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Mississippi River Vacation Packages

Mississippi River Flight + Hotel Packages

Freehand Chicago

Freehand Chicago

4 out of 5
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Stay at this 4-star hotel in Chicago. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the bar and the helpful staff in our reviews. Popular attractions Michigan Avenue and Chicago Riverwalk are located nearby. Discover genuine guest reviews for Freehand Chicago, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
NOPSI Hotel, New Orleans

NOPSI Hotel, New Orleans

4.5 out of 5
per person
Jun 13 - Jun 17
Roundtrip non-stop flight included
Buffalo (BUF) to New Orleans (MSY)
Stay at this 4.5-star luxury hotel in New Orleans. Enjoy free WiFi, 3 bars/lounges, and a rooftop terrace. Our guests praise the pool and the restaurant in our reviews. Popular attractions Canal Street and Caesars Superdome are located nearby. Discover genuine guest reviews for NOPSI Hotel, New Orleans, in New Orleans Central Business District neighborhood, along with the latest prices and availability – book now.
voco Chicago Downtown, an IHG Hotel

voco Chicago Downtown, an IHG Hotel

3.5 out of 5
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Stay at this 3.5-star business-friendly hotel in Chicago. Enjoy free WiFi, breakfast, and a 24-hour fitness center. Our guests praise the breakfast and the pool in our reviews. Popular attractions Chicago Riverwalk and Willis Tower are located nearby. Discover genuine guest reviews for voco Chicago Downtown, an IHG Hotel, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
Chez Hotel Arlington Heights

Chez Hotel Arlington Heights

3.5 out of 5
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Stay at this 3.5-star hotel in Arlington Heights. Enjoy free WiFi, free parking, and breakfast. Popular attractions LEGOLAND® Discovery Center and Woodfield Mall are located nearby. Discover genuine guest reviews for Chez Hotel Arlington Heights along with the latest prices and availability – book now.
Trump International Hotel & Tower Chicago

Trump International Hotel & Tower Chicago

5 out of 5
per person
Jun 6 - Jun 10
Roundtrip non-stop flight included
Dallas (DAL) to Chicago (ORD)
Stay at this 5-star luxury hotel in Chicago. Enjoy free WiFi, a full-service spa, and breakfast. Our guests praise the restaurant and the helpful staff in our reviews. Popular attractions Chicago Riverwalk and Michigan Avenue are located nearby. Discover genuine guest reviews for Trump International Hotel & Tower Chicago, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
LondonHouse Chicago, Curio Collection by Hilton

LondonHouse Chicago, Curio Collection by Hilton

4.5 out of 5
per person
Jun 6 - Jun 10
Roundtrip non-stop flight included
Dallas (DAL) to Chicago (ORD)
Stay at this 4.5-star luxury hotel in Chicago. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. Popular attractions Chicago Riverwalk and Michigan Avenue are located nearby. Discover genuine guest reviews for LondonHouse Chicago, Curio Collection by Hilton, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
Lively 4BR Condo Steps to French Quarter Unit 518

Lively 4BR Condo Steps to French Quarter Unit 518

4.5 out of 5
Save 100% on your flight
per person
May 21 - May 25
Roundtrip non-stop flight included
Las Vegas (LAS) to New Orleans (MSY)
Stay at this 4.5-star luxury aparthotel in New Orleans. Enjoy free WiFi, a fitness center, and a terrace. Popular attractions Canal Street and Caesars Superdome are located nearby. Discover genuine guest reviews for Lively 4BR Condo Steps to French Quarter Unit 518, in New Orleans Central Business District neighborhood, along with the latest prices and availability – book now.
Virgin Hotels Chicago

Virgin Hotels Chicago

4.5 out of 5
per person
Jun 6 - Jun 10
Roundtrip non-stop flight included
Dallas (DAL) to Chicago (ORD)
Stay at this 4.5-star luxury hotel in Chicago. Enjoy free WiFi, a nightclub, and a rooftop terrace. Our guests praise the restaurant and the bar in our reviews. Popular attractions Chicago Riverwalk and Millennium Park are located nearby. Discover genuine guest reviews for Virgin Hotels Chicago, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
DoubleTree by Hilton Chicago - Magnificent Mile

