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Southern Illinois

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Cheap Flights to Southern Illinois

Fall in love at first flight with your vacation to Southern Illinois by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Southern Illinois on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Southern Illinois, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Southern Illinois

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Southern Illinois with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Southern Illinois?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Southern Illinois are in , but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Southern Illinois?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find  to choose from for your flight to Southern Illinois.

What airport is best to fly into Southern Illinois?

When you’re planning your trip to Southern Illinois, convenience is the name of the game. Luckily, Southern Illinois Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Southern Illinois must-do list.

How much are flights to Southern Illinois?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Southern Illinois on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as , you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Southern Illinois?

The trick to saving a stack of cash on your flight to Southern Illinois? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as  right now, why wait?

Southern Illinois Flight Information
Destination airport
Southern Illinois
Destination airport IATA code
MDH

Last Minute Hotel Deals in Southern Illinois

University Inn of Carbondale

University Inn of Carbondale

2.5 out of 5
2400 W Main St, Carbondale, IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the helpful staff ...
6.2/10 (254 reviews)
"Good service and helpful guidance by alex during the check in."

Reviewed on Aug 11, 2025

University Inn of Carbondale
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 out of 5
120 MUDDY MONSTER ROAD, Murphysboro, IL
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (462 reviews)
"Rooms were clean and comfy, great breakfast"

Reviewed on Aug 11, 2025

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Super 8 by Wyndham Carbondale

Super 8 by Wyndham Carbondale

2 out of 5
1180 E Main St, Carbondale, IL
Book a stay at this business-friendly motel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
"The staff was excellent. Very accommodating. Great price for a clean and comfortable stay. I stayed there 4 nights on a property / business trip. I was always happy returning to the room after a hard work day. Lowes is right behind the hotel. Not really close enough to walk, but the shortest drive. ..."

Reviewed on Aug 5, 2025

Super 8 by Wyndham Carbondale
Best Western Saluki Inn

Best Western Saluki Inn

2.5 out of 5
801 N Giant City Rd, Carbondale, IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.8/10 Good! (1,001 reviews)
"Cool"

Reviewed on Jun 30, 2025

Best Western Saluki Inn
Home2 Suites by Hilton Carbondale

Home2 Suites by Hilton Carbondale

3 out of 5
200 W Elm St, Carbondale, IL
Stay at this 3-star business-friendly hotel in Carbondale. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff and ...
8.6/10 Excellent! (478 reviews)
"Very clean, quite and excellent service"

Reviewed on Aug 9, 2025

Home2 Suites by Hilton Carbondale
Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG

3 out of 5
2300 Reed Station Parkway, Carbondale, IL
Stay at this 3-star business-friendly hotel in Carbondale. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in ...
8.6/10 Excellent! (593 reviews)
"Great staff"

Reviewed on Aug 13, 2025

Holiday Inn Carbondale-Conference Center by IHG
Quality Inn Carbondale University area

Quality Inn Carbondale University area

2.5 out of 5
1415 E Main St, Carbondale, IL
Stay at this hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
5.8/10 (811 reviews)
"It was really clean and nice looking on the inside."

Reviewed on Jun 7, 2025

Quality Inn Carbondale University area
Hampton Inn Carbondale

Hampton Inn Carbondale

2.5 out of 5
2175 Reed Station Pkwy, Carbondale, IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (572 reviews)
"Good place"

Reviewed on Jul 21, 2025

Hampton Inn Carbondale
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.