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Hotels in Upstate South Carolina

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Choose from 2759 Upstate South Carolina Hotel Deals

Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8/10 Very Good! (1,000 reviews)
"I like that fact you can’t get anywhere in the building unless you have a key card"

Reviewed on Jul 5, 2025

Hilton Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
3.5 out of 5
851 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the room ...
8.4/10 Very Good! (1,001 reviews)
Our first Greenville, SC experience
"My family and I enjoyed our stay. The hotel location was perfect for our needs. Easy access to the highway and getting to downtown Greenvillewas a plus. The hotel itself was comfortable. No noise complaints or smoking in the hotel and the environment was calm and friendly. I found the rear parking ..."

Reviewed on Jul 1, 2025

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
La Quinta Inn & Suites by Wyndham Greenville Haywood
La Quinta Inn & Suites by Wyndham Greenville Haywood
3 out of 5
65 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 3-star hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (1,002 reviews)
"Had a great time with great customer service."

Reviewed on Jul 9, 2025

La Quinta Inn & Suites by Wyndham Greenville Haywood
Woodspring Suites Greenville Airport
Woodspring Suites Greenville Airport
2.5 out of 5
205 Entertainment Blvd, Greenville, SC
  • 2 hours drive from Clemson University
Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Haywood Mall and BMW Performance Center are located nearby.
8.4/10 Very Good! (94 reviews)
"The kitchen"

Reviewed on Jul 8, 2025

Woodspring Suites Greenville Airport
Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood Mall
2.5 out of 5
246 Congaree Road, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,002 reviews)
"I wish it was more handicap accessible but overall great property to stay at"

Reviewed on Jul 7, 2025

Comfort Inn Greenville - Haywood Mall
Days Inn by Wyndham Anderson
Days Inn by Wyndham Anderson
2 out of 5
1007 George Smith Mill Rd, Anderson, SC
  • 28 min drive from Clemson University
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,011 reviews)
"Kind, cordial, professional, young man as I checked in.Spacious, clean, comfortable room. Quiet area! Housekeeper was friendly, greeted me every morning although I didn’t need services."

Reviewed on Jul 9, 2025

Days Inn by Wyndham Anderson
Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.6/10 Excellent! (1,004 reviews)
"We chose Hyatt Regency because of its proximity to Bon Secours arena. What we also enjoyed was the food, the cleanliness of our room, the comfort of the bed, quiet, and a very friendly and helpful staff."

Reviewed on Jul 10, 2025

Hyatt Regency Greenville
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites
2.5 out of 5
831 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,337 reviews)
Pleasantly surprised!
"Hotel was perfectly located for our needs with lots of options for dinner - the front desk staff was so gracious and recommended a few places. Clean hotel with courteous staff. Breakfast could use some more milk options (Almond, Oat) but otherwise pretty standard. Room was very clean and the bed ..."

Reviewed on Jul 8, 2025

Best Western Plus Greenville I-385 Inn & Suites
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this 4-star spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (355 reviews)
"We had a wonderful 3 night stay in Greenville, and the location of the Grand Bohemian made it a perfect location for walking and biking on the path and enjoying the lover river flowing through the middle of the city. We loved every moment of our stay, and we will definitely be back soon!"

Reviewed on Jul 10, 2025

Grand Bohemian Lodge Greenville, Autograph Collection
Wingate by Wyndham - Greenville-Airport
Wingate by Wyndham - Greenville-Airport
2.5 out of 5
33 Beacon Dr, Greenville, SC
  • 2 hours drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,003 reviews)
"Great housekeeping room always clean.. breakfast needs upgrading,, eggs bland and muffins taste like eating air.. no flavor.."

Reviewed on Jul 4, 2025

Wingate by Wyndham - Greenville-Airport
Hyatt Place Greenville/Haywood
Hyatt Place Greenville/Haywood
3 out of 5
40 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (1,009 reviews)
"This was my second time staying at this hotel. Very nice rooms comfortable beds and very friendly staff."

Reviewed on Jul 10, 2025

Hyatt Place Greenville/Haywood
Quality Inn & Suites Greenville - Haywood Mall
Quality Inn & Suites Greenville - Haywood Mall
2.5 out of 5
50 Orchard Park Drive, Greenville, SC
  • 1 hour drive from Clemson University
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. Popular attractions Haywood ...
7.4/10 Good! (1,000 reviews)
Good experience
"Well run establishment"

Reviewed on Jul 1, 2025

Quality Inn & Suites Greenville - Haywood Mall
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Upstate South Carolina

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,759 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $65. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as $65.

How many hotels are there in Upstate South Carolina?

With over 2,759 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $65.

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.