DoubleTree by Hilton Chicago - Magnificent Mile

4 out of 5
per person
Jun 6 - Jun 10
Roundtrip non-stop flight included
Dallas (DAL) to Chicago (ORD)
Stay at this business-friendly hotel in Chicago. Enjoy an outdoor pool, a rooftop terrace, and breakfast. Our guests praise the pool and the restaurant in our reviews. Popular attractions Michigan Avenue and Chicago Riverwalk are located nearby. Discover genuine guest reviews for DoubleTree by Hilton Chicago - Magnificent Mile, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
Kasa Magnificent Mile Chicago

Kasa Magnificent Mile Chicago

4 out of 5
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Stay at this 4-star hotel in Chicago. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the clean rooms in our reviews. Popular attractions Michigan Avenue and Chicago Riverwalk are located nearby. Discover genuine guest reviews for Kasa Magnificent Mile Chicago, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
Chicago Marriott Downtown Magnificent Mile

Chicago Marriott Downtown Magnificent Mile

4 out of 5
per person
Jun 6 - Jun 10
Roundtrip non-stop flight included
Dallas (DAL) to Chicago (ORD)
Stay at this business-friendly hotel in Chicago. Enjoy 2 restaurants, a rooftop terrace, and breakfast. Our guests praise the bar and the helpful staff in our reviews. Popular attractions Michigan Avenue and Chicago Riverwalk are located nearby. Discover genuine guest reviews for Chicago Marriott Downtown Magnificent Mile, in Downtown Chicago neighborhood, along with the latest prices and availability – book now.
Inn on St Ann

Inn on St Ann

3 out of 5
per person
Jun 13 - Jun 17
Roundtrip non-stop flight included
Buffalo (BUF) to New Orleans (MSY)
Stay at this 3-star historic hotel in New Orleans. Enjoy free WiFi, a 24-hour front desk, and a terrace. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Bourbon Street and Canal Street are located nearby. Discover genuine guest reviews for Inn on St Ann, in French Quarter neighborhood, along with the latest prices and availability – book now.
Prices and availability subject to change. Additional terms may apply.

3-4 Night Vacations in Mississippi River

Fairmont Chicago at Millennium Park Gold Experience

Fairmont Chicago at Millennium Park Gold Experience

4.5 out of 5
Downtown Chicago
Save 100% on your flight
per person
May 23 - May 26
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Park Hyatt Chicago

Park Hyatt Chicago

5 out of 5
Downtown Chicago
Save 100% on your flight
per person
May 24 - May 27
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
NOPSI Hotel, New Orleans

NOPSI Hotel, New Orleans

4.5 out of 5
New Orleans Central Business District
per person
Jun 13 - Jun 17
Roundtrip non-stop flight included
Buffalo (BUF) to New Orleans (MSY)
The Chicago Hotel Collection - Wrigleyville

The Chicago Hotel Collection - Wrigleyville

3.5 out of 5
Lakeview
Save 100% on your flight
per person
May 23 - May 26
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Prices and availability subject to change. Additional terms may apply.

5-7 Night Vacations in Mississippi River

Level Chicago – Old Town

Level Chicago – Old Town

4 out of 5
Downtown Chicago
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Freehand Chicago

Freehand Chicago

4 out of 5
Downtown Chicago
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
voco Chicago Downtown, an IHG Hotel

voco Chicago Downtown, an IHG Hotel

3.5 out of 5
Downtown Chicago
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
The Allegro Royal Sonesta Hotel Chicago Loop

The Allegro Royal Sonesta Hotel Chicago Loop

4 out of 5
Downtown Chicago
Save 100% on your flight
per person
May 21 - May 28
Roundtrip flight included
Dallas (DFW) to Chicago (ORD)
Prices and availability subject to change. Additional terms may apply.

