Search Deals onMatlacha Isles Vacation Packages
Matlacha Isles Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Comfort Inn & Suites
per person
Jun 12 - Jun 16
found 7 hours ago
Roundtrip flight included
Chicago (ORD) to Fort Myers (RSW)
Book a stay at this business-friendly hotel in Port Charlotte. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Deep Creek Golf Club and Lake Betty Park are located nearby.
Lani Kai Beachfront Resort
Save 100% on your flight
per person
Jun 6 - Jun 13
found 9 hours ago
Roundtrip non-stop flight included
Albany (ALB) to Fort Myers (RSW)
Stay at this 3.5-star beach hotel in Fort Myers Beach. Enjoy free WiFi, an outdoor pool, and a beach locale. Popular attractions Key West Express and Times Square are located nearby.
Naples Grande Beach Resort
Park Shore
Save 100% on your flight
per person
Jun 7 - Jun 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
Stay at this 4.5-star luxury resort in Naples. Enjoy 3 outdoor pools, a full-service spa, and 3 restaurants. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Vanderbilt Beach and Naples Zoo at Caribbean Gardens are located nearby.
Edison Beach House
per person
Jun 22 - Jun 26
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
Stay at this 3.5-star beach aparthotel in Fort Myers Beach. Enjoy free parking, a beach locale, and daily housekeeping. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Key West Express and Times Square are located nearby.
Hilton Naples
Central Naples
per person
Jun 7 - Jun 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
Book a stay at this business-friendly hotel in Naples. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Naples Zoo at Caribbean Gardens and Vanderbilt Beach are located nearby.
Bellasera Resort
Old Naples
Save 100% on your flight
per person
Jun 7 - Jun 14
found 1 day ago
Roundtrip flight included
Boston (BOS) to Fort Myers (RSW)
Book a stay at this business-friendly condo in Naples. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the pool and the bar in our reviews. Popular attractions Fifth Avenue South and Naples Pier are located nearby.
Sanibel Island Beach Resort
Save 100% on your flight
per person
Jun 6 - Jun 13
found 9 hours ago
Roundtrip non-stop flight included
Albany (ALB) to Fort Myers (RSW)
Stay at this 3-star beach hotel in Sanibel. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the pool and the restaurant in our reviews. Popular attractions Sanibel Island Southern Beach and Sanibel Island Golf Club are located nearby.
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
per person
Jun 6 - Jun 13
found 9 hours ago
Roundtrip non-stop flight included
Albany (ALB) to Fort Myers (RSW)
Book a stay at this business-friendly hotel in Fort Myers. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Key West Express and San Carlos Bay - Bunche Beach Preserve are located nearby.
3-4 Night Vacations in Matlacha Isles
Price found within the past 48 hours. Click for updated prices.
5-7 Night Vacations in Matlacha Isles
Price found within the past 48 hours. Click for updated prices.
Cheap Hotel Deals in Matlacha Isles
Margaritaville Beach Resort Fort Myers
251 Crescent Street, Fort Myers Beach, FL
Stay at this 4-star beach hotel in Fort Myers Beach. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the pool and the helpful staff ...
Sanibel Island Beach Resort
1231 Middle Gulf Dr, Sanibel, FL
Stay at this 3-star beach hotel in Sanibel. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the pool and the restaurant in our reviews. ...
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
1538 Cape Coral Pkwy E, Cape Coral, FL
Book a stay at this business-friendly hotel in Cape Coral. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Save an average of 15% on thousands of hotels when you're signed in
Marriott Sanibel Harbour Resort & Spa
17260 Harbour Pointe Dr, Fort Myers, FL
Book a stay at this spa resort in Fort Myers. Enjoy 3 outdoor pools, a full-service spa, and 4 restaurants. Our guests praise the helpful staff and the property ...
Lani Kai Beachfront Resort
1400 Estero Blvd, Fort Myers Beach, FL
Stay at this 3.5-star beach hotel in Fort Myers Beach. Enjoy free WiFi, an outdoor pool, and a beach locale. Popular attractions Key West Express and Times Square ...
Pink Shell Beach Resort and Marina
275 Estero Blvd, Fort Myers Beach, FL
Stay at this 4-star beach resort in Fort Myers Beach. Enjoy free breakfast, 3 outdoor pools, and 3 restaurants. Our guests praise the breakfast and the pool ...
DiamondHead Beach Resort
2000 Estero Blvd, Fort Myers Beach, FL
Stay at this 3.5-star beach resort in Fort Myers Beach. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the pool and the helpful staff in ...
The Lighthouse Resort Inn & Suites
1051 5th St, Fort Myers Beach, FL
Stay at this 3-star hotel in Fort Myers Beach. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the bar in our reviews. Popular ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Sun, May 25 - Thu, May 29
CLE
Hopkins Intl.
RSW
Southwest Florida Intl.
$111 Roundtrip, found 1 day ago
$111
Roundtrip
found 1 day ago
Tue, Sep 9 - Sat, Sep 13
ORD
O'Hare Intl.
RSW
Southwest Florida Intl.
$114 Roundtrip, found 4 days ago
$114
Roundtrip
found 4 days ago
Sun, Jun 15 - Sat, Jun 21
DTW
Detroit Metropolitan Wayne County
RSW
Southwest Florida Intl.
$132 Roundtrip, found 14 hours ago
$132
Roundtrip
found 14 hours ago
Sun, May 25 - Thu, May 29
PHL
Philadelphia Intl.
RSW
Southwest Florida Intl.
$145 Roundtrip, found 1 day ago
$145
Roundtrip
found 1 day ago