Search Cheap Flights to
Florence Regional

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Cheap Flights to Florence Regional

Fall in love at first flight with your vacation to Florence Regional by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence Regional on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence Regional, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence Regional

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence Regional with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Florence Regional?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence Regional are in , but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence Regional?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find  to choose from for your flight to Florence Regional.

What airport is best to fly into Florence Regional?

When you’re planning your trip to Florence Regional, convenience is the name of the game. Luckily, Florence Regional Myrtle Beach Intl. Airport is nearby so you can deplane and get going on checking off everything on your Florence Regional must-do list.

How much are flights to Florence Regional?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence Regional on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as , you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence Regional?

The trick to saving a stack of cash on your flight to Florence Regional? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as  right now, why wait?

Florence Regional Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO

Last Minute Hotel Deals in Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,000 reviews)
Everything was great. The room were clean and staff was courteous.

Reviewed on Nov 2, 2025

Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St, Florence, SC
Stay at this 3-star spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (592 reviews)
I stayed at Hotel Florence last year, and had the same issue then as I had this year: My room was not cleaned. I stayed two nights, and had to ask for fresh towels at the front desk that evening (because of course cleaning crew were no longer on site and no other services were available). The hotel ...

Reviewed on Oct 23, 2025

Hotel Florence, Tapestry Collection by Hilton
Rodeway Inn Florence Downtown

Rodeway Inn Florence Downtown

2 out of 5
415 S. IRBY ST, Florence, SC
Stay at this hotel in Florence. Enjoy free WiFi. Popular attractions Drs Bruce and Lee Foundation Library and Florence Museum are located nearby.
6/10 (2 reviews)
Good

Reviewed on Oct 3, 2025

Rodeway Inn Florence Downtown
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,176 reviews)
Receiving a print-out at check-in of the password, the hotel amenities, and information on nearby restaurants and local activities. A nice room, a comfortable bed and a good buffet breakfast. It's easy to see the property from the exit, but I do wish there had been some kind of signage where the ...

Reviewed on Nov 5, 2025

Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,418 reviews)
Easy parking and clean room. Old school style motel.

Reviewed on Nov 5, 2025

Howard Johnson by Wyndham Florence
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,705 reviews)
Room clean, staff polite and breakfast had many options.

Reviewed on Nov 4, 2025

La Quinta Inn & Suites by Wyndham Florence
Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95

2.5 out of 5
1735 Stokes Road, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (768 reviews)
The room was spotless, check-in was courteous wonderful breakfast great hotel.

Reviewed on Nov 5, 2025

Hampton Inn & Suites Florence-North-I-95
Best Western Inn

Best Western Inn

2.5 out of 5
1808 W Lucas Street, Florence, SC
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Dr. ...
7.6/10 Good! (1,001 reviews)
The room was clean and the bed was comfortable. The room could use a refresh with some new carpet, toilet, etc. We felt safe at this hotel compared to others we’ve stayed at in the Florence area. The morning staff person at check out was pleasant. Check in staff person was all business. Breakfast ...

Reviewed on Nov 6, 2025

Best Western Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.