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Hotels in Southern Minnesota

Choose from 1167 Southern Minnesota Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
  • 2 min walk from Mayo Clinic
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
8.2/10 Very Good! (1,486 reviews)
"Property very amenable to the clinic, rooms are dated and a bit small but comfortable."

Reviewed on Aug 2, 2025

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw, Rochester, MN
  • 26 min walk from Mayo Clinic
Book a stay at this family-friendly motel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,000 reviews)
"Close to where we had to go. The breakfast was good. The air conditioning in the room didn't seem to reach the bed. The pool/ hot tub was out of order."

Reviewed on Jul 28, 2025

Med City Inn & Suites - Mayo Clinic Area
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
1125 2nd St Sw, Rochester, MN
  • 19 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (837 reviews)
"Located right across street from St Mary’s"

Reviewed on Jul 31, 2025

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Spark by Hilton Rochester South

Spark by Hilton Rochester South

3 out of 5
4165 Maine Ave SE, Rochester, MN
  • 10 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (90 reviews)
"Staff were amazing. I have stayed in many places around Rochester. This is by far the best."

Reviewed on Jul 28, 2025

Spark by Hilton Rochester South
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
110 Civic Center Drive NW, Rochester, MN
  • 7 min walk from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (980 reviews)
"The cook who bartended on Wednesday, July 30th was absolutely amazing!"

Reviewed on Aug 1, 2025

Hyatt House Rochester/Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw, Rochester, MN
  • 3 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
7.8/10 Good! (1,383 reviews)
"Clean rings and very friendly employees"

Reviewed on Aug 2, 2025

Kahler Inn and Suites - Mayo Clinic Area
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE, Rochester, MN
  • 11 min drive from Mayo Clinic
Stay at this 3-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,001 reviews)
"Clean, comfortable rooms located in a convenient area close to restaurants, shopping and the interstate."

Reviewed on Aug 1, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S, Rochester, MN
  • 4 min drive from Mayo Clinic
Book a stay at this spa hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the restaurant and the helpful staff in our ...
8/10 Very Good! (956 reviews)
Stayed there to attend medical appoints
"This hotel is older and they have done a nice job updating. It was a good place to stay for what we needed. We were there for medical appointments."

Reviewed on Aug 1, 2025

AmericInn by Wyndham Rochester Near Mayo Clinic
Aspen Select

Aspen Select

3.5 out of 5
1215 2nd St SW, Rochester, MN
  • 21 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
"It was in a great location. Staff was wondering and accomodating."

Reviewed on Jul 29, 2025

Aspen Select
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway, Rochester, MN
  • 6 min walk from Mayo Clinic
Stay at this 3.5-star business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and ...
8.8/10 Excellent! (800 reviews)
"Great location downtown Rochester"

Reviewed on Jul 31, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw, Rochester, MN
  • 5 min drive from Mayo Clinic
Book a stay at this family-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.2/10 Very Good! (675 reviews)
"Oue stay was great and the kids had fun in the pool area."

Reviewed on Jul 29, 2025

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
St James Hotel, a Historic Hotel of America

St James Hotel, a Historic Hotel of America

3.5 out of 5
406 Main St., Red Wing, MN
  • 2 hours drive from Mayo Clinic
Stay at this 3.5-star spa hotel in Red Wing. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the comfy rooms in ...
9/10 Wonderful! (1,001 reviews)
"The hotel is well maintained & very beautiful. The bed & pillows were very comfortable, and the linens very soft. Parking is free & in a garage attached to the hotel. The food in the Scarlet restaurant was delicious. After dinner we walked around downtown Red Wing & along the waterfront. Red Wing ..."

Reviewed on Aug 1, 2025

St James Hotel, a Historic Hotel of America
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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