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Southeast Missouri

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Southeast Missouri Flights as Low as $58

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Mon, Aug 24 - Wed, Sep 9
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$58 Roundtrip, found 1 hour ago
$58
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Mon, Aug 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 9, priced at $58 found 1 hour ago
Frontier Airlines
Tue, Jul 28 - Sun, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$66 Roundtrip, found 1 hour ago
$66
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Aug 2, priced at $66 found 1 hour ago
Frontier Airlines
Fri, Jul 31 - Mon, Aug 3
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$78 Roundtrip, found 3 hours ago
$78
Roundtrip
found 3 hours ago
Select Frontier Airlines flight, departing Fri, Jul 31 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Aug 3, priced at $78 found 3 hours ago
Delta
Tue, Jul 28 - Sat, Aug 8
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$87 Roundtrip, found 3 days ago
$87
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Aug 8, priced at $87 found 3 days ago
Frontier Airlines
Thu, Aug 6 - Fri, Aug 7
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$87 Roundtrip, found 1 day ago
$87
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Aug 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Aug 7, priced at $87 found 1 day ago
Frontier Airlines
Fri, Jul 24 - Fri, Jul 24
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$88 Roundtrip, found 5 days ago
$88
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Fri, Jul 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Jul 24, priced at $88 found 5 days ago
Delta
Tue, Jul 28 - Sun, Aug 2
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$97 Roundtrip, found 1 hour ago
$97
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Jul 28 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Aug 2, priced at $97 found 1 hour ago
Delta
Mon, Aug 24 - Wed, Sep 9
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$99 Roundtrip, found 1 hour ago
$99
Roundtrip
found 1 hour ago
Select Delta flight, departing Mon, Aug 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 9, priced at $99 found 1 hour ago
Frontier Airlines
Wed, Jul 22 - Wed, Jul 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$101 Roundtrip, found 5 days ago
$101
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Wed, Jul 22 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Jul 22, priced at $101 found 5 days ago
Frontier Airlines
Tue, Jul 21 - Fri, Jul 24
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$105 Roundtrip, found 5 days ago
$105
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Tue, Jul 21 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Jul 24, priced at $105 found 5 days ago
Delta
Tue, Aug 4 - Tue, Aug 4
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$114 Roundtrip, found 1 hour ago
$114
Roundtrip
found 1 hour ago
Select Delta flight, departing Tue, Aug 4 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Tue, Aug 4, priced at $114 found 1 hour ago
American Airlines
Mon, Aug 24 - Wed, Sep 9
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$163 Roundtrip, found 1 hour ago
$163
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Mon, Aug 24 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Sep 9, priced at $163 found 1 hour ago
Bargain Flight
Wed, Jul 29 - Wed, Aug 5
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$235 Roundtrip, found 1 hour ago
$235
Roundtrip
found 1 hour ago
Select Bargain Flight flight, departing Wed, Jul 29 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Wed, Aug 5, priced at $235 found 1 hour ago
Bargain Flight
Tue, Jul 28 - Wed, Jul 29
BWI
Baltimore Washington Intl. Thurgood Marshall
STL
Lambert-St. Louis Intl.
$237 Roundtrip, found 10 hours ago
$237
Roundtrip
found 10 hours ago
Select Bargain Flight flight, departing Tue, Jul 28 from Baltimore Washington Intl. Thurgood Marshall to Lambert-St. Louis Intl., returning Wed, Jul 29, priced at $237 found 10 hours ago
Frontier Airlines
Tue, Aug 11 - Tue, Aug 25
BOS
Logan Intl.
STL
Lambert-St. Louis Intl.
$253 Roundtrip, just found
$253
Roundtrip
just found
Select Frontier Airlines flight, departing Tue, Aug 11 from Logan Intl. to Lambert-St. Louis Intl., returning Tue, Aug 25, priced at $253 just found
American Airlines
Tue, Jul 14 - Wed, Jul 15
BWI
Baltimore Washington Intl. Thurgood Marshall
CGI
Cape Girardeau Municipal
$621 Roundtrip, found 3 days ago
$621
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jul 14 from Baltimore Washington Intl. Thurgood Marshall to Cape Girardeau Municipal, returning Wed, Jul 15, priced at $621 found 3 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 14 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $58, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $58 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Veterans Airport of Southern Illinois
Destination airport IATA code
MWA
Roundtrip price
$486

Last Minute Hotel Deals in Southeast Missouri

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (1,014 reviews)
"Drury Hotels are great. Love the amenities, service, and nice rooms."

Reviewed on Jul 7, 2026

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Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,013 reviews)
"This is an Asian Indian owned property. They typically do not keep up their properties well"

Reviewed on Jul 7, 2026

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Baymont Inn and Suites by Wyndham Farmington, MO
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,007 reviews)
"We had a very good visit here. The staff was so friendly and helpful. Our room was spacious and clean. The A/C was so cool in the room."

Reviewed on Jul 7, 2026

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Drury Inn & Suites Sikeston, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Century Casino & Hotel Cape ...
9.4/10 Exceptional! (620 reviews)
"The bed was super comfortable as I really didn't want to leave. Atmosphere was pleasant. Shower was a little slow and I despise the card entry on the elevator. So inconvenient for me."

Reviewed on Jul 7, 2026

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The Riverview
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,002 reviews)
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on Jul 4, 2026

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Days Inn and Suites by Wyndham Sikeston
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3 out of 5
1001 Veterans Blvd Festus MO
Book a stay at this business-friendly hotel in Festus. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,005 reviews)
"Very good breakfast choices!"

Reviewed on Jul 7, 2026

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La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

2 out of 5
7555 State Hwy Y French Village MO
Stay at this cabin in French Village. Enjoy free parking, patios, and climate control.
9.8/10 Exceptional! (82 reviews)
"Me and my wife loved it !! Definitely going back !!"

Reviewed on Jul 6, 2026

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Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,008 reviews)
"Unexpectedly good breakfast buffet, free popcorn and soda at night, clean, welcoming, safe all around."

Reviewed on Jul 6, 2026

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Pear Tree Inn Cape Girardeau West
See all 676 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.