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Hotels in Southern Minnesota

Choose from 1200 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,886 reviews)
Clean, quiet, wonderful front desk staff, close to Mayo.

Reviewed on Feb 8, 2026

Kahler Grand Hotel
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (1,199 reviews)
Front desk and cleaning staff are so kind and helpful! Rooms are clean and up to date! Comfortable beds and atmosphere! Definitely stay again.

Reviewed on Jan 31, 2026

AmericInn by Wyndham Rochester Near Mayo Clinic
Aspen Suites

Aspen Suites

3 out of 5
1211 2nd Street Rochester MN
  • 21 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (719 reviews)
Everybody was polite. Morning breakfast was similar to other places I have stayed. In the afternoon they have light foods that were also complimentary. Hallways are tight coming off elevator.

Reviewed on Feb 8, 2026

Aspen Suites
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,526 reviews)
The room was comfortable, the bedding, nice. The hotel was quiet at night, but there's massive construction going on in every direction, from which the noise starts at 7:30am. Every hotel in the area would be the same for noise. Breakfast was good except the pancakes were tough like shoe leather, ...

Reviewed on Feb 6, 2026

Kahler Inn and Suites - Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.2/10 Wonderful! (992 reviews)
Could use more staff in hotel. Rooms were ok. Shuttle to Mayo was a little crowded at times.

Reviewed on Feb 3, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (926 reviews)
clean, great customer service, when asked for towels and toilet paper got them fast, no noise complaints

Reviewed on Feb 2, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,002 reviews)
Nice spacious room

Reviewed on Jan 29, 2026

Hyatt House Rochester/Mayo Clinic Area
Hampton Inn Rochester-South

Hampton Inn Rochester-South

2.5 out of 5
1755 S Broadway Rochester MN
  • 4 min drive from Mayo Clinic
Stay at this hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9/10 Wonderful! (1,004 reviews)
Very friendly staff always willing to help. Great breakfast area with evening soup which was wonderful on these cold January nights. Housekeeping did not come one time during our stay and the front desk was accommodating to give us extra towels and supplies we needed for our room.

Reviewed on Feb 3, 2026

Hampton Inn Rochester-South
Brentwood Inn & Suites

Brentwood Inn & Suites

2.5 out of 5
123 Fourth Ave. NW Rochester MN
  • 5 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,000 reviews)
Clean

Reviewed on Jan 27, 2026

Brentwood Inn & Suites
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
401 6th St Sw Rochester MN
  • 8 min walk from Mayo Clinic
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. ...
8.6/10 Excellent! (1,004 reviews)
The hotel was clean. I still do not like your small pillows, but the rest of the bedding were super comfortable. The staff were friendly and helpful.

Reviewed on Jan 29, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE Rochester MN
  • 10 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (370 reviews)
Room was very clean, staff was excellent in every way

Reviewed on Feb 7, 2026

Spark by Hilton Rochester South
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
  • 19 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (961 reviews)
Everything was fine

Reviewed on Feb 2, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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