Search for Cheap Deals on
Hotels in Defiance

Choose from 866 Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
  • 38 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,323 reviews)
"The stay was okay! Hotel was VERY busy and elevators got over crowded quickly as well as the pool area! Hot Tub wasn’t working (which was a huge problem cause I planned on relaxing after a 6 hour drive from Indiana!!"

Reviewed on Jun 2, 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
  • 35 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.4/10 Very Good! (2,214 reviews)
"The room was clean and the staff was very nice"

Reviewed on Jun 1, 2026

Hollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
  • 36 min drive from Chandler Hill Vineyards
Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,002 reviews)
"Great as always!"

Reviewed on May 31, 2026

Ameristar Casino Resort and Spa
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
  • 20 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,657 reviews)
"Very nice staff. Very clean"

Reviewed on Jun 1, 2026

The Wildwood Hotel
La Quinta Inn & Suites by Wyndham St. Louis Westport

La Quinta Inn & Suites by Wyndham St. Louis Westport

3 out of 5
11805 Lackland Rd Maryland Heights MO
  • 36 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free WiFi, free parking, and a free airport shuttle. Our guests praise the helpful staff ...
7.2/10 Good! (1,122 reviews)
"When we walked in the floor was sticky and smelled like pee and our tv wasn’t working. When I expressed this to the staff they gave us a number to the tv company and said someone would mop. When we came back we could tell they mopped but there was still a smell. Throughout our stay some of the lights ..."

Reviewed on May 31, 2026

La Quinta Inn & Suites by Wyndham St. Louis Westport
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 out of 5
7850 Veterans Memorial Parkway St. Peters MO
  • 31 min drive from Chandler Hill Vineyards
Stay at this hotel in St. Peters. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Bowlero St. Peters and CarShield Field are located ...
8.6/10 Excellent! (141 reviews)
"Staff was very friendly and room was very clean"

Reviewed on May 31, 2026

WoodSpring Suites St Peters-OFallon
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

3 out of 5
5 Lambert Drury Place (I-44 & 141) Valley Park MO
  • 36 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Valley Park. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,002 reviews)
"The stay was good overall. My main feedback is that the rooms feel outdated, and the beds/pillows were not very comfortable. While we had an enjoyable stay, we expected a higher level of luxury for the price we paid. That said, the experience was satisfactory overall."

Reviewed on May 30, 2026

Drury Inn & Suites Southwest St. Louis
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
11228 Lone Eagle Dr Bridgeton MO
  • 41 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,003 reviews)
"Super loud inside and in the room. You can always hear the pool crowd. Also our room clearly had water damage in the bathroom and has just been patched up."

Reviewed on May 31, 2026

Crowne Plaza St. Louis Airport by IHG
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 out of 5
1147 Technology Drive O'Fallon MO
  • 16 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9/10 Wonderful! (1,012 reviews)
"The hotel was clean and the beds are comfortable! Staff were friendly and helpful"

Reviewed on Jun 1, 2026

Sleep Inn & Suites O'Fallon MO - Technology Drive
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
  • 24 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,170 reviews)
"Incredible stay!!"

Reviewed on May 30, 2026

Drury Plaza Hotel St. Louis Chesterfield
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
  • 38 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (1,237 reviews)
"Clean room, good staff, breakfast OK."

Reviewed on Jun 1, 2026

Wingate by Wyndham St. Louis/Fenton Route 66
Courtyard by Marriott St Louis Westport Plaza

Courtyard by Marriott St Louis Westport Plaza

3 out of 5
11888 Westline Industrial Dr Maryland Heights MO
  • 36 min drive from Chandler Hill Vineyards
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,003 reviews)
"Nice hotel. Convenient to restaurants & the interstate. Does not have a pool."

Reviewed on Jun 1, 2026

Courtyard by Marriott St Louis Westport Plaza
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Defiance

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Defiance hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Defiance.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Defiance’s 866 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $94. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Defiance. No matter your reason for visiting Defiance, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Defiance hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Defiance for as low as $94.

How many hotels are there in Defiance?

With over 866 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $94.

How to find cheap car rentals in Defiance?

Finding a cheap car rental deal in Defiance is as easy as scoring cheap hotels in Defiance. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.