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Defiance Vacations

Pack those stellar shades. We have Defiance vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Defiance – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Defiance vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Defiance

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Defiance vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Defiance well.

Top Hotel Deals

See all 142 Properties in Defiance
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive, Maryland Heights
    3.5 out of 5.0
     
     

    Situated near the airport, this hotel is 1.3 mi (2.1 km) from Hollywood Casino Amphitheatre and within 9 mi (15 km) of Historic Main Street and Lindenwood University. ...

    Hollywood Casino & Hotel St. Louis$93

    Hollywood Casino & Hotel St. Louis$93
    Days Inn by Wyndham St. Louis/Westport MO

    Days Inn by Wyndham St. Louis/Westport MO

    1970 Craig Rd, Maryland Heights
      2.5 out of 5.0
       
       

      Near I-270, this suburban St Louis hotel is a half-mile from West Port Plaza, 4 miles from UMB Bank Pavilion, and 6 miles from Lambert-St Louis International ...

      Days Inn by Wyndham St. Louis/Westport MO$76

      Days Inn by Wyndham St. Louis/Westport MO$76
      La Quinta Inn & Suites St. Louis Airport - Riverport

      La Quinta Inn & Suites St. Louis Airport - Riverport

      13615 Riverport Drive, Maryland Heights
        3.0 out of 5.0
         
         

        Situated near the airport, this hotel is 0.5 mi (0.9 km) from Hollywood Casino Amphitheatre and within 6 mi (10 km) of Historic Aircraft Restoration Museum and ...

        La Quinta Inn & Suites St. Louis Airport - Riverport$93

        La Quinta Inn & Suites St. Louis Airport - Riverport$93
        Pear Tree Inn St. Louis Fenton

        Pear Tree Inn St. Louis Fenton

        1100 S Highway Dr, Fenton
          2.5 out of 5.0
           
           

          Situated in the suburbs, this hotel is 1.4 mi (2.3 km) from LIFECHURCH and within 6 mi (10 km) of Laumeier Sculpture Park and Swing-A-Round Fun Town. Powder ...

          Pear Tree Inn St. Louis Fenton$80

          Pear Tree Inn St. Louis Fenton$80
          SureStay Plus Hotel by Best Western St. Louis Airport

          SureStay Plus Hotel by Best Western St. Louis Airport

          11380 Natural Bridge Rd, Bridgeton
            2.5 out of 5.0
             
             

            Situated near the airport, this hotel is 1.1 mi (1.8 km) from Payne-Gentry Historical House and within 6 mi (10 km) of Westport Plaza and James S. McDonnell ...

            SureStay Plus Hotel by Best Western St. Louis Airport$62

            SureStay Plus Hotel by Best Western St. Louis Airport$62
            Wingate by Wyndham St. Charles MO

            Wingate by Wyndham St. Charles MO

            32 Research Park Circle, St. Charles
              3.0 out of 5.0
               
               

              Situated in the suburbs, this hotel is 0.2 mi (0.3 km) from Missouri Bluffs Golf Course and within 6 mi (10 km) of St. Louis Premium Outlets and Weldon Spring ...

              Wingate by Wyndham St. Charles MO$84

              Wingate by Wyndham St. Charles MO$84
              Drury Plaza Hotel St. Louis Chesterfield

              Drury Plaza Hotel St. Louis Chesterfield

              355 Chesterfield Ctr, Chesterfield
                3.0 out of 5.0
                 
                 

                Located in the heart of Chesterfield, this hotel is within 2 mi (3 km) of Westfield Chesterfield Mall, Sophia M. Sachs Butterfly House, and Faust Park. Taubman ...

                Drury Plaza Hotel St. Louis Chesterfield$120

                Drury Plaza Hotel St. Louis Chesterfield$120
                Motel 6 Hazelwood

                Motel 6 Hazelwood

                5781 Campus Ct, Hazelwood
                  2.0 out of 5.0
                   
                   

                  Situated near the airport, this motel is 2.5 mi (4 km) from St. Louis Mills Mall and within 6 mi (10 km) of James S. McDonnell Prologue Room and Payne-Gentry ...

                  Motel 6 Hazelwood$36

                  Motel 6 Hazelwood$36
                  Motel 6 Maryland Heights, MO

                  Motel 6 Maryland Heights, MO

                  12330 Dorsett Rd, Maryland Heights
                    2.0 out of 5.0
                     
                     

                    Situated in Maryland Heights, this hotel is 0.1 mi (0.1 km) from Westport Plaza and within 6 mi (10 km) of Creve Coeur Golf Club and Payne-Gentry Historical ...

                    Motel 6 Maryland Heights, MO$43

                    Motel 6 Maryland Heights, MO$43
                    The Wildwood Hotel

                    The Wildwood Hotel

                    2801 Fountain Pl, Wildwood
                      3.5 out of 5.0
                       
                       

                      Situated in Wildwood, this hotel is within 9 mi (15 km) of Dr. Edmund A. Babler Memorial State Park, Hidden Valley Ski Resort, and Babler State Park. Westfield ...

                      The Wildwood Hotel$90

                      The Wildwood Hotel$90

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.