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Hotels in Defiance

Choose from 828 Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3 out of 5
1088 South Highway Drive, Fenton, MO
  • 41 min drive from August A. Busch Memorial Conservation Area
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,030 reviews)
Nice stay
"We had a wonderful experience at this hotel. The pool was nice along with the hot tub. Very clean. Good breakfast."

Reviewed on Jul 11, 2025

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,964 reviews)
"Check in and my stay were excellent. I was warmly welcomed and was able to settle in for two comfortable nights."

Reviewed on Jul 11, 2025

Hollywood Casino & Hotel St. Louis
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Days Inn and Suites by Wyndham St. Louis/Westport Plaza
2.5 out of 5
1970 Craig Rd, Maryland Heights, MO
  • 28 min drive from August A. Busch Memorial Conservation Area
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
4.6/10 (1,012 reviews)
"Lots of dinning options close."

Reviewed on Jun 21, 2025

Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Wingate by Wyndham St. Louis/Fenton Route 66
Wingate by Wyndham St. Louis/Fenton Route 66
3 out of 5
1100 S Highway Dr, Fenton, MO
  • 41 min drive from August A. Busch Memorial Conservation Area
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,027 reviews)
"Staff is great."

Reviewed on Jul 12, 2025

Wingate by Wyndham St. Louis/Fenton Route 66
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3 out of 5
13639 Riverport Dr, Maryland Heights, MO
  • 26 min drive from August A. Busch Memorial Conservation Area
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.2/10 Good! (1,006 reviews)
"Not bad for what it is pool could have been bigger loved the patio bbq area comfortable beds"

Reviewed on Jul 12, 2025

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
4.5 out of 5
1 Ameristar Blvd, St. Charles, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,001 reviews)
"I love staying at the Ameristar on my visits to STL. The rooms are so spacious and luxurious."

Reviewed on Jul 6, 2025

Ameristar Casino Resort and Spa
The Wildwood Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
  • 26 min drive from August A. Busch Memorial Conservation Area
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,544 reviews)
Would definitely stay again
"Breakfast was fresh and breakfast area was clean. Plenty of tables during a busy time of morning. I didn't try the indoor pool but other guests seemed to be enjoying this amenity and I will try it on my next visit. Loads of parking in a quiet area. Beautiful small town. Starbucks was very close as ..."

Reviewed on Jul 11, 2025

The Wildwood Hotel
La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
3 out of 5
11805 Lackland Rd, Maryland Heights, MO
  • 29 min drive from August A. Busch Memorial Conservation Area
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,018 reviews)
"This location is very clean and has great staff"

Reviewed on Jul 12, 2025

La Quinta Inn & Suites by Wyndham St. Louis Westport
Relax Inn Saint Charles
Relax Inn Saint Charles
2 out of 5
3800 Harry S Truman Blvd, St. Charles, MO
  • 20 min drive from August A. Busch Memorial Conservation Area
Stay at this motel in St. Charles. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the clean rooms in our reviews. Popular attractions ...
6.4/10 (928 reviews)
"In need of some upgrades. Still using blankets from the 60's. Fridge was gross. Ice machine was down. On top of that I left my airpods. I called to see if they could ship it to me and they said no. I offered to pay for it and they said no."

Reviewed on Jul 10, 2025

Relax Inn Saint Charles
Hyatt Place St. Louis/Chesterfield
Hyatt Place St. Louis/Chesterfield
3 out of 5
333 Chesterfield Center East, Chesterfield, MO
  • 21 min drive from August A. Busch Memorial Conservation Area
Stay at this 3-star business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,012 reviews)
"Nice stay. Clean room. Comfortable bed. No issues."

Reviewed on Jul 11, 2025

Hyatt Place St. Louis/Chesterfield
Courtyard by Marriott St Louis Westport Plaza
Courtyard by Marriott St Louis Westport Plaza
3 out of 5
11888 Westline Industrial Dr, Maryland Heights, MO
  • 28 min drive from August A. Busch Memorial Conservation Area
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
8.6/10 Excellent! (1,005 reviews)
"Room was nice,clean. And had a balcony. We enjoyed opening the balcony door and using the screen door for fresh air, however it was just a preference to do so not at all a necessary as the room had no negative odor or that dampness we all dread from other hotel stays elsewhere . Had wall mounted ..."

Reviewed on Jul 13, 2025

Courtyard by Marriott St Louis Westport Plaza
Best Western Plus The Charles Hotel
Best Western Plus The Charles Hotel
3 out of 5
1425 South 5th Street, St. Charles, MO
  • 24 min drive from August A. Busch Memorial Conservation Area
Stay at this 3-star business-friendly hotel in St. Charles. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,007 reviews)
Pool closed
"Our only disappointment was that we specifically booked this hotel for its pool and when we got there they told us the pool was down and weren’t sure when it would be back open. Sadly it was closed for our entire stay. They were very vague with any answers about the pool and had no explanation about ..."

Reviewed on Jul 8, 2025

Best Western Plus The Charles Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Defiance

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Frequently Asked Questions About Defiance hotels

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How many hotels are there in Defiance?

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