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Defiance

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Defiance Flights as Low as $58

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Fri, Oct 2 - Fri, Oct 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 3 days ago
$58
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Fri, Oct 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 16, priced at $58 found 3 days ago
Frontier Airlines
Wed, Sep 16 - Wed, Sep 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$75 Roundtrip, just found
$75
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, Sep 16 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 30, priced at $75 just found
Frontier Airlines
Mon, Sep 14 - Sat, Sep 26
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$80 Roundtrip, just found
$80
Roundtrip
just found
Select Frontier Airlines flight, departing Mon, Sep 14 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Sep 26, priced at $80 just found
Frontier Airlines
Wed, Sep 16 - Wed, Sep 23
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 10 hours ago
$88
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Wed, Sep 16 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 23, priced at $88 found 10 hours ago
Delta
Sat, Oct 31 - Sat, Oct 31
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$112 Roundtrip, found 1 day ago
$112
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Oct 31 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Oct 31, priced at $112 found 1 day ago
Southwest Airlines
Wed, Oct 28 - Wed, Nov 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$117 Roundtrip, just found
$117
Roundtrip
just found
Select Southwest Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $117 just found
Frontier Airlines
Fri, Oct 30 - Thu, Nov 19
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$158 Roundtrip, found 19 hours ago
$158
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Fri, Oct 30 from Dallas-Fort Worth Intl. to Lambert-St. Louis Intl., returning Thu, Nov 19, priced at $158 found 19 hours ago
American Airlines
Wed, Oct 28 - Wed, Nov 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$159 Roundtrip, just found
$159
Roundtrip
just found
Select American Airlines flight, departing Wed, Oct 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Nov 4, priced at $159 just found
United
Tue, Oct 27 - Thu, Oct 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$170 Roundtrip, just found
$170
Roundtrip
just found
Select United flight, departing Tue, Oct 27 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Oct 29, priced at $170 just found
Frontier Airlines
Mon, Nov 2 - Sat, Nov 7
MCO
Orlando Intl.
STL
Lambert-St. Louis Intl.
$176 Roundtrip, just found
$176
Roundtrip
just found
Select Frontier Airlines flight, departing Mon, Nov 2 from Orlando Intl. to Lambert-St. Louis Intl., returning Sat, Nov 7, priced at $176 just found
Frontier Airlines
Sat, Sep 19 - Mon, Sep 21
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$181 Roundtrip, found 18 hours ago
$181
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sat, Sep 19 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Mon, Sep 21, priced at $181 found 18 hours ago
Frontier Airlines
Mon, Oct 5 - Wed, Oct 7
FLL
Fort Lauderdale - Hollywood Intl.
STL
Lambert-St. Louis Intl.
$211 Roundtrip, found 1 hour ago
$211
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Mon, Oct 5 from Fort Lauderdale - Hollywood Intl. to Lambert-St. Louis Intl., returning Wed, Oct 7, priced at $211 found 1 hour ago
Frontier Airlines
Wed, Sep 23 - Mon, Sep 28
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$211 Roundtrip, just found
$211
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, Sep 23 from Tampa Intl. to Lambert-St. Louis Intl., returning Mon, Sep 28, priced at $211 just found
Southwest Airlines
Thu, Oct 29 - Mon, Nov 16
DAL
Love Field
STL
Lambert-St. Louis Intl.
$237 Roundtrip, just found
$237
Roundtrip
just found
Select Southwest Airlines flight, departing Thu, Oct 29 from Love Field to Lambert-St. Louis Intl., returning Mon, Nov 16, priced at $237 just found
Frontier Airlines
Fri, Oct 2 - Mon, Oct 5
GRR
Gerald R. Ford Intl.
STL
Lambert-St. Louis Intl.
$244 Roundtrip, found 11 hours ago
$244
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Fri, Oct 2 from Gerald R. Ford Intl. to Lambert-St. Louis Intl., returning Mon, Oct 5, priced at $244 found 11 hours ago
Bargain Flight
Fri, Sep 25 - Sat, Sep 26
BDL
Bradley Intl.
STL
Lambert-St. Louis Intl.
$282 Roundtrip, found 20 hours ago
$282
Roundtrip
found 20 hours ago
Select Bargain Flight flight, departing Fri, Sep 25 from Bradley Intl. to Lambert-St. Louis Intl., returning Sat, Sep 26, priced at $282 found 20 hours ago

Cheap Flights to Defiance

Fall in love at first flight with your vacation to Defiance by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Defiance on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Defiance, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Defiance

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Defiance with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Defiance?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Defiance are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Defiance?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Defiance.

What airport is best to fly into Defiance?

When you’re planning your trip to Defiance, convenience is the name of the game. Luckily, Defiance Spirit of St. Louis Airport is nearby so you can deplane and get going on checking off everything on your Defiance must-do list.

How much are flights to Defiance?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Defiance on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $58, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Defiance?

The trick to saving a stack of cash on your flight to Defiance? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $58 right now, why wait?

Defiance Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$58

Last Minute Hotel Deals in Defiance

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Book a stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the ...
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Hollywood Casino & Hotel St. Louis
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,547 reviews)
"Wasn't sure what to expect when we pulled into hotel but looks can be deceiving. Staff was great, check in easy, room was clean, cold, amazing beds, even the shampoo and conditioner were fantastic. After a 16 hour drive it was a welcome and great choice."

Reviewed on Aug 26, 2026

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Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Book a stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants, and a casino. Our guests praise the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (1,028 reviews)
"Great location and atmosphere! Rooms are so spacious and nice. Will definitely stay again!"

Reviewed on Aug 23, 2026

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Ameristar Casino Resort and Spa
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Book a stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the convenient ...
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The Wildwood Hotel
Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

2.5 out of 5
1970 Craig Rd Maryland Heights MO
Stay at this hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
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Days Inn and Suites by Wyndham St. Louis/Westport Plaza
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

3 out of 5
355 Chesterfield Ctr Chesterfield MO
Book a stay at this business-friendly hotel in Chesterfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
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Drury Plaza Hotel St. Louis Chesterfield
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

4 out of 5
1335 S Lindbergh Blvd Frontenac MO
Book a stay at this business-friendly hotel in Frontenac. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (1,001 reviews)
"The staff was very helpful"

Reviewed on Aug 26, 2026

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Hilton St. Louis Frontenac
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3 out of 5
1100 S Highway Dr Fenton MO
Book a stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (1,329 reviews)
"Don’t let the name fool you. Just because it says Howard Johnson doesn’t mean it’s a good location tight off the freeway just too much movement and traffic in and out of the building."

Reviewed on Aug 26, 2026

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Wingate by Wyndham St. Louis/Fenton Route 66
See all 878 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.