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Hotels in Poplar Bluff

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Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
  • 24 min walk from Poplar Bluff Regional Medical Center
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,000 reviews)
The stay this time was just wonderful. The staff was more than helpful when we needed extra things and especially when we got stuck for two extra days from the snow. Normally we just get a regular room but this time decided to do a kitchenette. Best decision ever. Made the hallway smell like bacon ...

Reviewed on Jan 28, 2026

Motel 6 Poplar Bluff, MO
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3 out of 5
2220 N Westwood Blvd Poplar Bluff MO
  • 18 min walk from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (993 reviews)
All of it.

Reviewed on Feb 9, 2026

Drury Inn & Suites Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 out of 5
3109 Oak Grove Poplar Bluff MO
  • 3 min walk from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.2/10 Wonderful! (873 reviews)
Very clean . Every staff member was genuinely friendly and cared about your needs. Very fast check in/out. Breakfast was better than most. Great coffee.

Reviewed on Feb 4, 2026

Fairfield Inn & Suites by Marriott Poplar Bluff
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3 out of 5
2781 N Westwood Blvd Poplar Bluff MO
  • 10 min walk from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
8.6/10 Excellent! (720 reviews)
The front desk woman was great

Reviewed on Dec 21, 2025

Holiday Inn Poplar Bluff by IHG
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 out of 5
2420 Crestwood Dr Poplar Bluff MO
  • 13 min walk from Poplar Bluff Regional Medical Center
Stay at this hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.2/10 Wonderful! (800 reviews)
Clean room, good menu selections, great staff

Reviewed on Jan 26, 2026

Hampton Inn Poplar Bluff
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

2 out of 5
2831 N Westwood Blvd Poplar Bluff MO
  • 10 min walk from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly motel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Popular attractions North Main Street Historic ...
6.4/10 (633 reviews)
Will be staying again. Thank you

Reviewed on Jan 18, 2026

Super 8 by Wyndham Poplar Bluff Missouri
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

2.5 out of 5
2582 N Westwood Blvd Poplar Bluff MO
  • 16 min walk from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.6/10 Good! (404 reviews)
Everything is fine

Reviewed on Jan 21, 2026

Comfort Inn Poplar Bluff North
Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge

2.5 out of 5
399 Hwy T Poplar Bluff MO
  • 7 min drive from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly hotel in Poplar Bluff. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (213 reviews)
A work buddy, and I stayed for 3 nights. Accommodation was very good and we will stay again. When in the area.

Reviewed on Mar 14, 2025

Bullwinkles Rustic Lodge
40-acre Poplar Bluff Nature Lovers Paradise!

40-acre Poplar Bluff Nature Lovers Paradise!

3 out of 5
Poplar Bluff MO
  • 8 min drive from Poplar Bluff Regional Medical Center
Stay at this cottage in Poplar Bluff. Enjoy free parking, patios, and in-room fireplaces.
10/10 Exceptional! (3 reviews)
Beautiful place enjoyed our stay

Reviewed on Apr 4, 2025

40-acre Poplar Bluff Nature Lovers Paradise!
Waterfront Home Near Mark Twain National Forest

Waterfront Home Near Mark Twain National Forest

3.5 out of 5
Poplar Bluff MO
  • 4 min drive from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly apartment in Poplar Bluff. Enjoy free parking and air conditioning. Popular attractions Ozark Ridge Golf Course and North ...
Waterfront Home Near Mark Twain National Forest
Travelodge by Wyndham Dexter

Travelodge by Wyndham Dexter

2 out of 5
1608 E Business US 60 Dexter MO
  • 48 min drive from Poplar Bluff Regional Medical Center
Book a stay at this business-friendly hotel in Dexter. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions The Heritage House and Keller ...
7.4/10 Good! (392 reviews)
Everything is nice accept the Direct tv never works and their internet is terrible. Other than those 2 things it has been pleasant staying here. The manager corrected the problem with our checking in and the staff not knowing what to do. The cleaning staff is very nice and accommodating. The room ...

Reviewed on Jan 10, 2026

Travelodge by Wyndham Dexter
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

2.5 out of 5
2179 Gill Plaza Drive Dexter MO
  • 46 min drive from Poplar Bluff Regional Medical Center
Stay at this hotel in Dexter. Popular attractions The Heritage House and Keller Veteran Memorial are located nearby.
10/10 Exceptional! (11 reviews)
Amazing hotel that Dexter so desperately needed. Everything was immaculate, and the breakfast was exceptional. Super friendly staff too! I’m already looking forward to my next visit..

Reviewed on Feb 8, 2026

Hampton Inn By Hilton Dexter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Poplar Bluff

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How many hotels are there in Poplar Bluff?

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