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Hotels in Southern Minnesota

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Choose from 1140 Southern Minnesota Hotel Deals

Kahler Grand Hotel
Kahler Grand Hotel
3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,400 reviews)
"Had a great stay. The location has great access to Mayo Clinic. The hotel is connected by the underground and skywalk systems. It has great restaurants close by- within a block and 2 inside the hotel. The room was clean and the staff changed towels daily. The bathroom was a bit small but that was ..."

Reviewed on Jun 14, 2025

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic
AmericInn by Wyndham Rochester Near Mayo Clinic
3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (889 reviews)
"We like the fact there was a shuttle that went to Mayo Clinic but wish they ran a little longer than 6:15 as we missed that by 5-10min. Also like the restaurant/bar attached and had a great service"

Reviewed on Jun 11, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Hyatt House Rochester/Mayo Clinic Area
Hyatt House Rochester/Mayo Clinic Area
3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (923 reviews)
"Stay went well and location was excellent"

Reviewed on Jun 12, 2025

Hyatt House Rochester/Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area
3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,359 reviews)
"The room was nice and large. Very convenient to Mayo Clinic. They had very few parking spaces and a very low ceiling. I would still highly recommend it."

Reviewed on Jun 12, 2025

Kahler Inn and Suites - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,003 reviews)
"Use great staff!"

Reviewed on Jun 12, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
EVEN Hotel Rochester - Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG
4 out of 5
101 11TH Avenue SW, Suite A, Rochester, MN
  • 17 min walk from Mayo Clinic
Stay at this 4-star business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...
9.4/10 Exceptional! (834 reviews)
"Clean rooms and quiet. Comfortable beds and love the shower."

Reviewed on Jun 6, 2025

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
3 out of 5
401 6th St Sw, Rochester, MN
  • 8 min walk from Mayo Clinic
Stay at this 3-star golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"This is one of our favorites amomgst our many visits to Mayo"

Reviewed on Jun 11, 2025

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (775 reviews)
"Beautiful property, CRAVE was great option for dinner on site. Parking structure under renovation currently. Close to Mayo Clinic and connected to Skyway."

Reviewed on May 19, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Redwood Lodge
Redwood Lodge
2 out of 5
1382 E Bridge St, Redwood Falls, MN
  • 7 hours drive from Mayo Clinic
Stay at this hotel in Redwood Falls. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.8/10 Excellent! (624 reviews)
"Good size rooms. Clean. The rooms with 2 beds are 2 double beds, not queen size. Good breakfast. Thin floors--I found the sound of people tromping above me annoying. Requested a top floor room when I made the reservation but there were none available when I checked in."

Reviewed on Jun 10, 2025

Redwood Lodge
Med City Inn & Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area
2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,002 reviews)
"No complaints. We stay here regularly when we have appointments at the Mayo Clinic and some of the staff relate to us familiarly because of that. Very nice."

Reviewed on Jun 10, 2025

Med City Inn & Suites - Mayo Clinic Area
Country Inn & Suites Rochester South Mayo Clinic
Country Inn & Suites Rochester South Mayo Clinic
3 out of 5
77 Woodlake Drive SE, Rochester, MN
  • 8 min drive from Mayo Clinic
Stay at this 3-star family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.2/10 Very Good! (1,002 reviews)
"Accessible handles helped me a lot in the bathroom"

Reviewed on Jun 12, 2025

Country Inn & Suites Rochester South Mayo Clinic
Aspen Select
Aspen Select
3.5 out of 5
1215 2nd St SW, Rochester, MN
  • 21 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
"Very clean and quiet"

Reviewed on Jun 13, 2025

Aspen Select
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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