Search for Cheap Deals on
Kid-Friendly Hotels in Santee

Check Last Minute Santee Hotel Deals

Tonight Oct 17 - Oct 18This weekend Oct 17 - Oct 19

You choose what matters — star rating, location, amenities.

We pick the perfect hotel, packed with all your must-haves.

Your hotel is revealed right after booking!

Featured Santee Family Hotels

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
Comfort Inn & Suites Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Hampton Inn Santee-I-95
Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Plus Santee Inn
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

3 out of 5
139 Bradford Blvd, Santee, SC
Fully refundable
Stay at this 3-star golf hotel in Santee. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in ...
Holiday Inn Santee by IHG
Econo Lodge

Econo Lodge

2 out of 5
9112 Old 6 Highway, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Santee Cooper Country Club and Santee National Golf ...
Econo Lodge
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

2 out of 5
9117 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Travelodge by Wyndham Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
Super 8 by Wyndham Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Baymont by Wyndham Santee
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

2 out of 5
123 Mall Street, Santee, SC
Fully refundableReserve now, pay when you stay
Book a stay at this golf hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
Ramada by Wyndham Santee I-95
See all 291 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels with Pools in Santee

Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,003 reviews)
"The staff was very friendly and welcoming. The enviroment was very calm and peaceful."

Reviewed on Oct 10, 2025

Best Western Plus Santee Inn
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
8/10 Very Good! (1,000 reviews)
Nice mid trip stop
"Lobby and dining area were very clean. Our room was a little dated but clean and well kept. The staff were also all very friendly and helpful.We only stayed 1 night as it was a stopping point for a longer trip."

Reviewed on Sep 5, 2025

Comfort Inn & Suites Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,358 reviews)
"Overall trip was good, large room comfortable, older hotel by relatively nice. Saw a roach right before checking out, overall okay."

Reviewed on Oct 12, 2025

Baymont by Wyndham Santee
See all 291 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels With Connecting Rooms in Santee

Best Western Plus Santee Inn

Best Western Plus Santee Inn

2.5 out of 5
I 95 Exit 98, Santee, SC
Book a stay at this business-friendly hotel in Santee. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful ...
Best Western Plus Santee Inn
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

2.5 out of 5
221 Britain St, Santee, SC
Stay at this hotel in Santee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Santee ...
Comfort Inn & Suites Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

2 out of 5
9125 Old Highway 6, Santee, SC
Book a stay at this golf motel in Santee. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Santee Cooper Country Club and Santee National ...
Super 8 by Wyndham Santee
See all 291 properties in Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.