Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Otay Mesa Vacations

Pack those stellar shades. We have Otay Mesa vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Otay Mesa – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Otay Mesa vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Otay Mesa

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Otay Mesa vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Otay Mesa well.

Otay Mesa Flight + Hotel packages

Top Hotel Deals

See all 826 Hotels in Otay Mesa
Holiday Inn Express Hotel & Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa

2296 Niels Bohr Ct, San Diego
    2.5 out of 5.0
     
     

    Located in Otay Mesa, this hotel is within 6 mi (10 km) of U.S. Consulate General Tijuana, Autonomous University of Baja California Tijuana, and Aquatica. Mattress ...

    Holiday Inn Express Hotel & Suites San Diego Otay Mesa$95

    Holiday Inn Express Hotel & Suites San Diego Otay Mesa$95
    Quality Suites San Diego Otay Mesa

    Quality Suites San Diego Otay Mesa

    2351 Otay Center Dr, San Diego
      2.5 out of 5.0
       
       

      This hotel is in southern San Diego, within a mile of the Mexican border and Tijuana. Knott’s Soak City and Cricket Wireless Amphitheater are within six ...

      Quality Suites San Diego Otay Mesa$99

      Quality Suites San Diego Otay Mesa$99
      Town and Country San Diego

      Town and Country San Diego

      500 Hotel Circle North, San Diego
        3.5 out of 5.0
         
         

        Comprising 32 acres, this resort and conference center is next to the 27-hole Riverwalk Golf Club; Old Town, Balboa Park, SeaWorld San Diego, and the world famous ...

        Town and Country San Diego$80

        Town and Country San Diego$80
        Hard Rock Hotel San Diego

        Hard Rock Hotel San Diego

        207 5th Ave, San Diego
          4.0 out of 5.0
           
           

          The Hard Rock Hotel is in the center of San Diego's bustling Gaslamp Quarter, with restaurants, bars, and nightlife. The San Diego Convention Center is across ...

          Hard Rock Hotel San Diego$143

          Hard Rock Hotel San Diego$143
          Hilton San Diego Bayfront

          Hilton San Diego Bayfront

          1 Park Blvd, San Diego
            4.0 out of 5.0
             
             

            Rising 30 stories above San Diego Bay, this modern Hilton is adjacent to the San Diego Convention Center, across from Petco Park, and 3 blocks from the Gaslamp ...

            Hilton San Diego Bayfront$161

            Hilton San Diego Bayfront$161
            Best Western Plus Island Palms Hotel & Marina

            Best Western Plus Island Palms Hotel & Marina

            2051 Shelter Island Dr, San Diego
              3.0 out of 5.0
               
               

              This hotel is set on Shelter Island, surrounded by San Diego Bay and a private marina; Old Town is 5 miles away, and downtown San Diego is within 6 miles.

              Best Western Plus Island Palms Hotel & Marina$111

              Best Western Plus Island Palms Hotel & Marina$111
              Best Western Seven Seas

              Best Western Seven Seas

              411 Hotel Circle South, San Diego
                3.0 out of 5.0
                 
                 

                Adjacent to I-8, this budget-friendly hotel is within 6 miles of 2 sports stadiums, the Gaslamp Quarter, the convention center, the San Diego Zoo, SeaWorld, ...

                Best Western Seven Seas$71

                Best Western Seven Seas$71
                The Sofia Hotel

                The Sofia Hotel

                150 W Broadway, San Diego
                  3.5 out of 5.0
                   
                   

                  In the heart of downtown San Diego, this historic boutique hotel is 2 blocks from Horton Plaza, 4 blocks from the Gaslamp Quarter, and 6 blocks from the San ...

                  The Sofia Hotel$113

                  The Sofia Hotel$113
                  Wyndham Garden San Diego Near SeaWorld

                  Wyndham Garden San Diego Near SeaWorld

                  3737 Sports Arena Blvd, San Diego
                    3.0 out of 5.0
                     
                     

                    Located in San Diego, this family-friendly hotel is 1 mile from SeaWorld Adventure Park and 2 miles from Mission Beach. Belmont Park is 2.4 miles away.

                    Wyndham Garden San Diego Near SeaWorld$83

                    Wyndham Garden San Diego Near SeaWorld$83
                    Hilton San Diego Mission Valley

                    Hilton San Diego Mission Valley

                    901 Camino Del Rio S, San Diego
                      4.0 out of 5.0
                       
                       

                      This 14-story hotel is just off I-8, within a few minutes from Mission Valley malls, Balboa Park and Old Town San Diego; Qualcomm Stadium is just a 10-minute ...

                      Hilton San Diego Mission Valley$89

                      Hilton San Diego Mission Valley$89

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.