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Florence Regional

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Florence Regional Flights as Low as $397

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Sat, Aug 30 - Tue, Sep 2
TPA
Tampa Intl.
FLO
Florence Regional
$397 Roundtrip, found 4 days ago
$397
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Aug 30 from Tampa Intl. to Florence Regional, returning Tue, Sep 2, priced at $397 found 4 days ago
American Airlines
Wed, Aug 27 - Sat, Aug 30
TPA
Tampa Intl.
FLO
Florence Regional
$415 Roundtrip, found 5 days ago
$415
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 27 from Tampa Intl. to Florence Regional, returning Sat, Aug 30, priced at $415 found 5 days ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
TTN
Mercer
FLO
Florence Regional
$418 Roundtrip, found 23 hours ago
$418
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Oct 8 from Mercer to Florence Regional, returning Mon, Oct 13, priced at $418 found 23 hours ago
American Airlines
Wed, Aug 27 - Sat, Aug 30
TPA
Tampa Intl.
FLO
Florence Regional
$435 Roundtrip, found 5 days ago
$435
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 27 from Tampa Intl. to Florence Regional, returning Sat, Aug 30, priced at $435 found 5 days ago
American Airlines
Sat, Aug 30 - Tue, Sep 2
TPA
Tampa Intl.
FLO
Florence Regional
$457 Roundtrip, found 4 days ago
$457
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Aug 30 from Tampa Intl. to Florence Regional, returning Tue, Sep 2, priced at $457 found 4 days ago
American Airlines
Sat, Oct 11 - Tue, Oct 14
PHL
Philadelphia Intl.
FLO
Florence Regional
$459 Roundtrip, found 23 hours ago
$459
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Oct 11 from Philadelphia Intl. to Florence Regional, returning Tue, Oct 14, priced at $459 found 23 hours ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
TTN
Mercer
FLO
Florence Regional
$464 Roundtrip, found 5 days ago
$464
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Oct 8 from Mercer to Florence Regional, returning Mon, Oct 13, priced at $464 found 5 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$469 Roundtrip, found 23 hours ago
$469
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $469 found 23 hours ago
American Airlines
Sat, Aug 16 - Sat, Aug 23
TPA
Tampa Intl.
FLO
Florence Regional
$473 Roundtrip, found 17 hours ago
$473
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Sat, Aug 16 from Tampa Intl. to Florence Regional, returning Sat, Aug 23, priced at $473 found 17 hours ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
TTN
Mercer
FLO
Florence Regional
$474 Roundtrip, found 23 hours ago
$474
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Oct 8 from Mercer to Florence Regional, returning Mon, Oct 13, priced at $474 found 23 hours ago
American Airlines
Tue, Aug 19 - Sat, Aug 23
TPA
Tampa Intl.
FLO
Florence Regional
$475 Roundtrip, found 17 hours ago
$475
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Aug 19 from Tampa Intl. to Florence Regional, returning Sat, Aug 23, priced at $475 found 17 hours ago
American Airlines
Wed, Aug 27 - Sat, Aug 30
TPA
Tampa Intl.
FLO
Florence Regional
$477 Roundtrip, found 5 days ago
$477
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Aug 27 from Tampa Intl. to Florence Regional, returning Sat, Aug 30, priced at $477 found 5 days ago
American Airlines
Fri, Aug 15 - Sat, Aug 16
TPA
Tampa Intl.
FLO
Florence Regional
$478 Roundtrip, found 17 hours ago
$478
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Fri, Aug 15 from Tampa Intl. to Florence Regional, returning Sat, Aug 16, priced at $478 found 17 hours ago
American Airlines
Tue, Aug 19 - Sun, Aug 24
TPA
Tampa Intl.
FLO
Florence Regional
$480 Roundtrip, found 17 hours ago
$480
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Tue, Aug 19 from Tampa Intl. to Florence Regional, returning Sun, Aug 24, priced at $480 found 17 hours ago
American Airlines
Thu, Aug 14 - Thu, Aug 21
TPA
Tampa Intl.
FLO
Florence Regional
$484 Roundtrip, found 17 hours ago
$484
Roundtrip
found 17 hours ago
Select American Airlines flight, departing Thu, Aug 14 from Tampa Intl. to Florence Regional, returning Thu, Aug 21, priced at $484 found 17 hours ago
American Airlines
Fri, Oct 10 - Sun, Oct 12
PHL
Philadelphia Intl.
FLO
Florence Regional
$489 Roundtrip, found 23 hours ago
$489
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Oct 10 from Philadelphia Intl. to Florence Regional, returning Sun, Oct 12, priced at $489 found 23 hours ago

