Search Cheap Flights toSoutheast Missouri
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Southeast Missouri Flights as Low as $63
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Fri, Jul 4 - Fri, Jul 4
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$63 Roundtrip, found 8 hours ago
$63
Roundtrip
found 8 hours ago
Fri, Jul 11 - Sun, Jul 13
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$70 Roundtrip, found 1 day ago
$70
Roundtrip
found 1 day ago
Thu, Jul 10 - Thu, Jul 17
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$71 Roundtrip, found 1 day ago
$71
Roundtrip
found 1 day ago
Thu, Jul 3 - Mon, Jul 7
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$73 Roundtrip, found 9 hours ago
$73
Roundtrip
found 9 hours ago
Fri, Jul 11 - Sat, Jul 12
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$79 Roundtrip, found 1 day ago
$79
Roundtrip
found 1 day ago
Thu, Jul 17 - Sun, Aug 3
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$80 Roundtrip, found 3 days ago
$80
Roundtrip
found 3 days ago
Thu, Jul 10 - Sun, Jul 13
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$82 Roundtrip, found 1 day ago
$82
Roundtrip
found 1 day ago
Mon, Jun 23 - Fri, Jun 27
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$83 Roundtrip, found 5 days ago
$83
Roundtrip
found 5 days ago
Mon, Jun 23 - Mon, Jun 30
DTW
Detroit Metropolitan Wayne County
STL
Lambert-St. Louis Intl.
$84 Roundtrip, found 5 days ago
$84
Roundtrip
found 5 days ago
Tue, Aug 26 - Tue, Aug 26
DFW
Dallas-Fort Worth Intl.
STL
Lambert-St. Louis Intl.
$134 Roundtrip, found 8 hours ago
$134
Roundtrip
found 8 hours ago
Mon, Aug 25 - Sat, Aug 30
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$154 Roundtrip, found 6 days ago
$154
Roundtrip
found 6 days ago
Sat, Aug 23 - Tue, Aug 26
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$163 Roundtrip, found 6 days ago
$163
Roundtrip
found 6 days ago
Tue, Aug 26 - Tue, Aug 26
DAL
Love Field
STL
Lambert-St. Louis Intl.
$191 Roundtrip, found 7 hours ago
$191
Roundtrip
found 7 hours ago
Tue, Nov 18 - Wed, Nov 19
LGA
LaGuardia
STL
Lambert-St. Louis Intl.
$217 Roundtrip, found 2 days ago
$217
Roundtrip
found 2 days ago
Mon, Aug 18 - Wed, Aug 27
DFW
Dallas-Fort Worth Intl.
PAH
Barkley Regional
$360 Roundtrip, found 3 days ago
$360
Roundtrip
found 3 days ago
Fri, Jul 4 - Wed, Jul 9
DTW
Detroit Metropolitan Wayne County
PAH
Barkley Regional
$415 Roundtrip, found 2 days ago
$415
Roundtrip
found 2 days ago
Cheap Flights to Southeast Missouri
Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.
Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.
Frequently Asked Questions About flights to Southeast Missouri
Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.
So all you have to worry about is where you’re headed after the STL airport.
What is the cheapest month to fly to Southeast Missouri?
Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in July, but when you book your flight on Hotwire, savings are always in season.
How many airlines fly to Southeast Missouri?
Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.
What airport is best to fly into Southeast Missouri?
When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.
How much are flights to Southeast Missouri?
Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $63, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.
How to get cheap flights to Southeast Missouri?
The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $63 right now, why wait?
Destination airport | Lambert-St. Louis Intl. |
Destination airport IATA code | STL |
Roundtrip price | $209 |
Last Minute Hotel Deals in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (966 reviews)
"The front desk staff was very kind and helpful in spite of being very busy when I arrived. The atmosphere was nice and the building and my room were clean and neat, nicely furnished with newer carpet. It felt new and updated even though the building is older. The view from my room had some lovely ..."
Reviewed on Jun 12, 2025
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive, Cape Girardeau, MO
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,002 reviews)
"Wonderful staff"
Reviewed on Jun 11, 2025
The Riverview
777 Main St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau and Riverfront Park are ...
9.2/10 Wonderful! (296 reviews)
"Clean, average hotel. Bring earplugs, lots of outdoor noise (traffic, river dredging noise etc) We would not stay again due to the noise."
Reviewed on Jun 14, 2025
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (567 reviews)
"Housekeeping is wonderful. All staff was great. Price fair."
Reviewed on Jun 12, 2025
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street, Cape Girardeau, MO
Book a stay at this spa hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
9.4/10 Exceptional! (1,000 reviews)
Great stay
"It was wonderful. Pool and workout room was in great shape and centrally located. Breakfast was amazing and night time cookies and milk was a nice surprise that my daughter didn’t let me forget. The staff was all super nice and I’d definitely stay again if in the area."
Reviewed on Jun 9, 2025
Motel 6 Poplar Bluff, MO
4101 Highway 67 N, Poplar Bluff, MO
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,002 reviews)
"Clean"
Reviewed on Jun 11, 2025
Fairfield Inn & Suites by Marriott Poplar Bluff
3109 Oak Grove, Poplar Bluff, MO
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (758 reviews)
"Nice clean room and updated bathroom. Staff was friendly and helpful. We enjoyed our stay!"
Reviewed on Jun 10, 2025
Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and a fitness center. Our guests praise the helpful staff and the ...
8/10 Very Good! (801 reviews)
Nice Stay
"The stay was amazing and I loved the set-up. The only issue I had was the bed seemed to have been broke on one side but everything else was nice"
Reviewed on Jun 5, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotels
- Baymont Inn and Suites by Wyndham Farmington, MO
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Motel 6 Poplar Bluff, MO
- Fairfield Inn & Suites by Marriott Poplar Bluff
- Candlewood Suites Cape Girardeau by IHG
- Best Western Plus Sikeston
- Days Inn and Suites by Wyndham Sikeston
- Holiday Inn Express & Suites Perryville by IHG