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Southeast Missouri

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Southeast Missouri Flights as Low as $73

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Oct 9 - Fri, Oct 10
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$73 Roundtrip, found 1 day ago
$73
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 9 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 10, priced at $73 found 1 day ago
United
Thu, Oct 16 - Wed, Oct 22
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$117 Roundtrip, found 13 hours ago
$117
Roundtrip
found 13 hours ago
Select United flight, departing Thu, Oct 16 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Wed, Oct 22, priced at $117 found 13 hours ago
Frontier Airlines
Fri, Oct 10 - Fri, Oct 17
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$131 Roundtrip, found 2 days ago
$131
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Fri, Oct 10 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 17, priced at $131 found 2 days ago
Frontier Airlines
Thu, Oct 2 - Fri, Oct 10
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$137 Roundtrip, found 6 days ago
$137
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Thu, Oct 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 10, priced at $137 found 6 days ago
Frontier Airlines
Sun, Oct 5 - Mon, Oct 6
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$140 Roundtrip, found 4 days ago
$140
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, Oct 5 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Oct 6, priced at $140 found 4 days ago
Frontier Airlines
Mon, Oct 6 - Thu, Oct 9
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$142 Roundtrip, found 2 days ago
$142
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Oct 6 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Oct 9, priced at $142 found 2 days ago
Frontier Airlines
Thu, Oct 9 - Sat, Oct 11
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 5 days ago
$144
Roundtrip
found 5 days ago
Select Frontier Airlines flight, departing Thu, Oct 9 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $144 found 5 days ago
Frontier Airlines
Thu, Oct 2 - Thu, Oct 9
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$144 Roundtrip, found 2 days ago
$144
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Thu, Oct 2 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Thu, Oct 9, priced at $144 found 2 days ago
Frontier Airlines
Thu, Oct 9 - Fri, Oct 10
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$146 Roundtrip, found 1 day ago
$146
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 9 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Fri, Oct 10, priced at $146 found 1 day ago
Frontier Airlines
Thu, Oct 30 - Wed, Nov 5
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$146 Roundtrip, found 1 day ago
$146
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Oct 30 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Wed, Nov 5, priced at $146 found 1 day ago
Frontier Airlines
Thu, Sep 18 - Mon, Sep 22
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$148 Roundtrip, found 1 day ago
$148
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Sep 18 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Mon, Sep 22, priced at $148 found 1 day ago
Frontier Airlines
Wed, Oct 15 - Sat, Oct 18
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$194 Roundtrip, found 8 hours ago
$194
Roundtrip
found 8 hours ago
Select Frontier Airlines flight, departing Wed, Oct 15 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Oct 18, priced at $194 found 8 hours ago
Delta
Sun, Nov 2 - Sat, Nov 8
IAH
George Bush Intercontinental
STL
Lambert-St. Louis Intl.
$197 Roundtrip, found 1 day ago
$197
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, Nov 2 from George Bush Intercontinental to Lambert-St. Louis Intl., returning Sat, Nov 8, priced at $197 found 1 day ago
American Airlines
Tue, Oct 14 - Tue, Oct 21
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$199 Roundtrip, found 13 hours ago
$199
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Oct 14 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Tue, Oct 21, priced at $199 found 13 hours ago
Alaska Airlines
Wed, Oct 15 - Sat, Oct 18
SEA
Seattle - Tacoma Intl.
STL
Lambert-St. Louis Intl.
$241 Roundtrip, found 8 hours ago
$241
Roundtrip
found 8 hours ago
Select Alaska Airlines flight, departing Wed, Oct 15 from Seattle - Tacoma Intl. to Lambert-St. Louis Intl., returning Sat, Oct 18, priced at $241 found 8 hours ago
Spirit Airlines
Sat, Oct 11 - Sun, Oct 19
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$274 Roundtrip, found 2 days ago
$274
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sat, Oct 11 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Sun, Oct 19, priced at $274 found 2 days ago

Cheap Flights to Southeast Missouri

Fall in love at first flight with your vacation to Southeast Missouri by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southeast Missouri on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southeast Missouri, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southeast Missouri

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southeast Missouri with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the STL airport.

What is the cheapest month to fly to Southeast Missouri?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southeast Missouri are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southeast Missouri?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Southeast Missouri.

What airport is best to fly into Southeast Missouri?

When you’re planning your trip to Southeast Missouri, convenience is the name of the game. Luckily, Southeast Missouri Cape Girardeau Municipal Airport is nearby so you can deplane and get going on checking off everything on your Southeast Missouri must-do list.

How much are flights to Southeast Missouri?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southeast Missouri on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $73, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southeast Missouri?

The trick to saving a stack of cash on your flight to Southeast Missouri? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $73 right now, why wait?

Southeast Missouri Flight Information
Destination airport
Lambert-St. Louis Intl.
Destination airport IATA code
STL
Roundtrip price
$179

Last Minute Hotel Deals in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Book a stay at this business-friendly hotel in Farmington. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8/10 Very Good! (1,003 reviews)
"Front desk employee very helpful and managed to get us into ground floor room since we have some mobility issues."

Reviewed on Sep 10, 2025

Get rates
Baymont Inn and Suites by Wyndham Farmington, MO
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Stay at this 3-star business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (1,002 reviews)
"No one was at the front desk, you had to call them."

Reviewed on Sep 10, 2025

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Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free WiFi, free parking, and 2 restaurants. Popular attractions Isle Casino Cape Girardeau ...
9.2/10 Wonderful! (414 reviews)
"Clean and no hassle"

Reviewed on Sep 11, 2025

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The Riverview
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St, Caruthersville, MO
Stay at this hotel in Caruthersville. Enjoy free WiFi, free parking, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
8.6/10 Excellent! (409 reviews)
"They do not accept cash! Crazy! Can be very difficult when there is a desire to use a different card than the one used to secure the booking. Be prepared to use the same card!"

Reviewed on Sep 9, 2025

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The Farmstead Hotel
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
Stay at this hotel in Cape Girardeau. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Our guests praise the helpful staff and the clean rooms ...
8.8/10 Excellent! (1,001 reviews)
"Quiet sleep. No microwave in the room. Very inconvenient to have to go back and forth with food."

Reviewed on Sep 11, 2025

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Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Book a stay at this business-friendly hotel in Cape Girardeau. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,000 reviews)
"It's a nice comfortable clean place to stay with a decent breakfast the only problem we were very disappointed as advertised was supposed to be happy hour with appetizers and orders from 5:30 -7 and that is not available never has been!!!"

Reviewed on Sep 5, 2025

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Pear Tree Inn Cape Girardeau West
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD, Jackson, MO
Stay at this 3-star business-friendly hotel in Jackson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (613 reviews)
Good overall
"The only I didn’t like was the bed was uncomfortable to me"

Reviewed on Sep 10, 2025

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La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner, Sikeston, MO
Stay at this 3-star business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,002 reviews)
Great Hotel
"The Drury is a great place to stay with everything you need and want. I recommend this one if you are in this area."

Reviewed on Sep 12, 2025

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Drury Inn & Suites Sikeston, MO
See all 604 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.