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5 Star Hotels in Santa Clara

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Featured 5 Star Santa Clara Hotels

Hotel Riu Plaza Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 30 min drive from Culebra Cut
The price is $101 per night from Apr 28 to Apr 29
$101
per night
Apr 28 - Apr 29
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 3 restaurants, and a fitness center. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Riu Plaza Panama
W Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 29 min drive from Culebra Cut
The price is $178 per night from May 13 to May 14
$178
per night
May 13 - May 14
Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 2 bars/lounges, and 3 spa tubs. Our guests praise the breakfast and the pool in our reviews. ...
W Panama
JW Marriott Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 32 min drive from Culebra Cut
The price is $191 per night from May 4 to May 5
$191
per night
May 4 - May 5
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the pool and the helpful staff in our ...
JW Marriott Panama
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Waldorf Astoria Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 30 min drive from Culebra Cut
The price is $215 per night from May 3 to May 4
$215
per night
May 3 - May 4
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
Waldorf Astoria Panama
Sofitel Legend Casco Viejo, Panama City
5 out of 5
Fully refundableReserve now, pay when you stay
  • 31 min drive from Culebra Cut
The price is $292 per night from May 1 to May 2
$292
per night
May 1 - May 2
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the breakfast and the pool in our reviews. ...
Sofitel Legend Casco Viejo, Panama City
Hilton Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 30 min drive from Culebra Cut
The price is $231 per night from May 1 to May 2
$231
per night
May 1 - May 2
Stay at this 5-star luxury hotel in Panama City. Enjoy 4 restaurants, an attached winery, and a casino. Our guests praise the pool and the helpful staff in our ...
Hilton Panama
The Westin Playa Bonita Panama
5 out of 5
Fully refundableReserve now, pay when you stay
  • 34 min drive from Culebra Cut
The price is $152 per night from May 7 to May 8
$152
per night
May 7 - May 8
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and 4 restaurants. Our guests praise the pool and the helpful staff in our ...
The Westin Playa Bonita Panama
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
5 out of 5
Fully refundableReserve now, pay when you stay
  • 37 min drive from Culebra Cut
The price is $229 per night from May 24 to May 25
$229
per night
May 24 - May 25
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the breakfast and the helpful staff in our ...
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Bristol Panama, a Registry Collection Hotel
5 out of 5
Fully refundableReserve now, pay when you stay
  • 29 min drive from Culebra Cut
The price is $204 per night from May 12 to May 13
$204
per night
May 12 - May 13
Stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the breakfast and the restaurant in ...
Bristol Panama, a Registry Collection Hotel
Villa Palma Boutique Hotel
5 out of 5
  • 31 min drive from Culebra Cut
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a rooftop terrace, and breakfast. Our guests praise the breakfast and the helpful staff in ...
Villa Palma Boutique Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

5-Star Hotel in Santa Clara

It’s time. No more meh motels and so-so stays. This vacation it’s all about living it up, and that starts with a great hotel. You want first-class service and award-winning restaurants. Well, let us introduce you to a 5-star hotel in Santa Clara.

So nice you’ll blink twice

What makes a hotel worthy of supreme star-age? For starters, the service has to be top-notch and personalized. These hotels often have 24-hour room service, a welcome gift upon your arrival, and help you with your bags—even if you travel light.

Are they nicer? Heck yeah, they are! Most 5-star hotels have jaw-dropping aesthetics that give an authentic feel of class. And we’re not talking about that faux-gold soap dish your Aunt Tilda puts out for the guests—it’s the real deal.

Stars in your eyes

Are 5-stars hotels worth it? If you like the finer things in life, then yes, they sure are. But we also know you’re the type that likes to get your caviar on a fish stick budget. We’re right there with you, and that is why we make it easy to find the best 5-star hotel in Santa Clara for you. Sort by:

  • Price: Want to live large, but keep that budget balanced? We got you. We have 5-star hotels starting at $101.

  • Amenities: Santa Clara skyline view? Maybe a heated indoor pool? Looking for a Michelin-star restaurant? Search for the hotels that have the amenities you desire.

  • Hotwire Hot Rate: We’ll tell you the name of the hotel after you book, and you might just save a ton.

When you’re looking for the top 5-star hotels in Santa Clara—but don’t want to pay top dollar—let us help you out. You can get that posh palace of your dreams, and have money left to take on Santa Clara your way.