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Southeast Missouri

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Southeast Missouri Flights as Low as $188

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, May 1 - Wed, May 14
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$188 Roundtrip, found 6 days ago
$188
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Thu, May 1 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Wed, May 14, priced at $188 found 6 days ago
Frontier Airlines
Wed, May 14 - Fri, May 16
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$190 Roundtrip, found 6 hours ago
$190
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Wed, May 14 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Fri, May 16, priced at $190 found 6 hours ago
Frontier Airlines
Sun, May 25 - Thu, May 29
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 20 hours ago
$191
Roundtrip
found 20 hours ago
Select Frontier Airlines flight, departing Sun, May 25 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Thu, May 29, priced at $191 found 20 hours ago
Frontier Airlines
Wed, May 14 - Wed, May 21
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$200 Roundtrip, found 6 hours ago
$200
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Wed, May 14 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $200 found 6 hours ago
Frontier Airlines
Mon, May 19 - Wed, May 21
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$202 Roundtrip, found 6 hours ago
$202
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Mon, May 19 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $202 found 6 hours ago
American Airlines
Fri, May 30 - Mon, Jun 9
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$208 Roundtrip, found 14 hours ago
$208
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, May 30 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Mon, Jun 9, priced at $208 found 14 hours ago
Frontier Airlines
Wed, May 14 - Mon, May 19
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$210 Roundtrip, found 6 hours ago
$210
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Wed, May 14 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Mon, May 19, priced at $210 found 6 hours ago
Frontier Airlines
Fri, May 16 - Fri, May 16
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$212 Roundtrip, found 6 hours ago
$212
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Fri, May 16 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Fri, May 16, priced at $212 found 6 hours ago
Delta
Sun, Aug 31 - Sun, Aug 31
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 4 days ago
$217
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Aug 31 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Sun, Aug 31, priced at $217 found 4 days ago
American Airlines
Fri, May 30 - Mon, Jun 9
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 14 hours ago
$217
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Fri, May 30 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Mon, Jun 9, priced at $217 found 14 hours ago
Frontier Airlines
Wed, May 14 - Sat, May 17
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$220 Roundtrip, found 6 hours ago
$220
Roundtrip
found 6 hours ago
Select Frontier Airlines flight, departing Wed, May 14 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Sat, May 17, priced at $220 found 6 hours ago
Frontier Airlines
Thu, May 15 - Wed, May 21
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$221 Roundtrip, found 21 hours ago
$221
Roundtrip
found 21 hours ago
Select Frontier Airlines flight, departing Thu, May 15 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Wed, May 21, priced at $221 found 21 hours ago
United
Fri, May 30 - Mon, Jun 9
DCA
Ronald Reagan Washington National
STL
Lambert-St. Louis Intl.
$241 Roundtrip, found 14 hours ago
$241
Roundtrip
found 14 hours ago
Select United flight, departing Fri, May 30 from Ronald Reagan Washington National to Lambert-St. Louis Intl., returning Mon, Jun 9, priced at $241 found 14 hours ago
American Airlines
Tue, Jun 10 - Wed, Jun 18
LAX
Los Angeles Intl.
CGI
Cape Girardeau Municipal
$438 Roundtrip, found 5 days ago
$438
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, Jun 10 from Los Angeles Intl. to Cape Girardeau Municipal, returning Wed, Jun 18, priced at $438 found 5 days ago
Alaska Airlines
Sat, May 24 - Wed, May 28
ONT
Los Angeles - Ontario Intl.
STL
Lambert-St. Louis Intl.
$441 Roundtrip, found 1 day ago
$441
Roundtrip
found 1 day ago
Select Alaska Airlines flight, departing Sat, May 24 from Los Angeles - Ontario Intl. to Lambert-St. Louis Intl., returning Wed, May 28, priced at $441 found 1 day ago
Hawaiian Airlines
Thu, May 1 - Tue, May 13
LAX
Los Angeles Intl.
STL
Lambert-St. Louis Intl.
$514 Roundtrip, found 6 days ago
$514
Roundtrip
found 6 days ago
Select Hawaiian Airlines flight, departing Thu, May 1 from Los Angeles Intl. to Lambert-St. Louis Intl., returning Tue, May 13, priced at $514 found 6 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in May, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $188, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $188 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$188

Last Minute Hotel Deals in Southeast Missouri

The Riverview
The Riverview
3.5 out of 5
777 Main St, Cape Girardeau, MO
The price is $121 per night from May 5 to May 6
$121
includes taxes & fees
May 5 - May 6
Stay at this 3.5-star hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront ...
9.2/10 Wonderful! (240 reviews)
Great value and close to main street
"Overall a great clean room, very comfortable. Rooms do not include a coffee pot. Minor issue but would greatly improve the stay. Aside from that, the hotel lobby shares the casino lobby so the smoke smell is strong in the lobby. You can’t smell it in the hotel rooms though which was great. I would ..."

Reviewed on Apr 27, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
The price is $112 per night from May 4 to May 5
$112
includes taxes & fees
May 4 - May 5
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,001 reviews)
"It was perfect for our stay."

Reviewed on Apr 26, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
The price is $66 per night from May 6 to May 7
$66
includes taxes & fees
May 6 - May 7
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (926 reviews)
"Easy to find"

Reviewed on Apr 26, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
The price is $83 per night from May 5 to May 6
$83
includes taxes & fees
May 5 - May 6
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,000 reviews)
"Great value for the price"

Reviewed on Apr 23, 2025

Motel 6 Poplar Bluff, MO
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 out of 5
2602 E Malone Avenue, Sikeston, MO
The price is $98 per night from May 4 to May 5
$98
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,000 reviews)
Quiet, solid building, no noise while sleeping day
"Quiet. Just what I needed for day time sleep."

Reviewed on Apr 28, 2025

Pear Tree Inn Sikeston
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 out of 5
3253 William Street, Cape Girardeau, MO
The price is $116 per night from May 4 to May 5
$116
includes taxes & fees
May 4 - May 5
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Return Stay💋
"I chose this hotel because I stayed 8 months ago when I daughter was scheduled for a C-section and I was so happy with the staff, location of the property and condition of the room I had to return."

Reviewed on Apr 25, 2025

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
2.5 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
The price is $86 per night from May 1 to May 2
$86
includes taxes & fees
May 1 - May 2
Book a stay at this business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (542 reviews)
"Coveniently right off the interstate. Very clean and quiet."

Reviewed on Apr 26, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
The Farmstead Hotel
The Farmstead Hotel
2.5 out of 5
778 E 3rd St, Caruthersville, MO
The price is $101 per night from May 1 to May 2
$101
includes taxes & fees
May 1 - May 2
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
"I have stayed here many times while visiting and have always felt safe. Whenever i need anything safe is always friendly and helpful"

Reviewed on Apr 24, 2025

The Farmstead Hotel
See all 563 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.