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Hotels in Southwest Illinois

Choose from 675 Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon
Drury Plaza Hotel Mt. Vernon
3 out of 5
145 North 44th Street , Mount Vernon, IL
  • 2 hours drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,373 reviews)
"Very happy with our 1 night stay with our littles"

Reviewed on Jul 5, 2025

Drury Plaza Hotel Mt. Vernon
Best Western Plus Pontoon Beach
Best Western Plus Pontoon Beach
3 out of 5
4 Regency Pkwy, Granite City, IL
  • 3 hours drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (684 reviews)
"Pool was great n breakfast good. Only thing that was bad was that our fitted sheet had several tears n holes in it. Room was clean."

Reviewed on Jul 3, 2025

Best Western Plus Pontoon Beach
Super 8 by Wyndham O'Fallon
Super 8 by Wyndham O'Fallon
2 out of 5
1100 Eastgate Dr, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,004 reviews)
"A little out of the way, but good value"

Reviewed on Jul 3, 2025

Super 8 by Wyndham O'Fallon
Drury Inn & Suites Marion
Drury Inn & Suites Marion
3 out of 5
2706 W DeYoung St, Marion, IL
  • 42 min drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,000 reviews)
"It was nice to feel safe! the property was well maintained. With the offer of up to 3 drinks per guest it allowed us a place to sit and chat for a couple hours instead of trying to sit on the beds in the rooms and chat. I meet 2 different family members there for just a night, we appreciate the facility ..."

Reviewed on Jun 29, 2025

Drury Inn & Suites Marion
Quality Inn & Suites near St. Louis and I-255
Quality Inn & Suites near St. Louis and I-255
2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in East St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.4/10 Good! (999 reviews)
"Gvg"

Reviewed on Jun 30, 2025

Quality Inn & Suites near St. Louis and I-255
Drury Inn & Suites St. Louis Fairview Heights
Drury Inn & Suites St. Louis Fairview Heights
3 out of 5
12 Ludwig Dr, Fairview Heights, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,013 reviews)
"My stay was very nice"

Reviewed on Jul 8, 2025

Drury Inn & Suites St. Louis Fairview Heights
Days Inn & Suites by Wyndham Caseyville
Days Inn & Suites by Wyndham Caseyville
2.5 out of 5
2423 Old Country Inn Drive, Caseyville, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Caseyville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pleasant Ridge Park and Cahokia ...
3.8/10 (248 reviews)
"Maybe they need to repair the ice machine and bring back the snacks machines with card options. Maybe a convenient store inside. Repair the coin washer plus other things. But I still think it’s the best option to do the main things you do on a room: rest and be relaxed."

Reviewed on Jun 30, 2025

Days Inn & Suites by Wyndham Caseyville
Red Lion Inn & Suites Pontoon Beach
Red Lion Inn & Suites Pontoon Beach
2.5 out of 5
1240 E Chain Of Rocks Rd, Granite City, IL
  • 3 hours drive from Southern Illinois University
Stay at this hotel in Granite City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
7.8/10 Good! (424 reviews)
"The room was very nice and clean. Microwave was not plugged in so could not use it and frig had rust on inside. Staff was very pleasant."

Reviewed on Jul 8, 2025

Red Lion Inn & Suites Pontoon Beach
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
3 out of 5
136 Regency Park, O'Fallon, IL
  • 3 hours drive from Southern Illinois University
Stay at this 3-star business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
6.2/10 (1,005 reviews)
Honest review
"Room was clean and everything else. However the smell when you go through those doors are not the best, stink really bad."

Reviewed on Jun 30, 2025

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
Comfort Inn Collinsville near St. Louis
Comfort Inn Collinsville near St. Louis
2.5 out of 5
8 Commerce Dr, Collinsville, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (784 reviews)
"Clean. Comfortable bed. Good bfast."

Reviewed on Jul 3, 2025

Comfort Inn Collinsville near St. Louis
Baymont by Wyndham Marion
Baymont by Wyndham Marion
2.5 out of 5
2608 W Main St, Marion, IL
  • 43 min drive from Southern Illinois University
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,020 reviews)
"Very clean and spacious room. Pet allowed. Very quiet and affordable. The bed was very comfortable."

Reviewed on Jul 6, 2025

Baymont by Wyndham Marion
Days Inn by Wyndham Collinsville/St. Louis
Days Inn by Wyndham Collinsville/St. Louis
2.5 out of 5
12 Commerce Drive, I-55/70 and IL 157, Collinsville, IL
  • 3 hours drive from Southern Illinois University
Book a stay at this business-friendly hotel in Collinsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
"Very quiet and comfortable. Nice room and very nice staff from the front desk to room attendants."

Reviewed on Jul 7, 2025

Days Inn by Wyndham Collinsville/St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Southwest Illinois

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Southwest Illinois.

Choosing the right hotel in Illinois has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Southwest Illinois’s 675 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $60. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Southwest Illinois hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Southwest Illinois. No matter your reason for visiting Southwest Illinois, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Southwest Illinois hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Southwest Illinois for as low as $60.

How many hotels are there in Southwest Illinois?

With over 675 hotels in Southwest Illinois, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $60.

How to find cheap car rentals in Southwest Illinois?

Finding a cheap car rental deal in Southwest Illinois is as easy as scoring cheap hotels in Southwest Illinois. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.