Mississippi River Last Minute Hotel Deals

La Quinta Inn & Suites by Wyndham St. Louis Westport
La Quinta Inn & Suites by Wyndham St. Louis Westport
2.5 out of 5
11805 Lackland Rd, Maryland Heights, MO
Stay at this business-friendly hotel in Maryland Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suites by Wyndham St. Louis Westport
Hollywood Casino & Hotel St. Louis
Hollywood Casino & Hotel St. Louis
3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants, and a casino. Our guests praise the helpful staff and the convenient ...
Hollywood Casino & Hotel St. Louis
Hyatt Regency St. Louis at The Arch
Hyatt Regency St. Louis at The Arch
4 out of 5
315 Chestnut St, St. Louis, MO
Stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms ...
Hyatt Regency St. Louis at The Arch
Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the helpful ...
Clayton Plaza Hotel & Extended Stay
Best Western St. Louis-Kirkwood Route 66
Best Western St. Louis-Kirkwood Route 66
2.5 out of 5
1200 S Kirkwood Road, Kirkwood, MO
Stay at this business-friendly hotel in Kirkwood. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Best Western St. Louis-Kirkwood Route 66
Drury Plaza Hotel St. Louis at the Arch
Drury Plaza Hotel St. Louis at the Arch
3 out of 5
2 South 4th Street, St. Louis, MO
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
Drury Plaza Hotel St. Louis at the Arch
Pear Tree Inn St. Louis Airport
Pear Tree Inn St. Louis Airport
2.5 out of 5
10810 Pear Tree Ln, St. Ann, MO
Stay at this business-friendly hotel in St. Ann. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Pear Tree Inn St. Louis Airport
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
2.5 out of 5
333 Washington Ave, St. Louis, MO
Stay at this family-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the pool ...
Hampton Inn St. Louis-Downtown (At the Gateway Arch)
See all 15,053 properties in Mississippi River
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Book the perfect getaway to Mississippi River

With Hotwire, booking your next trip to United States of America is a breeze. When it comes to planning a show-stopping vacay, you’re the reigning champion of doing it on a dime. You love to plan exciting destination adventures while saving money on a budget.

Hotwire is here to help you plan a smooth sailing trip to Mississippi River while saving some major cash. Doubling up on vacation expenses like hotel and car rentals and fun-filled excursions can save you money—especially when you book one of Hotwire’s vacation packages.

If your trip to is spur-of-the-moment and you’re leaving soon, Hotwire can save you up to 60% off your rentals with Hotwire Hot Rate deals. Book with Hotwire to grab a stellar Mississippi River flight and hotel package for as low as $576.

Living it up in United States of America means getting there in style and staying in a hotel that matches your mood. Book one of Hotwire’s Mississippi River, United States of America vacation packages to enjoy the best of both worlds. Flight and hotel packages typically include roundtrip non-stop flights and multi-day hotel stays. Packages are priced per person and are perfect for flying solo or traveling with a group of friends or family. Conveniently choose from Hotwire’s inventory of hotels in Mississippi River for some of the best accommodations and flight deals.

FAQs about cheap Mississippi River packages:

How to get cheap vacation deals to Mississippi River?

Save up to 60% off vacation deals with Hotwire Hot Rates. Just plug in your general preferences and let Hotwire choose matching hotels for as low as $88.

How much are Mississippi River packages?

Vacation packages to Mississippi River vary in price. They are priced per person and include discounted hotel and flight costs. With Hotwire, you can score a vacation package for as low as $576.

How to find cheap car rentals near Mississippi River?

Hotwire partners with some of the most reliable car rental companies in United States of America to bring you the best car rental deals in Mississippi River for as low as . Select a rental from Hotwire’s extensive inventory of cars for every travel style. If you plan on bringing friends or family along, opt for a spacious SUV. If you’re visiting on business but still plan to make time for off-the-clock adventures, Hotwire offers sleek luxury and convertible rentals.

Is it safe to travel to Mississippi River now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Mississippi River right now?” When it’s time to book your vacation, check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.

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