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East Prairie

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East Prairie Flights as Low as $500

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Tue, Jul 14 - Sat, Jul 18
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$500 Roundtrip, found 6 days ago
$500
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jul 14 from Tampa Intl. to Cape Girardeau Municipal, returning Sat, Jul 18, priced at $500 found 6 days ago
American Airlines
Tue, Jul 14 - Sat, Jul 18
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$555 Roundtrip, found 6 days ago
$555
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jul 14 from Tampa Intl. to Cape Girardeau Municipal, returning Sat, Jul 18, priced at $555 found 6 days ago
American Airlines
Tue, Jul 14 - Sat, Jul 18
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$559 Roundtrip, found 4 days ago
$559
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jul 14 from Tampa Intl. to Cape Girardeau Municipal, returning Sat, Jul 18, priced at $559 found 4 days ago
American Airlines
Tue, Jul 14 - Sat, Jul 18
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$565 Roundtrip, found 6 days ago
$565
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jul 14 from Tampa Intl. to Cape Girardeau Municipal, returning Sat, Jul 18, priced at $565 found 6 days ago
American Airlines
Tue, Jul 14 - Sat, Jul 18
TPA
Tampa Intl.
CGI
Cape Girardeau Municipal
$568 Roundtrip, found 6 days ago
$568
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, Jul 14 from Tampa Intl. to Cape Girardeau Municipal, returning Sat, Jul 18, priced at $568 found 6 days ago
American Airlines
Wed, Jul 29 - Sat, Aug 1
FLO
Florence Regional
CGI
Cape Girardeau Municipal
$587 Roundtrip, found 3 days ago
$587
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 29 from Florence Regional to Cape Girardeau Municipal, returning Sat, Aug 1, priced at $587 found 3 days ago
American Airlines
Tue, Jul 7 - Tue, Jul 14
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$598 Roundtrip, found 4 days ago
$598
Roundtrip
found 4 days ago
Select American Airlines flight, departing Tue, Jul 7 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Tue, Jul 14, priced at $598 found 4 days ago
United
Wed, Jul 8 - Wed, Jul 15
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$599 Roundtrip, found 4 days ago
$599
Roundtrip
found 4 days ago
Select United flight, departing Wed, Jul 8 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Wed, Jul 15, priced at $599 found 4 days ago
United
Thu, Jul 9 - Mon, Jul 13
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$609 Roundtrip, found 4 days ago
$609
Roundtrip
found 4 days ago
Select United flight, departing Thu, Jul 9 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Mon, Jul 13, priced at $609 found 4 days ago
United
Wed, Jul 8 - Mon, Jul 13
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$609 Roundtrip, found 4 days ago
$609
Roundtrip
found 4 days ago
Select United flight, departing Wed, Jul 8 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Mon, Jul 13, priced at $609 found 4 days ago
United
Sat, Jul 4 - Wed, Jul 15
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$610 Roundtrip, found 4 days ago
$610
Roundtrip
found 4 days ago
Select United flight, departing Sat, Jul 4 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Wed, Jul 15, priced at $610 found 4 days ago
United
Sat, Jul 4 - Mon, Jul 13
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$621 Roundtrip, found 4 days ago
$621
Roundtrip
found 4 days ago
Select United flight, departing Sat, Jul 4 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Mon, Jul 13, priced at $621 found 4 days ago
American Airlines
Fri, Nov 13 - Mon, Nov 16
FLO
Florence Regional
CGI
Cape Girardeau Municipal
$626 Roundtrip, found 4 days ago
$626
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Nov 13 from Florence Regional to Cape Girardeau Municipal, returning Mon, Nov 16, priced at $626 found 4 days ago
American Airlines
Sat, Jul 11 - Wed, Jul 15
BWI
Baltimore Washington Intl. Thurgood Marshall
CGI
Cape Girardeau Municipal
$631 Roundtrip, found 1 day ago
$631
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Jul 11 from Baltimore Washington Intl. Thurgood Marshall to Cape Girardeau Municipal, returning Wed, Jul 15, priced at $631 found 1 day ago
American Airlines
Mon, Jul 6 - Tue, Jul 14
CMH
John Glenn Columbus Intl.
CGI
Cape Girardeau Municipal
$638 Roundtrip, found 4 days ago
$638
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jul 6 from John Glenn Columbus Intl. to Cape Girardeau Municipal, returning Tue, Jul 14, priced at $638 found 4 days ago
United
Tue, Jul 7 - Tue, Jul 14
BWI
Baltimore Washington Intl. Thurgood Marshall
CGI
Cape Girardeau Municipal
$641 Roundtrip, found 2 days ago
$641
Roundtrip
found 2 days ago
Select United flight, departing Tue, Jul 7 from Baltimore Washington Intl. Thurgood Marshall to Cape Girardeau Municipal, returning Tue, Jul 14, priced at $641 found 2 days ago

