Search Cheap Flights toDefiance
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Defiance Flights as Low as $70
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Fri, Jul 11 - Sun, Jul 13
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$70 Roundtrip, found 3 days ago
$70
Roundtrip
found 3 days ago
Thu, Jul 10 - Thu, Jul 17
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$71 Roundtrip, found 3 days ago
$71
Roundtrip
found 3 days ago
Sat, Jul 19 - Sat, Jul 26
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, just found
$114
Roundtrip
just found
Fri, Jul 18 - Tue, Aug 5
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$129 Roundtrip, found 5 hours ago
$129
Roundtrip
found 5 hours ago
Tue, Aug 26 - Tue, Aug 26
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$134 Roundtrip, found 8 hours ago
$134
Roundtrip
found 8 hours ago
Tue, Sep 2 - Wed, Sep 3
MSY
Louis Armstrong New Orleans Intl.
STL
Lambert-St. Louis Intl.
$145 Roundtrip, found 7 hours ago
$145
Roundtrip
found 7 hours ago
Mon, Oct 6 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$149 Roundtrip, found 1 day ago
$149
Roundtrip
found 1 day ago
Mon, Oct 6 - Tue, Oct 14
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$157 Roundtrip, found 7 hours ago
$157
Roundtrip
found 7 hours ago
Wed, Aug 27 - Thu, Sep 4
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, just found
$180
Roundtrip
just found
Tue, Jul 22 - Tue, Jul 22
DAL
Love Field
STL
Lambert-St. Louis Intl.
$195 Roundtrip, found 15 hours ago
$195
Roundtrip
found 15 hours ago
Tue, Nov 18 - Thu, Nov 20
SAT
San Antonio Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 15 hours ago
$210
Roundtrip
found 15 hours ago
Wed, Jul 9 - Sat, Jul 12
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$214 Roundtrip, found 15 hours ago
$214
Roundtrip
found 15 hours ago
Wed, Jul 23 - Mon, Jul 28
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$246 Roundtrip, found 5 hours ago
$246
Roundtrip
found 5 hours ago
Wed, Jul 23 - Tue, Jul 29
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$254 Roundtrip, found 5 hours ago
$254
Roundtrip
found 5 hours ago
Mon, Sep 22 - Thu, Sep 25
SAN
San Diego Intl.
STL
Lambert-St. Louis Intl.
$265 Roundtrip, found 6 hours ago
$265
Roundtrip
found 6 hours ago
Tue, Sep 23 - Wed, Sep 24
CLD
McClellan-Palomar
STL
Lambert-St. Louis Intl.
$319 Roundtrip, found 5 days ago
$319
Roundtrip
found 5 days ago
Cheap Flights to Defiance
Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.
Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.
Frequently Asked Questions About flights to Defiance
Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.
So all you have to worry about is where you’re headed after the STL airport.
What is the cheapest month to fly to Defiance?
Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in July, but when you book your flight on Hotwire, savings are always in season.
How many airlines fly to Defiance?
Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 13 to choose from for your flight to Defiance.
What airport is best to fly into Defiance?
When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.
How much are flights to Defiance?
Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $70, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.
How to get cheap flights to Defiance?
The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $70 right now, why wait?
Destination airport | Lambert-St. Louis Intl. |
Destination airport IATA code | STL |
Roundtrip price | $70 |
Last Minute Hotel Deals in Defiance
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive, Maryland Heights, MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
8.2/10 Very Good! (1,923 reviews)
"We stayed at this property because it was close to a concert venue. The only issue we ran into was my sister is extremely claustrophobic and does not do elevators. Any other hotel we’ve been to she just takes the stairs. At this hotel, they told us the stairs are for staff only because of security ..."
Reviewed on Jun 14, 2025
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
13639 Riverport Dr, Maryland Heights, MO
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
7.2/10 Good! (1,005 reviews)
"Price decently minus Saturday nights."
Reviewed on Jun 12, 2025
Ameristar Casino Resort and Spa
1 Ameristar Blvd, St. Charles, MO
Stay at this 4.5-star luxury hotel in St. Charles. Enjoy an outdoor pool, a full-service spa, and 6 restaurants. Our guests praise the clean rooms and the property ...
8.2/10 Very Good! (1,010 reviews)
"We really liked the room and property. A few things to keep in mind. We were there on a Thursday night and the bars and restaurants close at 9 pm. If you want any food or drinks after you have to go into the casino. I’m assuming the casino allows smoking. The smell of smoke from the casino is very ..."
Reviewed on Jun 13, 2025
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive, Fenton, MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,003 reviews)
"Everything was fine"
Reviewed on Jun 11, 2025
Wingate by Wyndham St. Louis/Fenton Route 66
1100 S Highway Dr, Fenton, MO
Stay at this 3-star business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.4/10 Very Good! (1,006 reviews)
"Clean quiet nice pool . Concierge Nicky was the best very helpful and accommodating."
Reviewed on Jun 12, 2025
La Quinta Inn & Suites by Wyndham St. Louis Westport
11805 Lackland Rd, Maryland Heights, MO
Stay at this 3-star business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.2/10 Good! (1,002 reviews)
"Good places to stay"
Reviewed on Jun 11, 2025
The Wildwood Hotel
2801 Fountain Pl, Wildwood, MO
Stay at this 3.5-star business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
9/10 Wonderful! (1,531 reviews)
"The Hotel was clean and comfortable. Staff was friendly and helpful. Pool area was clean and well maintained. Room was clean and comfortable. One suggestion is to have scrambled eggs and bacon, sausage. More hot food is needed for breakfast. Overall very nice Hotel."
Reviewed on Jun 13, 2025
Sonesta ES Suites St. Louis - Chesterfield
15431 Conway Rd, Chesterfield, MO
Stay at this hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
8/10 Very Good! (1,002 reviews)
"The size of the room was so perfect, allowing for a small walk in kitchen and room for a couch in front of the tv. It felt more like a small apartment, bigger than my first apartment in1975!"
Reviewed on Jun 12, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotels
- Hollywood Casino & Hotel St. Louis
- Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
- Ameristar Casino Resort and Spa
- La Quinta Inn & Suites by Wyndham St. Louis Westport
- The Wildwood Hotel
- Days Inn and Suites by Wyndham St. Louis/Westport Plaza
- Elimwood Hotel, A Ramada by Wyndham
- Holiday Inn St. Louis West Six Flags by IHG
- Comfort Inn St. Louis - Westport Event Center
- Crowne Plaza St. Louis Airport by IHG
- Hyatt Place St. Louis/Chesterfield