Search for Cheap Deals on
Hotels in Mayfield Heights

Choose from 1740 Mayfield Heights Hotel Deals

Comfort Inn Mayfield Heights Cleveland East

Comfort Inn Mayfield Heights Cleveland East

2.5 out of 5
1421 Golden Gate Blvd Mayfield Heights OH
  • 16 min walk from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Mayfield Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,004 reviews)
Great staff, room was clean and beds comfortable

Reviewed on Apr 6, 2026

Comfort Inn Mayfield Heights Cleveland East
Staybridge Suites Cleveland Mayfield Heights Beachwood by IHG

Staybridge Suites Cleveland Mayfield Heights Beachwood by IHG

3 out of 5
6103 Landerhaven Drive Mayfield Heights OH
  • 4 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Mayfield Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
8.2/10 Very Good! (1,004 reviews)
Everything was great

Reviewed on Apr 1, 2026

Staybridge Suites Cleveland Mayfield Heights Beachwood by IHG
Hotel Indigo Cleveland Downtown by IHG

Hotel Indigo Cleveland Downtown by IHG

3.5 out of 5
651 Huron Rd E Cleveland OH
  • 33 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
8.4/10 Very Good! (1,620 reviews)
The rooms were comfortable and clean. The location was convenient, and the staff was helpful. Very nice for option for a quick trip and overnight stay.

Reviewed on Apr 6, 2026

Hotel Indigo Cleveland Downtown by IHG
The Westin Cleveland Downtown

The Westin Cleveland Downtown

4 out of 5
777 Saint Clair Ave Ne Cleveland OH
  • 34 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (2,118 reviews)
Great staff very friendly. Comfortable rooms.

Reviewed on Apr 6, 2026

The Westin Cleveland Downtown
Hotel Cleveland, Autograph Collection

Hotel Cleveland, Autograph Collection

4 out of 5
24 Public Sq Cleveland OH
  • 34 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this historic hotel in Cleveland. Enjoy breakfast (surcharge), a fitness center, and valet parking (surcharge). Our guests praise the helpful ...
9/10 Wonderful! (304 reviews)
Great location!

Reviewed on Apr 6, 2026

Hotel Cleveland, Autograph Collection
Holiday Inn Cleveland Clinic by IHG

Holiday Inn Cleveland Clinic by IHG

3 out of 5
8650 Euclid Ave Cleveland OH
  • 25 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
8.8/10 Excellent! (1,314 reviews)
It’s ok

Reviewed on Apr 5, 2026

Holiday Inn Cleveland Clinic by IHG
Kimpton Schofield Hotel by IHG

Kimpton Schofield Hotel by IHG

4.5 out of 5
2000 East Ninth Street Cleveland OH
  • 33 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this luxury hotel in Cleveland. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the restaurant and ...
8.8/10 Excellent! (1,012 reviews)
I love the front desk staff & the staff at Bett’s. They make every stay special.

Reviewed on Apr 6, 2026

Kimpton Schofield Hotel by IHG
Hyatt Regency Cleveland At The Arcade

Hyatt Regency Cleveland At The Arcade

4 out of 5
420 Superior Ave E Cleveland OH
  • 34 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Cleveland. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,146 reviews)
We were pleasantly surprised with his hotel. It was quite nice. Probably the only negative thing was there was some rumbling from inside the building. We couldn’t figure out if it was a subway or if it was the building itself. It periodically would shake the walls. Very historic building. We would ...

Reviewed on Apr 5, 2026

Hyatt Regency Cleveland At The Arcade
Hilton Cleveland Downtown

Hilton Cleveland Downtown

4 out of 5
100 Lakeside Ave East Cleveland OH
  • 34 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Cleveland. Enjoy 2 bars/lounges, breakfast (surcharge), and room service. Our guests praise the helpful staff ...
9.2/10 Wonderful! (1,365 reviews)
Excellent!

Reviewed on Apr 6, 2026

Hilton Cleveland Downtown
Drury Plaza Hotel Cleveland Downtown

Drury Plaza Hotel Cleveland Downtown

3 out of 5
1380 East 6th Street Cleveland OH
  • 34 min drive from Cleveland Clinic - Hillcrest Hospital
Stay at this hotel in Cleveland. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (2,712 reviews)
Out of all the Durry’s we have stayed in, this is our least favorite. There was a scramble to find our room when we checked in which prolonged our wait to get to our room. Parking is also a fiasco having to wait on somebody to bring your car to you at all times, and likewise, I saw them pulling quickly ...

Reviewed on Apr 6, 2026

Drury Plaza Hotel Cleveland Downtown
Spark by Hilton Cleveland Beachwood

Spark by Hilton Cleveland Beachwood

3 out of 5
26300 Chagrin Blvd Beachwood OH
  • 12 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Beachwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (299 reviews)
Temp was ok, no pets for us

Reviewed on Apr 6, 2026

Spark by Hilton Cleveland Beachwood
Wyndham Independence

Wyndham Independence

4 out of 5
6200 Quarry Lane Independence OH
  • 36 min drive from Cleveland Clinic - Hillcrest Hospital
Book a stay at this business-friendly hotel in Independence. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Cleveland Metroparks ...
6.4/10 (1,080 reviews)
Staff was great. Bed and bathroom clean. But the carpet and furniture all have stains and feel kind of grimy , couch in the room even had shredded armrests from a cat clawing it. The pool and hot tub were open but a large group of screaming kids had taken ove the pool and the hot tub had no "bubble" ...

Reviewed on Apr 6, 2026

Wyndham Independence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Mayfield Heights

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Mayfield Heights hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Mayfield Heights.

Choosing the right hotel in Ohio has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Mayfield Heights’s 1,740 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $68. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Mayfield Heights hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Mayfield Heights. No matter your reason for visiting Mayfield Heights, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Mayfield Heights hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Mayfield Heights for as low as $68.

How many hotels are there in Mayfield Heights?

With over 1,740 hotels in Mayfield Heights, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $68.

How to find cheap car rentals in Mayfield Heights?

Finding a cheap car rental deal in Mayfield Heights is as easy as scoring cheap hotels in Mayfield Heights. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.