Roundtrip
found 2 hours ago
Select Alaska Airlines flight, departing Wed, May 6 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Fri, May 29, priced at $443 found 2 hours ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $58, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $58 right now, why wait?

De Soto Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$74

Last Minute Hotel Deals in De Soto

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,006 reviews)
I get it is cheap, but It shouldn’t small like feet. The room smelled bad, the hallway also, the walls are thin u can hear any noise. Never again

Reviewed on Apr 26, 2026

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Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

2.5 out of 5
1201 Drury Ln Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,003 reviews)
The hotel staff were very friendly and helpful. The room was clean but outdated. it was fine for an over night stay. the bedding was old, cheap, and uncomfortable. The plastic curtains would not close tightly and the parking lights shine directly across the bed. Take your sleep mask if staying.

Reviewed on Apr 26, 2026

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Pear Tree Inn St. Louis Arnold
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (970 reviews)
Room was clean, staff very friendly- didn’t eat the breakfast because we left early in the AM.

Reviewed on Apr 27, 2026

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

2.5 out of 5
1303 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (942 reviews)
Did have breakfast, coffee was good.

Reviewed on Apr 25, 2026

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Comfort Inn Festus - St Louis South
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

3 out of 5
3800 State Rt 141 Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.6/10 Exceptional! (1,004 reviews)
Great newer hotel. Awesome staff! They were the rock stars! The desk personnel, housekeeping staff and the food prepares were personable, kind and helpful! Oh, and the rooms are comfy, clean and spacious. Loved our stay!!

Reviewed on Apr 27, 2026

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Drury Inn & Suites St. Louis Arnold
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (62 reviews)
My grandson's birthday wish was to go camping with his mawmaw and being able to bring our old pup and share in memories was perfect

Reviewed on Apr 26, 2026

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Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Baymont by Wyndham Festus

Baymont by Wyndham Festus

3 out of 5
1200 W. Gannon Drive Festus MO
Book a stay at this family-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jorkerst Memorial Park and Sunset ...
6.8/10 (960 reviews)
Place could use a GOOD cleaning and paint job. No soap for shower or sink supplied. No extra towels provided. Cheap hotel for the area but still, a little quality would have been nice. Also, the free breakfast never happened.

Reviewed on Apr 26, 2026

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Baymont by Wyndham Festus
WoodSpring Suites St. Louis Arnold

WoodSpring Suites St. Louis Arnold

2.5 out of 5
888 Arnold Commons Dr. Arnold MO
Book a stay at this business-friendly hotel in Arnold. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in our ...
6.2/10 (481 reviews)
Overall room was good, bed was less than desirable.

Reviewed on Apr 15, 2026

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WoodSpring Suites St. Louis Arnold
See all 185 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.