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Otay Mesa Vacation Packages

Otay Mesa Flight + Hotel packages

Paradise Point Resort & Spa
Westgate Hotel
Holiday Inn Express Mira Mesa-San Diego, an IHG Hotel
The Atwood
Urban Boutique Hotel
Fairmont Grand Del Mar
Humphreys Half Moon Inn
Ocean Beach Hotel

3-4 Night Vacations in Otay Mesa

The Westin San Diego Bayview
Kimpton Hotel Palomar San Diego, an IHG Hotel
The Dana on Mission Bay
Blue Sea Beach Hotel

5-7 Night Vacations in Otay Mesa

Paradise Point Resort & Spa
Westgate Hotel
Holiday Inn Express Mira Mesa-San Diego, an IHG Hotel
The Atwood

Cheap Hotel Deals in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA, 92154
The price is $139 per night from Aug 21 to Aug 22
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 out of 5
2351 Otay Center Dr, San Diego, CA, 92154
The price is $113 per night from Sep 5 to Sep 6
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Quality Suites San Diego Otay Mesa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA, 92101
The price is $186 per night from Sep 5 to Sep 6
Stay at this 4-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the restaurant and the clean ...
Wyndham San Diego Bayside

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Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA, 92101
The price is $225 per night from Aug 18 to Aug 19
Stay at this 4-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 6 restaurants. Our guests praise the helpful staff and the ...
Manchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA, 92101
The price is $219 per night from Sep 6 to Sep 7
Stay at this 4-star business-friendly aparthotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the clean ...
Hard Rock Hotel San Diego
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

2.5 out of 5
800 Bay Marina Dr, National City, CA, 91950
The price is $161 per night from Aug 21 to Aug 22
Stay at this business-friendly hotel in National City. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean rooms ...
Best Western Plus Marina Gateway Hotel
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd, San Diego, CA, 92109
The price is $269 per night from Sep 6 to Sep 7
Stay at this 4-star beach aparthotel in San Diego. Enjoy free WiFi, 5 outdoor pools, and 3 restaurants. Our guests praise the restaurant and the helpful staff ...
Paradise Point Resort & Spa
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA, 92109
The price is $289 per night from Sep 5 to Sep 6
Stay at this 4-star beach aparthotel in San Diego. Enjoy free WiFi, 2 restaurants, and a beach locale. Our guests praise the helpful staff and the clean rooms ...
San Diego Mission Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Alaska Airlines
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Frontier Airlines
United

Find cheap hotels in Otay Mesa

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Otay Mesa.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Otay Mesa’s 3772 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $113. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Otay Mesa hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Otay Mesa. No matter your reason for visiting Otay Mesa, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Otay Mesa hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Otay Mesa for as low as $113.

How many hotels are there in Otay Mesa?

With over 3772 hotels in Otay Mesa, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $113.

How to find cheap car rentals in Otay Mesa?

Finding a cheap car rental deal in San Diego is as easy as scoring cheap hotels in Otay Mesa. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Otay Mesa now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Otay Mesa right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.

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