Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Book with Confidence. Price Match Guarantee.

No Hotwire Cancellation Fee

We've Saved Customers over $3.1 Billion

Hotels in Santo Antonio

Estimated price for 1 night/2 adults


Best Times to Stay in Santo Antonio

*Estimated average price per night / 3-star hotel. Prices may vary.
$72 avg/night*
$127 avg/night*

Santo Antonio Hotel Guide

Search for hotels in Santo Antonio on Hotwire. You can easily find your hotels in Santo Antonio using one of the methods below:

  • View our selection of featured hotels in Santo Antonio
  • Use the map to find hotels in the Santo Antonio neighborhood you prefer
  • Use the filters to see hotels in a specific area of Santo Antonio, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Santo Antonio
  • Enter your travel dates to view the best deals on hotels in Santo Antonio - while they last