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Murphysboro

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Murphysboro Flights as Low as $368

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Wed, Jan 28 - Mon, Feb 2
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$368 Roundtrip, found 3 hours ago
$368
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Wed, Jan 28 from Harrisburg Intl. to Williamson County Regional, returning Mon, Feb 2, priced at $368 found 3 hours ago
United
Wed, Jan 28 - Mon, Feb 2
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$378 Roundtrip, found 3 hours ago
$378
Roundtrip
found 3 hours ago
Select United flight, departing Wed, Jan 28 from Harrisburg Intl. to Williamson County Regional, returning Mon, Feb 2, priced at $378 found 3 hours ago
United
Sun, Jan 25 - Sun, Feb 1
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$388 Roundtrip, found 4 hours ago
$388
Roundtrip
found 4 hours ago
Select United flight, departing Sun, Jan 25 from Harrisburg Intl. to Williamson County Regional, returning Sun, Feb 1, priced at $388 found 4 hours ago
United
Wed, Jan 28 - Mon, Feb 2
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$393 Roundtrip, found 3 days ago
$393
Roundtrip
found 3 days ago
Select United flight, departing Wed, Jan 28 from Harrisburg Intl. to Williamson County Regional, returning Mon, Feb 2, priced at $393 found 3 days ago
American Airlines
Thu, Jan 29 - Sat, Jan 31
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$397 Roundtrip, found 9 hours ago
$397
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Thu, Jan 29 from Harrisburg Intl. to Williamson County Regional, returning Sat, Jan 31, priced at $397 found 9 hours ago
United
Sun, Jan 25 - Sun, Feb 1
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$398 Roundtrip, found 4 hours ago
$398
Roundtrip
found 4 hours ago
Select United flight, departing Sun, Jan 25 from Harrisburg Intl. to Williamson County Regional, returning Sun, Feb 1, priced at $398 found 4 hours ago
United
Thu, Jan 29 - Sat, Jan 31
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$407 Roundtrip, found 9 hours ago
$407
Roundtrip
found 9 hours ago
Select United flight, departing Thu, Jan 29 from Harrisburg Intl. to Williamson County Regional, returning Sat, Jan 31, priced at $407 found 9 hours ago
American Airlines
Wed, Jan 28 - Mon, Feb 2
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$413 Roundtrip, found 2 days ago
$413
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jan 28 from Harrisburg Intl. to Williamson County Regional, returning Mon, Feb 2, priced at $413 found 2 days ago
American Airlines
Wed, Jan 28 - Mon, Feb 2
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$423 Roundtrip, found 3 hours ago
$423
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Wed, Jan 28 from Harrisburg Intl. to Williamson County Regional, returning Mon, Feb 2, priced at $423 found 3 hours ago
United
Thu, Jan 22 - Thu, Jan 29
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$426 Roundtrip, found 4 hours ago
$426
Roundtrip
found 4 hours ago
Select United flight, departing Thu, Jan 22 from Harrisburg Intl. to Williamson County Regional, returning Thu, Jan 29, priced at $426 found 4 hours ago
American Airlines
Mon, Jan 26 - Sat, Jan 31
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$433 Roundtrip, found 3 days ago
$433
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Jan 26 from Harrisburg Intl. to Williamson County Regional, returning Sat, Jan 31, priced at $433 found 3 days ago
United
Thu, Jan 29 - Sat, Jan 31
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$436 Roundtrip, found 3 days ago
$436
Roundtrip
found 3 days ago
Select United flight, departing Thu, Jan 29 from Harrisburg Intl. to Williamson County Regional, returning Sat, Jan 31, priced at $436 found 3 days ago
United
Thu, Jan 22 - Fri, Jan 30
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$436 Roundtrip, found 4 hours ago
$436
Roundtrip
found 4 hours ago
Select United flight, departing Thu, Jan 22 from Harrisburg Intl. to Williamson County Regional, returning Fri, Jan 30, priced at $436 found 4 hours ago
United
Wed, Jan 28 - Mon, Feb 2
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$443 Roundtrip, found 3 hours ago
$443
Roundtrip
found 3 hours ago
Select United flight, departing Wed, Jan 28 from Harrisburg Intl. to Williamson County Regional, returning Mon, Feb 2, priced at $443 found 3 hours ago
United
Sun, Jan 25 - Sun, Feb 1
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$446 Roundtrip, found 3 days ago
$446
Roundtrip
found 3 days ago
Select United flight, departing Sun, Jan 25 from Harrisburg Intl. to Williamson County Regional, returning Sun, Feb 1, priced at $446 found 3 days ago
United
Fri, Jan 30 - Sat, Jan 31
MDT
Harrisburg Intl.
MWA
Williamson County Regional
$446 Roundtrip, found 3 days ago
$446
Roundtrip
found 3 days ago
Select United flight, departing Fri, Jan 30 from Harrisburg Intl. to Williamson County Regional, returning Sat, Jan 31, priced at $446 found 3 days ago

Cheap Flights to Murphysboro

Fall in love at first flight with your vacation to Murphysboro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Murphysboro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Murphysboro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Murphysboro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Murphysboro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the MDH airport.

