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Featured Upstate South Carolina Family Hotels
Embassy Suites by Hilton Greenville Downtown Riverplace
250 Riverplace, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and 2 restaurants. Our guests praise the breakfast and the bar ...
Best Western Greenville Airport Inn
5009 Pelham Road, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Embassy Suites Greenville Golf Resort & Conference Center
670 Verdae Blvd, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3.5-star golf resort in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
Country Inn & Suites by Radisson, Anderson, SC
116 Interstate Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Hyatt Place Greenville/Haywood
40 W Orchard Park Dr, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Comfort Inn Greenville - Haywood Mall
246 Congaree Road, Greenville, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Comfort Suites Anderson-Clemson
118 Interstate Blvd, Anderson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Comfort Inn & Suites Greer - Greenville
1315 W Wade Hampton Blvd, Greer, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Greer. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Homewood Suites by Hilton Greenville
102 Carolina Point Pkwy, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this 3-star hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Haywood Mall and Bon Secours Wellness Arena are ...
Hampton Inn & Suites Greenville/Spartanburg I-85, SC
108 Spartangreen Blvd, Duncan, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Duncan. Enjoy free breakfast, free WiFi, and free parking. Popular attractions BMW Performance Center and Carolina ...
Inn @ Clemson
1303 Tiger Blvd, Clemson, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Hampton Inn Greenville/I-385 Haywood Mall
255 Congaree Road, Greenville, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Upstate South Carolina
Best Western Greenville Airport Inn
5009 Pelham Road, Greenville, SC
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.6/10 Good! (1,000 reviews)
Cant beat the value
"Pool was under reno while we were there. Not a huge deal but would have liked a heads up. Checkin was easy and the lady was very friendly. We used express check out. The room was clean and in good condition. Other than airport (planes) and a few sirens (firehouse near by) ot was pretty peaceful. ..."
Reviewed on May 27, 2025
Quality Inn & Suites Greenville - Haywood Mall
50 Orchard Park Drive, Greenville, SC
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. Popular attractions Haywood ...
7.4/10 Good! (1,003 reviews)
"Great place"
Reviewed on May 25, 2025
Country Inn & Suites by Radisson, Anderson, SC
116 Interstate Blvd, Anderson, SC
Book a stay at this business-friendly hotel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,000 reviews)
"I have stayed at this hotel before and have never had any problems with it or the staff. Very nice, clean, and great vibes from everyone."
Reviewed on May 27, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Upstate South Carolina
Aloft Greenville Downtown
5 North Laurens Street, Greenville, SC
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff ...
Best Western Plus Spartanburg
125 Sloane Garden Rd, Spartanburg, SC
Book a stay at this business-friendly hotel in Spartanburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn by Wyndham Anderson
1007 George Smith Mill Rd, Anderson, SC
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
More Hotel Options
- Hotels with Free Parking in Upstate South Carolina
- Hotels with a Pool in Upstate South Carolina
- Pet-friendly Hotels in Upstate South Carolina
- Historic Hotels in Upstate South Carolina
- Hotel Wedding Venues in Upstate South Carolina
- Romantic Hotels in Upstate South Carolina
- Apartment Hotel in Upstate South Carolina
- Luxury Hotels in Upstate South Carolina
- Hotels with Hot Tubs in Upstate South Carolina
- Resorts & Hotels with Spas in Upstate South Carolina
Upstate South Carolina Neighborhoods
- Greenville Downtown Hotels (8.63 mi)
- Nicholtown Hotels (7.29 mi)
- West End Hotels (8.94 mi)
- Overbrook Historic District Hotels (8.1 mi)
- Hampton-Pinckney Historic District Hotels (9.35 mi)
- Pettigru Street Historic District Hotels (8.31 mi)
- Colonel Elias Earle Historic District Hotels (9.34 mi)
- Downtown Hotels (38.83 mi)
- Woodside Cotton Mill Village Historic District Hotels (10.12 mi)
Top Points of Interests in Upstate South Carolina
- Hotels near Clemson University
- Hotels near Lake Jocassee
- Hotels near Falls Park on the Reedy
- Hotels near BMW Performance Center
- Hotels near Bon Secours Wellness Arena
- Hotels near Greenville Convention Center
- Hotels near Haywood Mall
- Hotels near Prisma Health Greenville Memorial Hospital
- Hotels near The Peace Center
- Hotels near Fred W. Symmes Chapel
- Hotels near Fluor Field at the West End
- Hotels near Table Rock State Park
- Hotels near Devils Fork State Park
- Hotels near Memorial Stadium
- Hotels near Wofford College
- Hotels near Bob Jones University
- Hotels near University of South Carolina Upstate
- Hotels near Anderson University
- Hotels near Tyger River Park
- Hotels near WestGate Mall
Cities near Upstate South Carolina
- Greenville Hotels (8.73 mi)
- Highlands Hotels (55.49 mi)
- Lake Lure Hotels (45.56 mi)
- Hendersonville Hotels (39.13 mi)
- Rock Hill Hotels (71.73 mi)
- Brevard Hotels (40.98 mi)
- Spartanburg Hotels (23.13 mi)
- Franklin Hotels (68.54 mi)
- Anderson Hotels (28.12 mi)
- North Carolina Mountains Hotels (64.32 mi)
- Clemson Hotels (32.31 mi)
- Seneca Hotels (38.76 mi)
- Black Mountain Hotels (58.45 mi)
- Cashiers Hotels (52.06 mi)
- Blue Ridge Mountains Hotels (68.54 mi)
- Gastonia Hotels (70.54 mi)
- Clayton Hotels (64.05 mi)
- Greer Hotels (11.86 mi)
- Sapphire Hotels (47.08 mi)
- Simpsonville Hotels (2.78 mi)
Car Rentals Near Upstate South Carolina
- Car rentals in Greenville
- Car rentals in Highlands
- Car rentals in Lake Lure
- Car rentals in Hendersonville
- Car rentals in Rock Hill
- Car rentals in Brevard
- Car rentals in Spartanburg
- Car rentals in Franklin
- Car rentals in Anderson
- Car rentals in North Carolina Mountains
- Car rentals in Clemson
- Car rentals in Seneca
- Car rentals in Black Mountain
- Car rentals in Cashiers
- Car rentals in Blue Ridge Mountains
- Car rentals in Gastonia
Top Family Hotel Destinations
- Las Vegas Family Hotels
- Arcade Family Hotels
- Branson Family Hotels
- Biloxi Family Hotels
- Ocean City Family Hotels
- Orlando Family Hotels
- Buffalo Family Hotels
- Reno Family Hotels
- Colorado Springs Family Hotels
- Phoenix Family Hotels
- Niagara Falls Family Hotels
- New York Family Hotels
- Whistler Family Hotels
- Houston Family Hotels
- Fort Walton Beach Family Hotels
- Pensacola Beach Family Hotels
- Tampa Family Hotels
- Myrtle Beach Family Hotels
- Miami Beach Family Hotels
- Birmingham Family Hotels
Top Booked Hotels in Upstate South Carolina
- Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
- Hilton Greenville
- Hyatt Place Greenville/Haywood
- La Quinta Inn & Suites by Wyndham Greenville Haywood
- Days Inn by Wyndham Anderson
- Best Western Plus Greenville I-385 Inn & Suites
- Comfort Inn Greenville - Haywood Mall
- Hyatt Regency Greenville
- Courtyard by Marriott Greenville Haywood Mall
- Hyatt Place Greenville/Downtown
- Quality Inn & Suites Greenville - Haywood Mall
- Embassy Suites Greenville Golf Resort & Conference Center
- Best Western Greenville Airport Inn