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Hotels in Upstate South Carolina

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Last Minute Hot Rate® Hotel Deals in Upstate South Carolina

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Choose from 2097 Upstate South Carolina Hotel Deals

Urban Boutique Hotel, BW Signature Collection
Urban Boutique Hotel, BW Signature Collection
2.5 out of 5
536 Wade Hampton Blvd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $60 per night from Jun 29 to Jun 30
$60
per night
Jun 29 - Jun 30
Stay at this motel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (462 reviews)
"The room was clean. The bedspread looked a bit worn, but everything else was good. The offered a variety of breakfast good. The biscuits were hard and almost inedible."

Reviewed on Jun 1, 2023

Urban Boutique Hotel, BW Signature Collection
Best Western Greenville Airport Inn
Best Western Greenville Airport Inn
2.5 out of 5
5009 Pelham Road, Greenville, SC
  • 2 hours drive from Clemson University
The price is $76 per night from Jun 11 to Jun 12
$76
per night
Jun 11 - Jun 12
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
7.8/10 Good! (1,000 reviews)
"Although this property is older and does show it's age in some areas, that doesn't mean that much to us if it is clean and quiet, which our room was. The breakfast was a step above our previous night's stay, so we were pleased. The front desk lady was training a new employee and was very patient ..."

Reviewed on May 17, 2023

Best Western Greenville Airport Inn
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites
2.5 out of 5
831 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $84 per night from Jul 3 to Jul 4
$84
per night
Jul 3 - Jul 4
Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,004 reviews)
Friendly staff, very clean
"Very comfortable stay. Hotel and room was very clean and comfortable. Staff was very friendly and helpful. I would recommend and stay there again."

Reviewed on Jun 9, 2023

Best Western Plus Greenville I-385 Inn & Suites
La Quinta Inn & Suites by Wyndham Greenville Haywood
La Quinta Inn & Suites by Wyndham Greenville Haywood
2.5 out of 5
65 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
The price is $87 per night from Jun 15 to Jun 16
$87
per night
Jun 15 - Jun 16
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions ...
8.2/10 Very Good! (1,004 reviews)
"It conveniently located near downtown Greenville and Furman University."

Reviewed on Jun 6, 2023

La Quinta Inn & Suites by Wyndham Greenville Haywood
Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
The price is $110 per night from Jul 2 to Jul 3
$110
per night
Jul 2 - Jul 3
Stay at this 3.5-star business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and breakfast. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,004 reviews)
Family visit
"The Hilton Greenville never disappoints"

Reviewed on Jun 8, 2023

Hilton Greenville
Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood Mall
2.5 out of 5
246 Congaree Road, Greenville, SC
  • 1 hour drive from Clemson University
The price is $86 per night from Jun 28 to Jun 29
$86
per night
Jun 28 - Jun 29
Stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,000 reviews)
"You can’t beat this Comfort Inn for the price. The rooms are clean, the beds are comfy and the staff is helpful and friendly."

Reviewed on May 28, 2023

Comfort Inn Greenville - Haywood Mall
Days Inn by Wyndham Simpsonville
Days Inn by Wyndham Simpsonville
2 out of 5
45 Ray E Talley Ct, Simpsonville, SC
  • 2 hours drive from Clemson University
The price is $83 per night from Jul 9 to Jul 10
$83
per night
Jul 9 - Jul 10
Stay at this business-friendly motel in Simpsonville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the comfy rooms ...
7/10 Good! (265 reviews)
"Very convenient."

Reviewed on May 29, 2023

Days Inn by Wyndham Simpsonville
Hyatt Place Greenville/Downtown
Hyatt Place Greenville/Downtown
3 out of 5
128 East Broad Street, Greenville, SC
  • 1 hour drive from Clemson University
The price is $148 per night from Jul 2 to Jul 3
$148
per night
Jul 2 - Jul 3
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
8.8/10 Excellent! (1,041 reviews)
"Great option for downtown activity!"

Reviewed on Jun 5, 2023

Hyatt Place Greenville/Downtown
Comfort Suites Greenville Airport
Comfort Suites Greenville Airport
2.5 out of 5
1371 Garlington Road, Greenville, SC
  • 2 hours drive from Clemson University
The price is $107 per night from Jun 18 to Jun 19
$107
per night
Jun 18 - Jun 19
Stay at this golf hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the clean rooms in our reviews. ...
9.4/10 Exceptional! (514 reviews)
"We didn’t arrive until after 9:30pm. The gentleman that checked us in was awesome! He was so kind, had a great sense of humor, and remembered our name after check-in. I wish we would’ve gotten his name but he made us feel so welcome!"

Reviewed on Jun 5, 2023

Comfort Suites Greenville Airport
Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference Center
2.5 out of 5
1310 Tiger Blvd, Clemson, SC
  • 22 min walk from Clemson University
The price is $84 per night from Jun 17 to Jun 18
$84
per night
Jun 17 - Jun 18
Stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
8.2/10 Very Good! (607 reviews)
"Older Property Beautifully Updated. Last Minute Booking Visiting Family Camping Nearby. The Hotel Wasn't Able To Honor Our Amended Request For A Ground Level Or Accessible Room, But Clemson Was Hosting A NCAA Baseball Game That Night. Still, A Very Enjoyable Stay."

Reviewed on Jun 5, 2023

Best Western Plus Clemson Hotel & Conference Center
Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University Area
2.5 out of 5
1305 Tiger Blvd, Clemson, SC
  • 23 min walk from Clemson University
The price is $89 per night from Jun 23 to Jun 24
$89
per night
Jun 23 - Jun 24
Stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.2/10 Very Good! (855 reviews)
"Room didn't smell fresh"

Reviewed on Jun 6, 2023

Comfort Inn & Suites Clemson - University Area
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
  • 1 hour drive from Clemson University
The price is $212 per night from Jul 9 to Jul 10
$212
per night
Jul 9 - Jul 10
Stay at this 4-star spa hotel in Greenville. Enjoy free WiFi, a full-service spa, and breakfast. Popular attractions Falls Park on the Reedy and The Peace Center ...
9/10 Wonderful! (56 reviews)
"Beautiful and glamorous place!"

Reviewed on May 25, 2023

Grand Bohemian Lodge Greenville, Autograph Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Upstate South Carolina

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Upstate South Carolina hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,097 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as $60.

How many hotels are there in Upstate South Carolina?

With over 2,097 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Upstate South Carolina now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Upstate South Carolina right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.