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Kahler Grand Hotel
You can walk to Mayo with out going outside. There is also a convenient store on the Subway level a few step from the elevater that has snacks, cold beverages and fresh popcorn. Walk a little farther and you can get Starbucks coffee. You can also get some Italian food from the best Italian restaurant ...
Reviewed on Mar 24, 2026
Aspen Suites
Clean room, friendly staff. We would stay here again.
Reviewed on Mar 21, 2026
Kahler Inn and Suites - Mayo Clinic Area
Great breakfast!
Reviewed on Mar 24, 2026
EVEN Hotel Rochester - Mayo Clinic Area by IHG
If you're coming in from the airport (RST) use Rochester Shuttle service. It's reasonably priced and they are always on time.
Reviewed on Mar 24, 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Yes
Reviewed on Mar 23, 2026
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Clean, reasonably comfortable, and priced fairly
Reviewed on Mar 24, 2026
The Berkman
This hotel is great for families that need to stay close to St Mary's or Mayo clinics. The rooms were comfy and pantry was priced decently for any last minute needs. It was very clean, easy to acces, amd walking distance to great restaurants.
Reviewed on Mar 24, 2026
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
The rooms were very clean. My bed was comfortable however we were on the ground floor and the noise in the afternoon outside our window of dripping water was unbelievable. The breakfast was very satisfying however, when I asked for what my bill would be the silver haired man on dayshift at the front ...
Reviewed on Mar 21, 2026
AmericInn by Wyndham Rochester Near Mayo Clinic
The rooms were clean. The staff was professional and they took that extra minute to get to know you. I highly recommend this for a stay short term or long-term.
Reviewed on Mar 24, 2026
Aspen Select
Aspen Select is a solid choice near St Mary's hospital. The staff are kind and attentive and although the outside may not be as new as other options, the rooms are comfortable with pullouts and recliners and amenities.
Reviewed on Mar 20, 2026
Spark by Hilton Rochester South
Clean room soft bed and pillows
Reviewed on Mar 23, 2026
Hyatt House Rochester/Mayo Clinic Area
Perfect for visiting Mayo Clinic
Reviewed on Mar 18, 2026
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