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Southern Illinois

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Southern Illinois Flights as Low as $56

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Wed, May 13 - Wed, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$56 Roundtrip, just found
$56
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, May 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $56 just found
Frontier Airlines
Thu, May 14 - Sat, May 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$68 Roundtrip, found 9 hours ago
$68
Roundtrip
found 9 hours ago
Select Frontier Airlines flight, departing Thu, May 14 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $68 found 9 hours ago
Frontier Airlines
Sat, May 30 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 6 hours ago
$84
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Sat, May 30 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $84 found 6 hours ago
Frontier Airlines
Sat, May 16 - Sat, May 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$90 Roundtrip, found 1 day ago
$90
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, May 16 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $90 found 1 day ago
Frontier Airlines
Fri, May 15 - Wed, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$92 Roundtrip, found 2 days ago
$92
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, May 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $92 found 2 days ago
Frontier Airlines
Tue, May 19 - Wed, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$96 Roundtrip, found 2 days ago
$96
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Tue, May 19 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $96 found 2 days ago
Frontier Airlines
Fri, May 15 - Sat, May 30
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$98 Roundtrip, found 2 days ago
$98
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, May 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, May 30, priced at $98 found 2 days ago
Frontier Airlines
Sun, Apr 26 - Mon, May 4
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$162 Roundtrip, found 19 hours ago
$162
Roundtrip
found 19 hours ago
Select Frontier Airlines flight, departing Sun, Apr 26 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Mon, May 4, priced at $162 found 19 hours ago
Delta
Wed, May 13 - Wed, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$180 Roundtrip, just found
$180
Roundtrip
just found
Select Delta flight, departing Wed, May 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $180 just found
United
Tue, Jun 2 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 22 hours ago
$200
Roundtrip
found 22 hours ago
Select United flight, departing Tue, Jun 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Jun 16, priced at $200 found 22 hours ago
American Airlines
Wed, May 13 - Wed, May 27
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, just found
$200
Roundtrip
just found
Select American Airlines flight, departing Wed, May 13 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, May 27, priced at $200 just found
Bargain Flight
Tue, Jun 23 - Tue, Jun 30
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$212 Roundtrip, found 7 hours ago
$212
Roundtrip
found 7 hours ago
Select Bargain Flight flight, departing Tue, Jun 23 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Tue, Jun 30, priced at $212 found 7 hours ago
United
Thu, Jun 11 - Tue, Jun 16
ATL
Hartsfield-Jackson Atlanta Intl.
PAH
Barkley Regional
$294 Roundtrip, just found
$294
Roundtrip
just found
Select United flight, departing Thu, Jun 11 from Hartsfield-Jackson Atlanta Intl. to Barkley Regional, returning Tue, Jun 16, priced at $294 just found
United
Fri, May 1 - Thu, May 7
DCA
Ronald Reagan Washington National
PAH
Barkley Regional
$314 Roundtrip, found 1 day ago
$314
Roundtrip
found 1 day ago
Select United flight, departing Fri, May 1 from Ronald Reagan Washington National to Barkley Regional, returning Thu, May 7, priced at $314 found 1 day ago
Bargain Flight
Thu, Jun 11 - Tue, Jun 23
BWI
Baltimore Washington Intl. Thurgood Marshall
PAH
Barkley Regional
$494 Roundtrip, found 1 day ago
$494
Roundtrip
found 1 day ago
Select Bargain Flight flight, departing Thu, Jun 11 from Baltimore Washington Intl. Thurgood Marshall to Barkley Regional, returning Tue, Jun 23, priced at $494 found 1 day ago
American Airlines
Sat, Jul 11 - Tue, Jul 14
BWI
Baltimore Washington Intl. Thurgood Marshall
CGI
Cape Girardeau Municipal
$508 Roundtrip, found 1 day ago
$508
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 11 from Baltimore Washington Intl. Thurgood Marshall to Cape Girardeau Municipal, returning Tue, Jul 14, priced at $508 found 1 day ago

Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Veterans Airport of Southern Illinois Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $56, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $56 right now, why wait?

Southern Illinois Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$98

Last Minute Hotel Deals in Southern Illinois

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,017 reviews)
Arrived late and they were very accommodating and the room was clean and comfortable.

Reviewed on Apr 11, 2026

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Drury Inn & Suites St. Louis Fairview Heights
Best Western Delta Inn

Best Western Delta Inn

2.5 out of 5
1509 Hampton Dr Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (1,003 reviews)
Nice clean hotel. Breakfast variety limited

Reviewed on Apr 10, 2026

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Best Western Delta Inn
Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

3 out of 5
1118 Central Park Drive O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,002 reviews)
Very nice and clean

Reviewed on Apr 10, 2026

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Drury Inn & Suites St. Louis O'Fallon, IL
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,672 reviews)
Good hotel. The air conditioning didn't work overnight and only started working when we were ready to leave the next morning but they were kind to provide us a fan.

Reviewed on Apr 12, 2026

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Drury Plaza Hotel Mt. Vernon
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

2.5 out of 5
404 South 44th Street Mount Vernon IL
Book a stay at this business-friendly hotel in Mount Vernon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,033 reviews)
Staff was great, room was clean, parking was good and breakfast was perfect.

Reviewed on Apr 11, 2026

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Comfort Suites Mount Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.8/10 (1,004 reviews)
The dead bolt didn’t work and we didn’t dare touch anything. Luckily we just needed to sleep so was a quick stay. If it were painted and had new hallway it would make a world of difference. Property is across from a pool and ice rink for local college teams, they should invest some money and capitalize ...

Reviewed on Apr 10, 2026

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Super 8 by Wyndham O'Fallon
Baymont by Wyndham Effingham

Baymont by Wyndham Effingham

2.5 out of 5
1811 W Fayette Avenue Effingham IL
Book a stay at this business-friendly hotel in Effingham. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,004 reviews)
Staff was super friendly. We left our pillow on the bed. I didnt notice it until we needed it the next night.. I called they said they had it at front desk. We stopped on our way back through the area... Breakfast was very good variety of food hot and cold. Room was clean , bed was comfortable.

Reviewed on Apr 11, 2026

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Baymont by Wyndham Effingham
Quality Inn O'Fallon IL - St. Louis

Quality Inn O'Fallon IL - St. Louis

3 out of 5
1409 W US 50 O'Fallon IL
Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (1,005 reviews)
Very good staff

Reviewed on Apr 5, 2026

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Quality Inn O'Fallon IL - St. Louis
See all 1,165 properties in Southern Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.