What is the cheapest month to fly to Murphysboro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Murphysboro are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Murphysboro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Murphysboro.

What airport is best to fly into Murphysboro?

When you’re planning your trip to Murphysboro, convenience is the name of the game. Luckily, Murphysboro Williamson County Regional Airport is nearby so you can deplane and get going on checking off everything on your Murphysboro must-do list.

How much are flights to Murphysboro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Murphysboro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $368, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Murphysboro?

The trick to saving a stack of cash on your flight to Murphysboro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $368 right now, why wait?

Murphysboro Flight Information
Destination airport
Williamson County Regional
Destination airport IATA code
MWA
Roundtrip price
$368

Last Minute Hotel Deals in Murphysboro

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 out of 5
120 MUDDY MONSTER ROAD Murphysboro IL
Book a stay at this business-friendly hotel in Murphysboro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.4/10 Exceptional! (503 reviews)
Always a great stay at holiday inn Express in murphysboro! The absolute best staff! They go out of their way to make sure you have a comfortable stay!

Reviewed on Nov 3, 2025

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Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Drury Inn & Suites Marion

Drury Inn & Suites Marion

3 out of 5
2706 W DeYoung St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,004 reviews)
Extremely friendly staff. Near shops and restaurants. Well worth the price. Food was good.

Reviewed on Nov 16, 2025

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Drury Inn & Suites Marion
Hampton Inn Carbondale

Hampton Inn Carbondale

2.5 out of 5
2175 Reed Station Pkwy Carbondale IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (606 reviews)
Parking not adequate need more handicap spaces..had a handicap room on 2nd floor had only handrail in slanted sides of tub Need hi rise toilet and handicap rails by toilet And walk in shower .non smoking room smelled musty no security door main floor missing locks not a seured facility. Will not ...

Reviewed on Nov 17, 2025

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Hampton Inn Carbondale
Baymont by Wyndham Marion

Baymont by Wyndham Marion

2.5 out of 5
2608 W Main St Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.2/10 Very Good! (1,062 reviews)
The room was spotless and the staff was great

Reviewed on Nov 23, 2025

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Baymont by Wyndham Marion
Country Inn & Suites by Radisson, Marion, IL

Country Inn & Suites by Radisson, Marion, IL

2.5 out of 5
1306 Halfway Road Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,000 reviews)
Yes

Reviewed on Nov 18, 2025

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Country Inn & Suites by Radisson, Marion, IL
Super 8 by Wyndham Carbondale

Super 8 by Wyndham Carbondale

2 out of 5
1180 E Main St Carbondale IL
Book a stay at this business-friendly motel in Carbondale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
NA didnt eat breakfast

Reviewed on Nov 16, 2025

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Super 8 by Wyndham Carbondale
Best Western Marion Hotel

Best Western Marion Hotel

2.5 out of 5
400 Comfort Dr Marion IL
Book a stay at this business-friendly hotel in Marion. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.2/10 Very Good! (1,006 reviews)
The room was well appointed, all necessities purposefully and neatly placed. Room is clean and comfortable. If you like a firm mattress, as I do, you'll find the beds comfortable. If I had anything that could have made our nights here more comfortable, I would say the a/c could be improved upon... ...

Reviewed on Nov 18, 2025

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Best Western Marion Hotel
Holiday Inn Carbondale-Conference Center by IHG

Holiday Inn Carbondale-Conference Center by IHG

3 out of 5
2300 Reed Station Parkway Carbondale IL
Book a stay at this business-friendly hotel in Carbondale. Enjoy free WiFi, free parking, and a 24-hour fitness center. Our guests praise the helpful staff in ...
8.6/10 Excellent! (633 reviews)
Fairly new facility, nice room. Very clean. Staff was very friendly. The only issue I had was that you can hear everything in these rooms. Through the door and the walls, in the hallway and neighboring rooms. Other than that we were very pleased!

Reviewed on Nov 16, 2025

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Holiday Inn Carbondale-Conference Center by IHG
See all 328 properties in Murphysboro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.