Cheap Flights to Florence Regional

Fall in love at first flight with your vacation to Florence Regional by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Florence Regional on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Florence Regional, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Florence Regional

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Florence Regional with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Florence Regional?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Florence Regional are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Florence Regional?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Florence Regional.

What airport is best to fly into Florence Regional?

When you’re planning your trip to Florence Regional, convenience is the name of the game. Luckily, Florence Regional Myrtle Beach Intl. Airport is nearby so you can deplane and get going on checking off everything on your Florence Regional must-do list.

How much are flights to Florence Regional?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Florence Regional on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $397, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Florence Regional?

The trick to saving a stack of cash on your flight to Florence Regional? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $397 right now, why wait?

Florence Regional Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Airlines serving
American Airlines
Number of airlines serving
1
Roundtrip price
$410
Popular airline
American Airlines

Last Minute Hotel Deals in Florence Regional

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,002 reviews)
"Bed not comfy, very soft."

Reviewed on Aug 7, 2025

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Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton

Hotel Florence, Tapestry Collection by Hilton

3 out of 5
126 W Evans St, Florence, SC
Stay at this 3-star spa hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
8.8/10 Excellent! (578 reviews)
"Nice breakfast"

Reviewed on Aug 6, 2025

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Hotel Florence, Tapestry Collection by Hilton
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,120 reviews)
"The only issue I would say is the beds are a little hard but it was a nice stay. Breakfast is small but okay for a quick over night trip!"

Reviewed on Aug 10, 2025

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Park Inn by Radisson Florence, SC
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,337 reviews)
"i really like the room and bath, newly renovated, great water pressure. The lobby needs partitioning for food service. Coffee weak. departed before breakfast"

Reviewed on Aug 10, 2025

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Howard Johnson by Wyndham Florence
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,674 reviews)
"Room was clean bed was comfortable the plug for the tub did not work and when I went for breakfast the eggs and sausages were cold"

Reviewed on Aug 9, 2025

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La Quinta Inn & Suites by Wyndham Florence
Best Western Inn

Best Western Inn

2.5 out of 5
1808 W Lucas Street, Florence, SC
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Dr. ...
7.4/10 Good! (1,000 reviews)
"Convenient location for a quick stop."

Reviewed on Aug 4, 2025

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Best Western Inn
Days Inn by Wyndham Florence/I-95 North

Days Inn by Wyndham Florence/I-95 North

2 out of 5
2111 West Lucas St/I-95, I-95 & Hwy 52 Exit 164, Florence, SC
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,002 reviews)
"Overall a good stay . Breakfast . Clean sheets"

Reviewed on Aug 11, 2025

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Days Inn by Wyndham Florence/I-95 North
Super 8 by Wyndham Florence

Super 8 by Wyndham Florence

2 out of 5
1832 1/2 Lucas Street, I95 Exit 164, Florence, SC
Stay at this motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
6.8/10 (1,000 reviews)
"Can’t beat the price. Honestly the room was clean. The comforter has see better days. There also was a lady sitting on the walkway playing music which was a nice wake up call lmao."

Reviewed on Aug 4, 2025

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Super 8 by Wyndham Florence
See all 108 properties in Florence Regional
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.