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Hotels in Upstate South Carolina

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Last Minute Hot Rate® Hotel Deals in Upstate South Carolina

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Choose from 2553 Upstate South Carolina Hotel Deals

La Quinta Inn & Suites by Wyndham Greenville Haywood
La Quinta Inn & Suites by Wyndham Greenville Haywood
2.5 out of 5
65 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
The price is $73 per night from May 19 to May 20
$73
per night
May 19 - May 20
Stay at this hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,000 reviews)
"Ataff was well mannered"

Reviewed on Apr 30, 2024

La Quinta Inn & Suites by Wyndham Greenville Haywood
Hilton Greenville
Hilton Greenville
3.5 out of 5
45 W Orchard Park Dr, Greenville, SC
  • 1 hour drive from Clemson University
The price is $103 per night from May 26 to May 27
$103
per night
May 26 - May 27
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and ...
8/10 Very Good! (1,001 reviews)
"Was a nice hotel for a quick get away with my wife."

Reviewed on Apr 29, 2024

Hilton Greenville
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
3.5 out of 5
851 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $104 per night from May 26 to May 27
$104
per night
May 26 - May 27
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (969 reviews)
Great
"Great stay over!"

Reviewed on Apr 29, 2024

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd, an IHG Hotel
Hyatt Regency Greenville
Hyatt Regency Greenville
3.5 out of 5
220 N Main St, Greenville, SC
  • 1 hour drive from Clemson University
The price is $152 per night from May 19 to May 20
$152
per night
May 19 - May 20
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, an outdoor pool, and 2 bars/lounges. Our guests praise the helpful staff and the ...
8.6/10 Excellent! (1,003 reviews)
"Hotel had a perfect location wonderful lobby and room was very clean. Only bad thing is our Bottom sheets on the bed were put on sideways on both beds, therefore your feet were touching the mattress cover and there was about 3 feet on each side that was hanging to the floor. Very strange we had to ..."

Reviewed on May 1, 2024

Hyatt Regency Greenville
Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & Suites
2.5 out of 5
831 Congaree Rd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $85 per night from May 12 to May 13
$85
per night
May 12 - May 13
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,180 reviews)
"Great stay for low price!"

Reviewed on Apr 30, 2024

Best Western Plus Greenville I-385 Inn & Suites
Hotel Hartness
Hotel Hartness
4 out of 5
120 Halston Avenue, Greenville, SC
  • 2 hours drive from Clemson University
The price is $151 per night from May 19 to May 20
$151
per night
May 19 - May 20
Stay at this 4-star spa hotel in Greenville. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (176 reviews)
"Loved everything! My wife and myself couldn’t have chose a better place to enjoy a peaceful relaxing weekend. Their rooms were very clean and comfortable. The property was beautifully maintained with ample space to enjoy the outdoor environment and activities. Would highly recommend to anyone looking ..."

Reviewed on Apr 30, 2024

Hotel Hartness
Comfort Inn Greenville - Haywood Mall
Comfort Inn Greenville - Haywood Mall
2.5 out of 5
246 Congaree Road, Greenville, SC
  • 1 hour drive from Clemson University
The price is $80 per night from May 12 to May 13
$80
per night
May 12 - May 13
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
7.8/10 Good! (1,003 reviews)
"Very good!"

Reviewed on Apr 30, 2024

Comfort Inn Greenville - Haywood Mall
Midtown Suites-Greenville
Midtown Suites-Greenville
2.5 out of 5
11 Ketron Court, Greenville, SC
  • 1 hour drive from Clemson University
The price is $74 per night from May 5 to May 6
$74
per night
May 5 - May 6
Book a stay at this business-friendly hotel in Greenville. Enjoy free WiFi, a 24-hour front desk, and a 24-hour business center. Our guests praise the helpful ...
8.6/10 Excellent! (1,002 reviews)
Peace on 🌎
"Peaceful, quiet, everyone minds their own garden. Making a notable transition soon so stay up to date! They will have more to offer."

Reviewed on May 1, 2024

Midtown Suites-Greenville
Grand Bohemian Lodge Greenville, Autograph Collection
Grand Bohemian Lodge Greenville, Autograph Collection
4 out of 5
44 EAST CAMPERDOWN WAY, Greenville, SC
  • 1 hour drive from Clemson University
The price is $332 per night from May 27 to May 28
$332
per night
May 27 - May 28
Stay at this 4-star spa hotel in Greenville. Enjoy a full-service spa, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
9.4/10 Exceptional! (182 reviews)
"The property is a great location. The waterfall is beautiful to be able to see. Unfortunately, our room had a device on the wall that a white light flashed from it every 3 seconds all night. We had a hard time sleeping. I told the girl what happened when I checked out, and she said she would tell ..."

Reviewed on May 1, 2024

Grand Bohemian Lodge Greenville, Autograph Collection
Hyatt Place Greenville/Downtown
Hyatt Place Greenville/Downtown
3 out of 5
128 East Broad Street, Greenville, SC
  • 1 hour drive from Clemson University
The price is $161 per night from May 12 to May 13
$161
per night
May 12 - May 13
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
9/10 Wonderful! (1,021 reviews)
"Our stay was very pleasant. The only issue was tgat we arrived at 1am. We paid for parking but there was no valet on duty. We were asked to park the car in the back of the building and they said they would take care of it. Although they asked us to hold onto tge keys. We were awoken at 7am as they ..."

Reviewed on Apr 24, 2024

Hyatt Place Greenville/Downtown
Drury Inn & Suites Greenville
Drury Inn & Suites Greenville
3 out of 5
10 Carolina Point Pkwy, Greenville, SC
  • 2 hours drive from Clemson University
The price is $117 per night from May 26 to May 27
$117
per night
May 26 - May 27
Stay at this 3-star business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,001 reviews)
Satisfied ❤️
"Very clean, friendly, comfortable and hospitable place to stay."

Reviewed on May 1, 2024

Drury Inn & Suites Greenville
Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference Center
3.5 out of 5
670 Verdae Blvd, Greenville, SC
  • 1 hour drive from Clemson University
The price is $116 per night from May 26 to May 27
$116
per night
May 26 - May 27
Book a stay at this golf hotel in Greenville. Enjoy free breakfast, a golf course, and a free airport shuttle. Our guests praise the breakfast and the helpful ...
8.8/10 Excellent! (1,003 reviews)
"Everything"

Reviewed on Apr 28, 2024

Embassy Suites Greenville Golf Resort & Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

HOTW-Hotel-Deals-726-959@2x.jpg (1918×258)*Savings based on Hot Rate® hotel bookings as compared with the lowest published rates found on leading retail travel sites. Hot Rates are different from retail rates. With Hot Rates you enter the date, location and star rating. Hotel revealed only after booking. All bookings final.

Find cheap hotels in Upstate South Carolina

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Upstate South Carolina hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Upstate South Carolina.

Choosing the right hotel in South Carolina has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Upstate South Carolina’s 2,553 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $73. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Upstate South Carolina hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Upstate South Carolina. No matter your reason for visiting Upstate South Carolina, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Upstate South Carolina hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Upstate South Carolina for as low as $73.

How many hotels are there in Upstate South Carolina?

With over 2,553 hotels in Upstate South Carolina, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $73.

How to find cheap car rentals in Upstate South Carolina?

Finding a cheap car rental deal in Upstate South Carolina is as easy as scoring cheap hotels in Upstate South Carolina. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Upstate South Carolina now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Upstate South Carolina right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.