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Defiance

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Defiance Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, May 13 - Tue, Jun 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, found 2 hours ago
$56
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Wed, May 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 2, priced at $56 found 2 hours ago
Frontier Airlines
Tue, Jun 2 - Wed, Jun 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$61 Roundtrip, found 8 hours ago
$61
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 17, priced at $61 found 8 hours ago
Frontier Airlines
Wed, May 20 - Mon, Jun 1
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$62 Roundtrip, found 8 hours ago
$62
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Wed, May 20 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Jun 1, priced at $62 found 8 hours ago
Frontier Airlines
Thu, Jun 4 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$67 Roundtrip, found 13 hours ago
$67
Roundtrip
found 13 hours ago
Select Frontier Airlines flight, departing Thu, Jun 4 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $67 found 13 hours ago
Frontier Airlines
Tue, Jun 2 - Tue, Jun 9
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 5 hours ago
$88
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Tue, Jun 9, priced at $88 found 5 hours ago
Frontier Airlines
Sat, May 9 - Fri, May 15
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 2 hours ago
$117
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sat, May 9 from Denver Intl. to Lambert-St. Louis Intl., returning Fri, May 15, priced at $117 found 2 hours ago
American Airlines
Tue, May 12 - Wed, May 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$119 Roundtrip, just found
$119
Roundtrip
just found
Select American Airlines flight, departing Tue, May 12 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, May 13, priced at $119 just found
Delta
Wed, Apr 29 - Tue, May 5
MSP
Minneapolis - St. Paul Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 5 hours ago
$137
Roundtrip
found 5 hours ago
Select Delta flight, departing Wed, Apr 29 from Minneapolis - St. Paul Intl. to Lambert-St. Louis Intl., returning Tue, May 5, priced at $137 found 5 hours ago
Frontier Airlines
Thu, Apr 30 - Wed, May 13
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$153 Roundtrip, found 20 hours ago
$153
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Thu, Apr 30 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Wed, May 13, priced at $153 found 20 hours ago
United
Tue, May 12 - Wed, May 13
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$153 Roundtrip, just found
$153
Roundtrip
just found
Select United flight, departing Tue, May 12 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, May 13, priced at $153 just found
Frontier Airlines
Tue, May 12 - Wed, May 27
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, May 12 from San Francisco Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $199 found 1 day ago
Frontier Airlines
Tue, Jun 16 - Tue, Jun 16
PHX
Sky Harbor Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 1 day ago
$210
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Jun 16 from Sky Harbor Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $210 found 1 day ago
Delta
Tue, Jun 9 - Wed, Jun 10
DAL
Love Field
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 13 hours ago
$257
Roundtrip
found 13 hours ago
Select Delta flight, departing Tue, Jun 9 from Love Field to Lambert-St. Louis Intl., returning Wed, Jun 10, priced at $257 found 13 hours ago
Frontier Airlines
Thu, Apr 23 - Fri, May 22
SJC
Norman Y. Mineta San Jose Intl.
STL
Lambert-St. Louis Intl.
$296 Roundtrip, found 20 hours ago
$296
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Thu, Apr 23 from Norman Y. Mineta San Jose Intl. to Lambert-St. Louis Intl., returning Fri, May 22, priced at $296 found 20 hours ago
Alaska Airlines
Wed, Apr 29 - Tue, May 12
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$327 Roundtrip, found 8 hours ago
$327
Roundtrip
found 8 hours ago
Select Alaska Airlines flight, departing Wed, Apr 29 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, May 12, priced at $327 found 8 hours ago
Hawaiian Airlines
Sat, Apr 11 - Tue, Apr 21
SFO
San Francisco Intl.
STL
Lambert-St. Louis Intl.
$810 Roundtrip, found 20 hours ago
$810
Roundtrip
found 20 hours ago
Select Hawaiian Airlines flight, departing Sat, Apr 11 from San Francisco Intl. to Lambert-St. Louis Intl., returning Tue, Apr 21, priced at $810 found 20 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$56

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.4/10 Very Good! (2,196 reviews)
I liked the place I got big suite for my wife Birthday the jets on the Jacuzzi don't work it was kind of disappointing.

Reviewed on Apr 7, 2026

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Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,187 reviews)
Clean room. Staff was very nice. The breakfast was really good and well maintained. The pool and hottub were great. They had popcorn and soda in the lobby from 3-7 which was a great added bonus.

Reviewed on Apr 8, 2026

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9.2/10 Wonderful! (1,626 reviews)
Nice hotel in a nice area! We had 3 adults in 3 separate rooms with 2 dogs along, and everything was great. We walked across the street one day to catch a movie at the theater. Another day, I walked to the Starbucks close by. One suggestion - they need to update the pictures of the hotel on the internet. ...

Reviewed on Apr 7, 2026

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The Wildwood Hotel
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms in our reviews. ...
8.4/10 Very Good! (999 reviews)
The room was great and clean. This was supposed to have a pool and spa but it wasn’t open or available

Reviewed on Apr 7, 2026

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Ameristar Casino Resort and Spa
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,124 reviews)
Rooms were clean and the complimentary breakfast and dinner was quite nice

Reviewed on Apr 7, 2026

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Drury Plaza Hotel St. Louis Chesterfield
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.6/10 Good! (1,001 reviews)
Decent for the price like i said on the other review pool water was too cold and extremely too much chlorine also they didnt have blankets upon request. Other than that pretty clean and the upkeep was nice didnt have to pay for parking also serves breakfast in the morning oh another thing i forgot ...

Reviewed on Apr 8, 2026

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Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

3.5 out of 5
11228 Lone Eagle Dr Bridgeton MO
Book a stay at this business-friendly hotel in Bridgeton. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the helpful staff ...
8/10 Very Good! (1,002 reviews)
Yes

Reviewed on Apr 6, 2026

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Crowne Plaza St. Louis Airport by IHG
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

3 out of 5
5 Lambert Drury Place (I-44 & 141) Valley Park MO
Book a stay at this business-friendly hotel in Valley Park. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,009 reviews)
Rooms where cleaned. Easy check in. Family friendly. Wifi was also good. We will be staying here again.

Reviewed on Apr 7, 2026

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Drury Inn & Suites Southwest St. Louis
See all 873 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.