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Hollywood Casino & Hotel St. Louis
"I booked a hotel room to stay the night at after seeing Hilary Duff's concert on 7/22/2026 (highly recommend seeing her live!), & overall it was a 8 out of 10. The hotel was very nice both inside & outside, the staff was courteous, kind, & helpful, & the shuttle services provided to & from the concert ..."
Reviewed on Jul 25, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
"Rooms were clean, had to ask for a couple little things. Did not like the barking dogs."
Reviewed on Jul 26, 2026
Ameristar Casino Resort and Spa
The Wildwood Hotel
"The staff was wonderful"
Reviewed on Jul 25, 2026
Hilton St. Louis Frontenac
"The staff was very friendly and welcoming"
Reviewed on Jul 24, 2026
La Quinta Inn & Suites by Wyndham St. Louis Westport
Wingate by Wyndham St. Louis/Fenton Route 66
"The hotel pictures looked good but were very deceiving! There was a bad smell that I had to spray our room with perfume a few times a day just to cover it. The bathroom was not very clean and the whole hotel looked like it was from the 1980’s! Not a good experience at all!!! Would not suggest it ..."
Reviewed on Jul 25, 2026
Drury Plaza Hotel St. Louis Chesterfield
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Reviewed on Jul 25, 2026
Sonesta ES Suites St. Louis - Chesterfield
"Overall, we had a good stay here. My only complaint is that there was food left in a pan in the microwave from the previous occupant and the room could have used a little fusing before our arrival. They came and cleaned the food and the pan the following morning and the microwave, so they were definitely ..."
Reviewed on Jul 26, 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
"The staff was really nice and welcoming, but the room itself could’ve used a little extra TLC. Weren’t there that long but still didn’t expect there to be dirty towels and unkempt carpet. The bed was really comfy though!"
Reviewed on Jul 24, 2026
Courtyard by Marriott St Louis Westport Plaza
Drury Plaza Hotel St. Louis Creve Coeur
"Staff was great air conditioning wasn’t working properly so she got us moved to another room fast"
Reviewed on Jul 25, 2026
Find cheap hotels in Defiance
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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Defiance.
Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Defiance’s 872 hotels. Choose the one that best catches your trip’s tourist drift.
If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $89. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.
While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Defiance. No matter your reason for visiting Defiance, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.
Frequently Asked Questions About Defiance hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Defiance?
With over 872 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $89.
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Finding a cheap car rental deal in Defiance is as easy as scoring cheap hotels in Defiance. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.
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