Search Cheap Flights to
Santee

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Santee Flights as Low as $261

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Aug 18 - Tue, Sep 1
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$261 Roundtrip, found 2 hours ago
$261
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Tue, Aug 18 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Tue, Sep 1, priced at $261 found 2 hours ago
United
Tue, Aug 18 - Tue, Sep 1
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$261 Roundtrip, found 2 hours ago
$261
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Aug 18 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Tue, Sep 1, priced at $261 found 2 hours ago
Delta
Tue, Aug 18 - Tue, Sep 1
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$261 Roundtrip, found 2 hours ago
$261
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Aug 18 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Tue, Sep 1, priced at $261 found 2 hours ago
Delta
Wed, Jul 22 - Wed, Jul 29
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$267 Roundtrip, found 2 hours ago
$267
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Jul 22 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Wed, Jul 29, priced at $267 found 2 hours ago
American Airlines
Wed, Jul 1 - Tue, Jul 21
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$267 Roundtrip, found 2 hours ago
$267
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Wed, Jul 1 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Tue, Jul 21, priced at $267 found 2 hours ago
American Airlines
Tue, Sep 15 - Tue, Sep 22
PVD
T.F. Green
CAE
Columbia Metropolitan
$275 Roundtrip, found 2 hours ago
$275
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Tue, Sep 15 from T.F. Green to Columbia Metropolitan, returning Tue, Sep 22, priced at $275 found 2 hours ago
Delta
Fri, Jul 24 - Wed, Jul 29
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$275 Roundtrip, found 20 hours ago
$275
Roundtrip
found 20 hours ago
Select Delta flight, departing Fri, Jul 24 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Wed, Jul 29, priced at $275 found 20 hours ago
Delta
Wed, Jul 15 - Sun, Jul 19
IAD
Washington Dulles Intl.
CAE
Columbia Metropolitan
$275 Roundtrip, found 2 hours ago
$275
Roundtrip
found 2 hours ago
Select Delta flight, departing Wed, Jul 15 from Washington Dulles Intl. to Columbia Metropolitan, returning Sun, Jul 19, priced at $275 found 2 hours ago
Delta
Wed, Aug 5 - Tue, Aug 18
DCA
Ronald Reagan Washington National
CAE
Columbia Metropolitan
$275 Roundtrip, found 6 days ago
$275
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Aug 5 from Ronald Reagan Washington National to Columbia Metropolitan, returning Tue, Aug 18, priced at $275 found 6 days ago
Delta
Thu, Jul 23 - Wed, Jul 29
CMH
John Glenn Columbus Intl.
CAE
Columbia Metropolitan
$281 Roundtrip, found 20 hours ago
$281
Roundtrip
found 20 hours ago
Select Delta flight, departing Thu, Jul 23 from John Glenn Columbus Intl. to Columbia Metropolitan, returning Wed, Jul 29, priced at $281 found 20 hours ago
Delta
Wed, Jul 29 - Tue, Aug 18
BWI
Baltimore Washington Intl. Thurgood Marshall
CAE
Columbia Metropolitan
$297 Roundtrip, found 3 days ago
$297
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Jul 29 from Baltimore Washington Intl. Thurgood Marshall to Columbia Metropolitan, returning Tue, Aug 18, priced at $297 found 3 days ago
American Airlines
Fri, Jul 31 - Sun, Aug 16
DCA
Ronald Reagan Washington National
CAE
Columbia Metropolitan
$301 Roundtrip, found 5 days ago
$301
Roundtrip
found 5 days ago
Select American Airlines flight, departing Fri, Jul 31 from Ronald Reagan Washington National to Columbia Metropolitan, returning Sun, Aug 16, priced at $301 found 5 days ago
Delta
Tue, Jul 21 - Thu, Jul 23
FLL
Fort Lauderdale - Hollywood Intl.
CAE
Columbia Metropolitan
$324 Roundtrip, found 17 hours ago
$324
Roundtrip
found 17 hours ago
Select Delta flight, departing Tue, Jul 21 from Fort Lauderdale - Hollywood Intl. to Columbia Metropolitan, returning Thu, Jul 23, priced at $324 found 17 hours ago
American Airlines
Sat, Jul 11 - Tue, Jul 14
JFK
John F. Kennedy Intl.
CAE
Columbia Metropolitan
$336 Roundtrip, found 1 day ago
$336
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 11 from John F. Kennedy Intl. to Columbia Metropolitan, returning Tue, Jul 14, priced at $336 found 1 day ago
American Airlines
Sat, Jul 4 - Sat, Jul 18
RSW
Southwest Florida Intl.
CAE
Columbia Metropolitan
$386 Roundtrip, found 2 hours ago
$386
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, Jul 4 from Southwest Florida Intl. to Columbia Metropolitan, returning Sat, Jul 18, priced at $386 found 2 hours ago
American Airlines
Sat, Jul 11 - Sat, Jul 25
MIA
Miami Intl.
CAE
Columbia Metropolitan
$406 Roundtrip, found 2 hours ago
$406
Roundtrip
found 2 hours ago
Select American Airlines flight, departing Sat, Jul 11 from Miami Intl. to Columbia Metropolitan, returning Sat, Jul 25, priced at $406 found 2 hours ago

