Search for Cheap Deals on
Hotels in Pamplico

Check Last Minute Pamplico Hotel Deals

Tonight Nov 30 - Dec 1Next weekend Dec 5 - Dec 7

Choose from 142 Pamplico Hotel Deals

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,459 reviews)
What a nice place. Certainly the Gem of the hotels at this exit for sure. Great staff, nice and friendly, found the exact room I needed and it was so clean. In good repair too. Parking lot had good lighting so my car was safe and close to the room. Breakfast was nice. The coffee was the best. I don't ...

Reviewed on Nov 24, 2025

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
8.8/10 Excellent! (2,200 reviews)
Rooms clean

Reviewed on Nov 23, 2025

Park Inn by Radisson Florence, SC
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,165 reviews)
Noce staff clean room pretty new

Reviewed on Nov 26, 2025

Comfort Inn & Suites Florence Center Area
La Quinta Inn & Suites by Wyndham Florence

La Quinta Inn & Suites by Wyndham Florence

3 out of 5
2123 W Lucas St Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,693 reviews)
Hotel was in a great location. Room was clean and comfortable. All staff I encountered was very friendly and knowledgeable.

Reviewed on Nov 24, 2025

La Quinta Inn & Suites by Wyndham Florence
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

3 out of 5
100 East Evans Street Florence Florence SC
  • 11 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff and ...
8.8/10 Excellent! (1,008 reviews)
Clean rooms, Nice staff, good food and drinks. Overall great experience!!!

Reviewed on Nov 23, 2025

Hyatt Place Florence Downtown
Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95

2.5 out of 5
1735 Stokes Road Florence SC
  • 9 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.8/10 Excellent! (794 reviews)
We were only there for a few hours, but everything was just fine.

Reviewed on Nov 22, 2025

Hampton Inn & Suites Florence-North-I-95
Home2 Suites by Hilton Florence, SC

Home2 Suites by Hilton Florence, SC

3 out of 5
900 Woody Jones Blvd Florence SC
  • 4 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,010 reviews)
Pet friendly and easy on off I 95

Reviewed on Nov 22, 2025

Home2 Suites by Hilton Florence, SC
Tru by Hilton Florence I-95

Tru by Hilton Florence I-95

2.5 out of 5
2140 West Lucas Street Florence SC
  • 10 min drive from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,012 reviews)
Internet was good. Remote on TV was slow

Reviewed on Nov 25, 2025

Tru by Hilton Florence I-95
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
  • 9 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,257 reviews)
The room was modern and very clean. The area felt safe. There were plenty of stores and restaurants in walking distance as the hotel is located within a large shopping area. But, the absolute best part of the stay was the woman at the front desk that checked me in. She was very nice, efficient and ...

Reviewed on Nov 23, 2025

Quality Inn & Suites Florence Civic Center
TownePlace Suites by Marriott Florence

TownePlace Suites by Marriott Florence

3 out of 5
2650 Hospitality Boulevard Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.8/10 Excellent! (693 reviews)
Room were very clean and staff was very friendly.

Reviewed on Nov 28, 2025

TownePlace Suites by Marriott Florence
Residence Inn Marriott Florence

Residence Inn Marriott Florence

3 out of 5
2660 Hospitality Blvd Florence SC
  • 4 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (464 reviews)
Friendly staff, comfy, clean room.

Reviewed on Nov 26, 2025

Residence Inn Marriott Florence
Courtyard by Marriott Florence

Courtyard by Marriott Florence

3 out of 5
2680 Hospitality Blvd Florence SC
  • 7 min walk from Florence Civic Center
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
7.8/10 Good! (695 reviews)
Clean room and staff was very friendly.

Reviewed on Nov 26, 2025

Courtyard by Marriott Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Pamplico

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Pamplico hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Pamplico.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Pamplico’s 142 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $70. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Pamplico hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Pamplico. No matter your reason for visiting Pamplico, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Pamplico hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Pamplico for as low as $70.

How many hotels are there in Pamplico?

With over 142 hotels in Pamplico, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $70.

How to find cheap car rentals in Pamplico?

Finding a cheap car rental deal in Pamplico is as easy as scoring cheap hotels in Pamplico. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.