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Hotels in Southern Minnesota

Choose from 1198 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.4/10 Very Good! (1,963 reviews)
First room the bathtub was full and dirty, second room was dark and the heating until outside the door was VERY loud.

Reviewed on Mar 26, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
  • 3 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,540 reviews)
Breakfast was awesome.

Reviewed on Mar 26, 2026

Kahler Inn and Suites - Mayo Clinic Area
Aspen Suites

Aspen Suites

3 out of 5
1211 2nd Street Rochester MN
  • 21 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (776 reviews)
The staff is incredibly friendly and accommodating. A free shuttle to Mayo Clinic stops right outside the front lobby doors, Mayo St. Mary's Hospital is just across the street, and there are several restaurant options in walking distance from the property. The kitchenette in the suite, complementary ...

Reviewed on Mar 26, 2026

Aspen Suites
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
  • 6 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (968 reviews)
Our room was not very big for a queen size bed. The second floor lobby with no street-level direct access was inconvenient. The hotel shares a lobby with Crave restaurant so there really isn’t a hotel lobby dedicated for guests. The skyway access to Mayo Clinic is very nice and convenient.

Reviewed on Mar 26, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

4 out of 5
101 11TH Avenue SW Rochester MN
  • 17 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
9.4/10 Exceptional! (1,000 reviews)
Very clean. Ɓed was way too soft. The dining menu was limited but good. Had 3 meals there and were very satisfied. Servers were all incredible.

Reviewed on Mar 25, 2026

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw Rochester MN
  • 18 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.6/10 Excellent! (977 reviews)
The rooms were very clean. My bed was comfortable however we were on the ground floor and the noise in the afternoon outside our window of dripping water was unbelievable. The breakfast was very satisfying however, when I asked for what my bill would be the silver haired man on dayshift at the front ...

Reviewed on Mar 21, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE Rochester MN
  • 10 min drive from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (414 reviews)
Clean room soft bed and pillows

Reviewed on Mar 23, 2026

Spark by Hilton Rochester South
Aspen Select

Aspen Select

3.5 out of 5
1215 2nd St SW Rochester MN
  • 21 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,000 reviews)
Aspen Select is a solid choice near St Mary's hospital. The staff are kind and attentive and although the outside may not be as new as other options, the rooms are comfortable with pullouts and recliners and amenities.

Reviewed on Mar 20, 2026

Aspen Select
Brentwood Inn & Suites

Brentwood Inn & Suites

2.5 out of 5
123 Fourth Ave. NW Rochester MN
  • 5 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,002 reviews)
Location is great if Mayo on foot is what you want. Other than that, there’s not much to recommend. I was on 3rd floor and it sounded like an elephant was above me. Breakfast is over at 9 SHARP. It consists of one microwave for anything hot. Stand in line. And, forgot about a second glass of juice, ...

Reviewed on Mar 22, 2026

Brentwood Inn & Suites
Redwood Lodge

Redwood Lodge

2 out of 5
1382 E Bridge St Redwood Falls MN
  • 7 hours drive from Mayo Clinic
Stay at this hotel in Redwood Falls. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
9/10 Wonderful! (825 reviews)
Clean, quiet and friendly staff

Reviewed on Mar 20, 2026

Redwood Lodge
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW Rochester MN
  • 7 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,000 reviews)
Perfectly located near the Mayo Clinic

Reviewed on Mar 26, 2026

Hyatt House Rochester/Mayo Clinic Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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