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Kahler Grand Hotel
"The bathroom stinked and it was next to the bed,"
Reviewed on Aug 23, 2026
Kahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
"From the outside the hotel looks outdated. The rooms were good outdated but clean. A mile away from downtown area. Attached to Dave’s barbecue which was good. Grocery and laundry nearby and on the bus route. Hotel staff helpful with a coffee and a breakfast served every morning I would definitely ..."
Reviewed on Aug 23, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
"the pool deck was very slippery."
Reviewed on Aug 23, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
"No hot water in the morning for my shower!"
Reviewed on Aug 23, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached ..."
Reviewed on Aug 23, 2026
The Berkman
"This was a very nice hotel located in downtown. It’s directly across from Mayo. The concierge checked each guest in and very helpful. This nice touch made the experience extra special."
Reviewed on Aug 22, 2026
Hyatt House Rochester/Mayo Clinic Area
Hampton Inn Rochester-South
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Find cheap hotels in Byron
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Frequently Asked Questions About Byron hotels
Where can I find the best last-minute travel deals?
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How many hotels are there in Byron?
With over 381 hotels in Byron, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $84.
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