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Southeast Missouri

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Southeast Missouri Flights as Low as $140

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Spirit Airlines
Mon, Aug 25 - Thu, Sep 4
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 1 day ago
$140
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Aug 25 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $140 found 1 day ago
Spirit Airlines
Thu, Sep 18 - Sun, Sep 21
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$156 Roundtrip, found 19 hours ago
$156
Roundtrip
found 19 hours ago
Select Spirit Airlines flight, departing Thu, Sep 18 from LaGuardia to Lambert-St. Louis Intl., returning Sun, Sep 21, priced at $156 found 19 hours ago
Spirit Airlines
Sun, Aug 17 - Mon, Aug 18
PHL
Philadelphia Intl.
STL
Lambert-St. Louis Intl.
$169 Roundtrip, found 4 days ago
$169
Roundtrip
found 4 days ago
Select Spirit Airlines flight, departing Sun, Aug 17 from Philadelphia Intl. to Lambert-St. Louis Intl., returning Mon, Aug 18, priced at $169 found 4 days ago
Delta
Sat, Sep 27 - Sat, Sep 27
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$174 Roundtrip, found 23 hours ago
$174
Roundtrip
found 23 hours ago
Select Delta flight, departing Sat, Sep 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Sep 27, priced at $174 found 23 hours ago
United
Wed, Aug 27 - Thu, Sep 4
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 20 hours ago
$176
Roundtrip
found 20 hours ago
Select United flight, departing Wed, Aug 27 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $176 found 20 hours ago
Spirit Airlines
Thu, Sep 18 - Sun, Sep 21
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$176 Roundtrip, found 19 hours ago
$176
Roundtrip
found 19 hours ago
Select Spirit Airlines flight, departing Thu, Sep 18 from LaGuardia to Lambert-St. Louis Intl., returning Sun, Sep 21, priced at $176 found 19 hours ago
Delta
Tue, Aug 26 - Tue, Sep 2
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$179 Roundtrip, found 3 days ago
$179
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Aug 26 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Sep 2, priced at $179 found 3 days ago
American Airlines
Wed, Aug 27 - Wed, Sep 3
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$179 Roundtrip, found 4 days ago
$179
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Wed, Sep 3, priced at $179 found 4 days ago
United
Thu, Sep 25 - Tue, Sep 30
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$181 Roundtrip, found 23 hours ago
$181
Roundtrip
found 23 hours ago
Select United flight, departing Thu, Sep 25 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Sep 30, priced at $181 found 23 hours ago
Spirit Airlines
Fri, Aug 22 - Thu, Aug 28
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$182 Roundtrip, found 5 days ago
$182
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Fri, Aug 22 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Thu, Aug 28, priced at $182 found 5 days ago
United
Wed, Aug 27 - Wed, Sep 3
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$188 Roundtrip, found 4 days ago
$188
Roundtrip
found 4 days ago
Select United flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Wed, Sep 3, priced at $188 found 4 days ago
Frontier Airlines
Sat, Aug 23 - Mon, Aug 25
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$222 Roundtrip, found 5 days ago
$222
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Sat, Aug 23 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Mon, Aug 25, priced at $222 found 5 days ago
Hawaiian Airlines
Mon, Sep 29 - Tue, Sep 30
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$227 Roundtrip, found 23 hours ago
$227
Roundtrip
found 23 hours ago
Select Hawaiian Airlines flight, departing Mon, Sep 29 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Sep 30, priced at $227 found 23 hours ago
Frontier Airlines
Thu, Oct 16 - Fri, Oct 17
TTN
Mercer
STL
Lambert-St. Louis Intl.
$228 Roundtrip, found 2 days ago
$228
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Oct 16 from Mercer to Lambert-St. Louis Intl., returning Fri, Oct 17, priced at $228 found 2 days ago
Alaska Airlines
Wed, Aug 27 - Thu, Sep 4
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$231 Roundtrip, found 11 hours ago
$231
Roundtrip
found 11 hours ago
Select Alaska Airlines flight, departing Wed, Aug 27 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Thu, Sep 4, priced at $231 found 11 hours ago
Bargain Flight
Sun, Aug 31 - Sat, Sep 6
PAE
Seattle Paine Field Intl. Airport
STL
Lambert-St. Louis Intl.
$536 Roundtrip, found 3 days ago
$536
Roundtrip
found 3 days ago
Select Bargain Flight flight, departing Sun, Aug 31 from Seattle Paine Field Intl. Airport to Lambert-St. Louis Intl., returning Sat, Sep 6, priced at $536 found 3 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 15 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $140, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $140 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$72

Last Minute Hotel Deals in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,022 reviews)
"I was very impressed with this motel. Very clean and the staff was very friendly and helpful. The breakfast was delicious!!!"

Reviewed on Jul 28, 2025

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Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (365 reviews)
Great Economical Place to Stay
"It was a great place to stay. Even though a casino is attached to the hotel, it seemed like we were in a nice secluded area of Cape Girardeau. Everything was like new and very nice. Even had a Starbucks so we were able to get a refreshment before we got back on the road. The only down side was that ..."

Reviewed on Jul 29, 2025

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The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,016 reviews)
5 stars
"Hotel was extremely nice and comfortable. Unfortunately my family was unable to take advantage of the drinks and snacks in the lobby due to several youth volleyball teams also staying at the hotel. They took over the lobby and pool area and were so loud we couldn’t hear the hotel staff checking us ..."

Reviewed on Jul 24, 2025

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Drury Plaza Hotel Cape Girardeau Conference Center
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,002 reviews)
"The little self service store in the lobby is a nice touch. Pepsi supplies and runs it."

Reviewed on Jul 26, 2025

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Motel 6 Poplar Bluff, MO
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,009 reviews)
Super Facility Near The Medical Center!
"I have stayed at this Hotel several times when I have had early morning reporting times at St. Francis Medical Center. Each time it has been great. Friendly staff quiet atmosphere and great rooms with comfortable furnishings."

Reviewed on Jul 29, 2025

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Pear Tree Inn Cape Girardeau Near the Medical Center
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St, Caruthersville, MO
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (394 reviews)
"Quiet"

Reviewed on Jul 26, 2025

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The Farmstead Hotel
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (585 reviews)
"Hotel was clean. Large dining area. Was able to accommodate our large group"

Reviewed on Jul 14, 2025

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La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 out of 5
120 S Interstate Drive, Sikeston, MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.2/10 Very Good! (1,010 reviews)
"The area was clean and in a good area older room but had been renovated comfy bed and the a/c worked really well"

Reviewed on Jul 28, 2025

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Best Western Plus Sikeston
See all 588 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.