Cheap Flights to Santee

Fall in love at first flight with your vacation to Santee by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santee on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santee, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santee

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santee with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CAE airport.

What is the cheapest month to fly to Santee?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santee are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santee?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santee.

What airport is best to fly into Santee?

When you’re planning your trip to Santee, convenience is the name of the game. Luckily, Santee Charleston Intl. Airport is nearby so you can deplane and get going on checking off everything on your Santee must-do list.

How much are flights to Santee?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santee on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $261, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santee?

The trick to saving a stack of cash on your flight to Santee? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $261 right now, why wait?

Santee Flight Information
Destination airport
Columbia Metropolitan
Destination airport IATA code
CAE
Roundtrip price
$260

Last Minute Hotel Deals in Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,470 reviews)
"This is a beautiful property. Too bad is was unkept. The grass seriously needed mowing. But the staff was pleasant, the amenities were great, nice pool, clean and spacious room. It’s sad this beautiful property has not been kept up. This would be an awesome hotel if it had. But if you don’t mind ..."

Reviewed on Jun 18, 2026

Get rates
Baymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

3 out of 5
9074 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (1,002 reviews)
"Upon arrival I was greeted at the front desk by Brandon. He made check in comfortable and easy. The hotel was immaculately clean and the staff was so friendly and helpful. The room was clean and comfortable. The complimentary breakfast was outstanding! The lady working it was on top of everything, ..."

Reviewed on Jun 17, 2026

Get rates
Fairfield Inn & Suites by Marriott Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.2/10 Wonderful! (857 reviews)
"Great hotel. Very clean and helpful staff."

Reviewed on Jun 18, 2026

Get rates
Tru By Hilton Santee
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98 Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
"Room was clean and parking was great. Didn’t use much of the amenities but the pool was very inviting!"

Reviewed on Jun 15, 2026

Get rates
Best Western Plus Santee Inn
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (1,000 reviews)
"Great breakfast and wonderful staff. Try the Thai restaurant next door. Wow"

Reviewed on Jun 15, 2026

Get rates
Hampton Inn Santee-I-95
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,012 reviews)
"Clean rooms that were connecting which we requested. Friendly staff. Good breakfast. Met all our needs while traveling with six children."

Reviewed on Jun 11, 2026

Get rates
Comfort Inn & Suites Santee
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

2.5 out of 5
8929 Old Number Six Highway Santee SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6/10 (543 reviews)
"We booked a king room on-line and prepaid. There was no mention that the room was on the second floor with no elevators. My husband is in a wheelchair and can't do steps. When we arrived, we were told we needed to pay an additional $20 to "upgrade" to a first floor unit which had 2 queen beds. This ..."

Reviewed on Jun 18, 2026

Get rates
Quality Inn & Suites Santee I-95
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy Santee SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
7.2/10 Good! (740 reviews)
"Clean rooms and bathrooms except for parking someone was parking in my space"

Reviewed on Jun 17, 2026

Get rates
Travelodge by Wyndham Santee
See all 305 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.