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Featured Santee Family Hotels
Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
Hampton Inn Santee-I-95
9060 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Holiday Inn Santee by IHG
139 Bradford Blvd, Santee, SC
Fully refundable
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
Econo Lodge
9112 Old 6 Highway, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee Outlets are ...
Travelodge by Wyndham Santee
9117 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Super 8 by Wyndham Santee
9125 Old Highway 6, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
Baymont by Wyndham Santee
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Ramada by Wyndham Santee I-95
123 Mall Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Santee Cooper Country Club and Santee ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels with Pools in Santee
Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,000 reviews)
"Goof"
Reviewed on Jun 1, 2025
Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (995 reviews)
Convenient and Friendly Staff
"Conveniently located off I-95. The staff were all very friendly. The rooms were very spacious. The breakfast was great! The only downside was the beds need updated. They were very springy and uncomfortable. Overall good stay."
Reviewed on May 28, 2025
Baymont by Wyndham Santee
249 Britain Street, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,303 reviews)
"nice place to stay on are way too Kentucky . Nothing fancy but always clean."
Reviewed on Jun 1, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels With Connecting Rooms in Santee
Best Western Plus Santee Inn
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Comfort Inn & Suites Santee
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
Super 8 by Wyndham Santee
9125 Old Highway 6, Santee, SC
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee Outlets ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Hotels by Star Rating
Top Points of Interests in Santee
- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee Outlets
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Edisto Memorial Gardens
- Hotels near Wyboo Golf Club
- Hotels near St. George United Methodist Church
- Hotels near Foxboro Golf Club
- Hotels near St. George Country Club
- Hotels near Jennie J McMahan Library
- Hotels near Santee Indian Mound and Fort Watson Site
Cities near Santee
- Coastal South Carolina Hotels (39.54 mi)
- Sumter Hotels (30.87 mi)
- Orangeburg Hotels (21.85 mi)
- Manning Hotels (20.95 mi)
- Lake Marion Hotels (7.89 mi)
- St. George Hotels (21.56 mi)
- Summerton Hotels (11.01 mi)
- Southeastern United States Hotels (212.28 mi)
- The Carolinas Hotels (107.21 mi)
- Eutawville Hotels (9.84 mi)
- Cross Hotels (21.9 mi)
- Ridgeville Hotels (28.75 mi)
- Holly Hill Hotels (12.11 mi)
- Pineville Hotels (26.07 mi)
- Saint Matthews Hotels (21.24 mi)
- Vance Hotels (4.82 mi)
- Elloree Hotels (6.29 mi)
- Gadsden Hotels (29.81 mi)
- Harleyville Hotels (18.94 mi)
- Walterboro - St. George Hotels (40.85 mi)
Car Rentals Near Santee
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Top Family Hotel Destinations
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Top Booked Hotels in Santee
- Holiday Inn Santee by IHG
- Fairfield Inn & Suites by Marriott Santee
- Hampton Inn Santee-I-95
- Comfort Inn & Suites Santee
- Travelodge by Wyndham Santee
- Best Western Plus Santee Inn
- Red Roof Inn Santee
- Ramada by Wyndham Santee I-95
- Super 8 by Wyndham Santee
- Econo Lodge
- Days Inn by Wyndham St George
- SureStay Hotel by Best Western Manning