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Southern Illinois

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Southern Illinois Flights as Low as $186

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Delta
Thu, Nov 26 - Wed, Dec 2
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$186 Roundtrip, found 4 days ago
$186
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Nov 26 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $186 found 4 days ago
Delta
Thu, Nov 26 - Sat, Nov 28
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$257 Roundtrip, found 4 days ago
$257
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Nov 26 from O'Hare Intl. to Lambert-St. Louis Intl., returning Sat, Nov 28, priced at $257 found 4 days ago
Frontier Airlines
Mon, Aug 31 - Mon, Aug 31
RDU
Raleigh - Durham Intl.
STL
Lambert-St. Louis Intl.
$259 Roundtrip, found 5 days ago
$259
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Mon, Aug 31 from Raleigh - Durham Intl. to Lambert-St. Louis Intl., returning Mon, Aug 31, priced at $259 found 5 days ago
Frontier Airlines
Tue, Aug 4 - Mon, Aug 10
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$275 Roundtrip, found 4 days ago
$275
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Aug 4 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Aug 10, priced at $275 found 4 days ago
Delta
Thu, Nov 26 - Thu, Dec 3
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$278 Roundtrip, found 4 days ago
$278
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Nov 26 from O'Hare Intl. to Lambert-St. Louis Intl., returning Thu, Dec 3, priced at $278 found 4 days ago
Bargain Flight
Fri, Aug 28 - Sat, Aug 29
RDU
Raleigh - Durham Intl.
STL
Lambert-St. Louis Intl.
$281 Roundtrip, found 5 days ago
$281
Roundtrip
found 5 days ago
Select Bargain Flight flight, departing Fri, Aug 28 from Raleigh - Durham Intl. to Lambert-St. Louis Intl., returning Sat, Aug 29, priced at $281 found 5 days ago
Bargain Flight
Sat, Aug 29 - Sun, Aug 30
RDU
Raleigh - Durham Intl.
STL
Lambert-St. Louis Intl.
$285 Roundtrip, found 5 days ago
$285
Roundtrip
found 5 days ago
Select Bargain Flight flight, departing Sat, Aug 29 from Raleigh - Durham Intl. to Lambert-St. Louis Intl., returning Sun, Aug 30, priced at $285 found 5 days ago
Frontier Airlines
Tue, Aug 4 - Wed, Aug 5
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$287 Roundtrip, found 4 days ago
$287
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Aug 4 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Aug 5, priced at $287 found 4 days ago
Frontier Airlines
Thu, Jul 30 - Mon, Aug 10
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$290 Roundtrip, found 4 days ago
$290
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Thu, Jul 30 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Aug 10, priced at $290 found 4 days ago
Frontier Airlines
Mon, Aug 3 - Mon, Aug 10
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$295 Roundtrip, found 4 days ago
$295
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Aug 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Aug 10, priced at $295 found 4 days ago
United
Mon, Nov 23 - Mon, Nov 30
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$297 Roundtrip, found 4 days ago
$297
Roundtrip
found 4 days ago
Select United flight, departing Mon, Nov 23 from O'Hare Intl. to Lambert-St. Louis Intl., returning Mon, Nov 30, priced at $297 found 4 days ago
Frontier Airlines
Mon, Aug 3 - Fri, Aug 7
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$302 Roundtrip, found 4 days ago
$302
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Aug 3 from O'Hare Intl. to Lambert-St. Louis Intl., returning Fri, Aug 7, priced at $302 found 4 days ago
Delta
Wed, Nov 25 - Wed, Dec 2
ORD
O'Hare Intl.
STL
Lambert-St. Louis Intl.
$305 Roundtrip, found 4 days ago
$305
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Nov 25 from O'Hare Intl. to Lambert-St. Louis Intl., returning Wed, Dec 2, priced at $305 found 4 days ago
Delta
Sun, Sep 6 - Sat, Sep 19
RDU
Raleigh - Durham Intl.
EVV
Evansville Regional
$338 Roundtrip, found 1 day ago
$338
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Sep 6 from Raleigh - Durham Intl. to Evansville Regional, returning Sat, Sep 19, priced at $338 found 1 day ago
American Airlines
Sat, Aug 8 - Wed, Aug 12
RDU
Raleigh - Durham Intl.
EVV
Evansville Regional
$445 Roundtrip, found 1 day ago
$445
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Aug 8 from Raleigh - Durham Intl. to Evansville Regional, returning Wed, Aug 12, priced at $445 found 1 day ago
American Airlines
Sat, Sep 19 - Tue, Oct 6
ORD
O'Hare Intl.
EVV
Evansville Regional
$475 Roundtrip, found 1 day ago
$475
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Sep 19 from O'Hare Intl. to Evansville Regional, returning Tue, Oct 6, priced at $475 found 1 day ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in November, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Veterans Airport of Southern Illinois Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $186, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $186 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$56

Last Minute Hotel Deals in Southern Illinois

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3.5 out of 5
145 North 44th Street  Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.8/10 Exceptional! (1,745 reviews)
"Really impressed by this hotel. An excellent place to stay for 1 night on our road trip."

Reviewed on Jul 20, 2026

Get rates
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,013 reviews)
"Great overnight stay will definitely recommend"

Reviewed on Jul 21, 2026

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Drury Inn & Suites St. Louis Fairview Heights
Best Western St. Louis Fairview Heights

Best Western St. Louis Fairview Heights

2.5 out of 5
150 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
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Best Western St. Louis Fairview Heights
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,009 reviews)
"Evening kickback and breakfast were great!"

Reviewed on Jul 20, 2026

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Drury Inn & Suites Marion
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
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Drury Inn & Suites St. Louis O'Fallon, IL
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,038 reviews)
"The hotel had a lot sketchy people wandering the parking lot at night. The carpet in the hallways and on the staircase was really dirty. The smoke alarm in the room was missing. In the bathroom the shower wall was coming apart. The people who were actually staying in the hotels looked liked homeless ..."

Reviewed on Jul 21, 2026

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Super 8 by Wyndham O'Fallon
Comfort Suites Fairview Heights - St. Louis

Comfort Suites Fairview Heights - St. Louis

2.5 out of 5
137 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
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Comfort Suites Fairview Heights - St. Louis
Motel 6 Caseyville, IL - Caseyville Il

Motel 6 Caseyville, IL - Caseyville Il

2 out of 5
2431 Old Country Inn Dr Caseyville IL
Stay at this motel in Caseyville. Enjoy free parking, an outdoor pool, and a 24-hour front desk. Popular attractions Pleasant Ridge Park and Cahokia Mounds State ...
6.4/10 (1,004 reviews)
"Air conditioning didn't work, looked dirty."

Reviewed on Jul 21, 2026

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Motel 6 Caseyville, IL - Caseyville Il
See all 1,156 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.