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Southern Illinois

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Southern Illinois Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Tue, Jun 2 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, found 17 hours ago
$56
Roundtrip
found 17 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $56 found 17 hours ago
Frontier Airlines
Sat, May 30 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$62 Roundtrip, found 1 day ago
$62
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 30 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $62 found 1 day ago
Frontier Airlines
Thu, Jun 4 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$64 Roundtrip, just found
$64
Roundtrip
just found
Select Frontier Airlines flight, departing Thu, Jun 4 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $64 just found
Frontier Airlines
Tue, Jun 2 - Wed, Jun 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$67 Roundtrip, found 20 hours ago
$67
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 17, priced at $67 found 20 hours ago
Frontier Airlines
Thu, May 14 - Sat, May 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$68 Roundtrip, found 1 day ago
$68
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, May 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $68 found 1 day ago
Frontier Airlines
Mon, Jun 1 - Wed, Jun 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$73 Roundtrip, found 20 hours ago
$73
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Mon, Jun 1 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 17, priced at $73 found 20 hours ago
Frontier Airlines
Thu, May 14 - Mon, May 25
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$79 Roundtrip, found 1 day ago
$79
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, May 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, May 25, priced at $79 found 1 day ago
Frontier Airlines
Fri, May 15 - Tue, Jun 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$82 Roundtrip, found 1 hour ago
$82
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Fri, May 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 2, priced at $82 found 1 hour ago
Frontier Airlines
Tue, May 26 - Wed, Jun 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 15 hours ago
$84
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Tue, May 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $84 found 15 hours ago
Frontier Airlines
Fri, May 15 - Sat, May 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 1 hour ago
$88
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Fri, May 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $88 found 1 hour ago
Delta
Tue, May 26 - Wed, Jun 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, found 15 hours ago
$180
Roundtrip
found 15 hours ago
Select Delta flight, departing Tue, May 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $180 found 15 hours ago
United
Tue, May 26 - Wed, Jun 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 15 hours ago
$200
Roundtrip
found 15 hours ago
Select United flight, departing Tue, May 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $200 found 15 hours ago
American Airlines
Tue, May 26 - Wed, Jun 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 15 hours ago
$200
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Tue, May 26 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jun 3, priced at $200 found 15 hours ago
United
Thu, Jun 11 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
PAH
Barkley Regional
$294 Roundtrip, found 11 hours ago
$294
Roundtrip
found 11 hours ago
Select United flight, departing Thu, Jun 11 from Hartsfield-Jackson Atlanta Intl. to Barkley Regional, returning Tue, Jun 16, priced at $294 found 11 hours ago
Frontier Airlines
Fri, May 8 - Wed, May 20
BDL
Bradley Intl.
STL
Lambert-St. Louis Intl.
$307 Roundtrip, found 4 days ago
$307
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Fri, May 8 from Bradley Intl. to Lambert-St. Louis Intl., returning Wed, May 20, priced at $307 found 4 days ago
United
Wed, Jun 10 - Tue, Jun 16
BDL
Bradley Intl.
PAH
Barkley Regional
$348 Roundtrip, found 2 hours ago
$348
Roundtrip
found 2 hours ago
Select United flight, departing Wed, Jun 10 from Bradley Intl. to Barkley Regional, returning Tue, Jun 16, priced at $348 found 2 hours ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in June, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Veterans Airport of Southern Illinois Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$68

Last Minute Hotel Deals in Southern Illinois

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,019 reviews)
Great.

Reviewed on Apr 13, 2026

Get rates
Drury Inn & Suites St. Louis Fairview Heights
Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,006 reviews)
Breakfast was average, room was clean, a little tired. parking was good. Nothing special but served its purpose

Reviewed on Apr 12, 2026

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Best Western Delta Inn
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,003 reviews)
Best hotel that I have stayed at in a long time

Reviewed on Apr 12, 2026

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Drury Inn & Suites St. Louis O'Fallon, IL
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,675 reviews)
Great breakfast

Reviewed on Apr 13, 2026

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Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,004 reviews)
The dead bolt didn’t work and we didn’t dare touch anything. Luckily we just needed to sleep so was a quick stay. If it were painted and had new hallway it would make a world of difference. Property is across from a pool and ice rink for local college teams, they should invest some money and capitalize ...

Reviewed on Apr 10, 2026

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Super 8 by Wyndham O'Fallon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,037 reviews)
Staff was nice.

Reviewed on Apr 13, 2026

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Comfort Suites Mount Vernon
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,005 reviews)
Mold visible, towel in room was dirt stained. It wasn’t bad for the price but looking at it online than seeing it in person was super misleading.

Reviewed on Apr 13, 2026

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Baymont by Wyndham Effingham
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,007 reviews)
Plenty of shops near by, rooms mostly clean, bathrooms very small, shower head older model, plenty of security cameras.

Reviewed on Apr 13, 2026

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Quality Inn O'Fallon IL - St. Louis
See all 1,165 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.