Cheap Flights to East Prairie

Fall in love at first flight with your vacation to East Prairie by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to East Prairie on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in East Prairie, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to East Prairie

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to East Prairie with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the CGI airport.

What is the cheapest month to fly to East Prairie?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to East Prairie are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to East Prairie?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to East Prairie.

What airport is best to fly into East Prairie?

When you’re planning your trip to East Prairie, convenience is the name of the game. Luckily, East Prairie Cairo Regional Airport is nearby so you can deplane and get going on checking off everything on your East Prairie must-do list.

How much are flights to East Prairie?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to East Prairie on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $500, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to East Prairie?

The trick to saving a stack of cash on your flight to East Prairie? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $500 right now, why wait?

East Prairie Flight Information
Destination airport
Cape Girardeau Municipal
Destination airport IATA code
CGI
Roundtrip price
$500

Last Minute Hotel Deals in East Prairie

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,004 reviews)
"Quick check-in. Room was very clean and nice. Staff was helpful. Would definitely stay here again."

Reviewed on Jun 28, 2026

Get rates
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
"Rooms are nice and clean although fixtures could be updated. There is no central air and heat, room is cooled by a wall unit. Room was extremely hot when I first entered."

Reviewed on Jun 24, 2026

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Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,004 reviews)
"The staff are really nice and friendly. Breakfast is very good too. Pretty close to a convenience store. Only problem was the musty smell through the hallways and into the room. We had to fan out the room before staying inside for too long. We also saw a dead cockroach on the window."

Reviewed on Jun 28, 2026

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Best Western Plus Sikeston I-55
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (583 reviews)
"Staff was great, room was clean and breakfast was verry good."

Reviewed on Jun 28, 2026

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Hampton Inn Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

2.5 out of 5
1111 BLue Heron Lane Union City TN
Book a stay at this business-friendly hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Discovery Park of America and ...
9.2/10 Wonderful! (400 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."

Reviewed on Jun 14, 2026

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Sleep Inn at Discovery Park of America
Quality Inn Union City US 51

Quality Inn Union City US 51

2.5 out of 5
2201 W Reelfoot Ave Union City TN
Stay at this hotel in Union City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.2/10 Very Good! (528 reviews)
"Clean up the area"

Reviewed on Jun 25, 2026

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Quality Inn Union City US 51
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 out of 5
100 Matthews Lane Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (793 reviews)
"Clean updated room, but thin walls, so can be noisy when there are a lot of guests. Bed was comfortable. Excellent value for the cost. Good location - near lots of green space for dogs. Also next door to McDonalds and Burger King."

Reviewed on Jun 25, 2026

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Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

3 out of 5
1239 Commerce Drive Sikeston MO
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Central Park and Sikeston Depot ...
9.4/10 Exceptional! (96 reviews)
"It was absolutely wonderful! The staff was helpful, and I loved how clean everything was!"

Reviewed on Jun 24, 2026

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Fairfield Inn & Suites by Marriott Sikeston
See all 90 properties in East Prairie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.