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Hotels in Southern Minnesota

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Choose from 1188 Southern Minnesota Hotel Deals

Treasure Island Resort & Casino

Treasure Island Resort & Casino

3 out of 5
5734 Sturgeon Lake Road Welch MN
  • 2 hours drive from Mayo Clinic
Book a stay at this spa hotel in Welch. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Treasure Island Casino and Island Xtreme Bowl ...
8.6/10 Excellent! (394 reviews)
"Easy to find your way around! The music venue is perfect and water park so fun!"

Reviewed on Jun 27, 2026

Treasure Island Resort & Casino
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (2,168 reviews)
"2nd stay at Kahler Grand. Super convenient. Good bed & linens, front desk and valet parking staff are incredibly helpful. Quiet. Our room was small, but adequate. Small bathroom. Multiple restaurant options inside hotel or within easy walk. Charlton & Eisenberg are literally across the street, as ..."

Reviewed on Jun 27, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,601 reviews)
"Room adequate, serious lack of electrical outlets was a problem. Breakfast pretty limited but very good. Wish there was coffee option other than the $10/cup option in the lobby. Staff were very friendly. Housekeeping only on request I don't care about that but some might. Proximity to Mayo is fantastic!!! ..."

Reviewed on Jun 28, 2026

Kahler Inn and Suites - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,004 reviews)
"This hotel isn’t the most luxurious place I’ve stayed, but it’s clean, comfortable, and serves its purpose well. The biggest advantage is its location, it’s incredibly convenient if you’re visiting Mayo Clinic, making appointments and travel much less stressful. The staff was friendly, check-in was ..."

Reviewed on Jun 28, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Med City Inn & Suites - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE Rochester MN
  • 11 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.4/10 Good! (1,064 reviews)
"Good"

Reviewed on Jun 27, 2026

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,004 reviews)
"Difficult review to write The staff was excellent with me, very pleasant and accommodating The reason for my poor review is the location of the hotel situated directly beside the train tracks and crossing. Our first night 3 trains came by the hotel from 12:30am to 6:00am, each one blowing their whistle ..."

Reviewed on Jun 27, 2026

Hyatt House Rochester/Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (958 reviews)
"The beds were very comfortable. The rooms were cozy. The waterslide was a huge hit with my granddaughter. Couldn't keep her out of the pool! The only thing that was an issue was the ice machines were out of ice most of the time. We had to go from machine to machine just to get a full bucket. Overall, ..."

Reviewed on Jun 26, 2026

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

3 out of 5
900 Bruski Dr Winona MN
  • 2 hours drive from Mayo Clinic
Book a stay at this business-friendly hotel in Winona. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Express Suites Riverport Inn & Suites
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,001 reviews)
"I needed to leave my luggage early and retrieve it late: no problem! Also asked about early check in: also no problem! Everyone on staff were overboard nice and helpful."

Reviewed on Jun 26, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,368 reviews)
"M"

Reviewed on Jun 28, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (1,002 reviews)
"This is a well located property, close to restaurants, shopping, and Mayo Clinic. The staff was very understanding of the fluidity of my stay due to appointments at Mayo Clinic. The property doesn't have some of the amenities of other more expensive hotels in the area, but it is a great value for ..."

Reviewed on Jun 25, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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