Search Deals on
Otay Mesa Vacation Packages

Otay Mesa Flight + Hotel packages

Four Points by Sheraton San Diego Downtown Little Italy
Blue Sea Beach Hotel
Fairmont Grand Del Mar
InterContinental San Diego, an IHG Hotel
The Sofia Hotel
Pendry San Diego
Hotel Indigo Gaslamp Quarter, an IHG Hotel
The Westin San Diego Bayview

3-4 Night Vacations in Otay Mesa

Westin Carlsbad Resort & Spa
Blue Sea Beach Hotel
Fairmont Grand Del Mar
InterContinental San Diego, an IHG Hotel

5-7 Night Vacations in Otay Mesa

The Dana on Mission Bay
The Westin San Diego Bayview
Holiday Inn Express Mira Mesa-San Diego, an IHG Hotel
Country Inn & Suites by Radisson, San Diego North, CA

Cheap Hotel Deals in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA, 92154
The price is $154 per night from Jul 24 to Jul 25
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 out of 5
2351 Otay Center Dr, San Diego, CA, 92154
The price is $125 per night from Jul 12 to Jul 13
Stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Quality Suites San Diego Otay Mesa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA, 92101
The price is $203 per night from Jul 17 to Jul 18
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast. Our guests praise the restaurant and the clean rooms ...
Wyndham San Diego Bayside

You could be seeing lower prices

With member prices, you could save 10% or more right now on thousands of properties.
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA, 92101
The price is $214 per night from Jul 6 to Jul 7
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 6 restaurants. Our guests praise the helpful staff and the clean ...
Manchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA, 92101
The price is $219 per night from Jul 6 to Jul 7
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the clean ...
Hard Rock Hotel San Diego
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

3 out of 5
3737 Sports Arena Blvd, San Diego, CA, 92110
The price is $149 per night from Aug 1 to Aug 2
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
Wyndham Garden San Diego Near SeaWorld
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd, San Diego, CA, 92109
The price is $334 per night from Jul 17 to Jul 18
Stay at this 4-star beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and 3 restaurants. Our guests praise the restaurant and the helpful staff in ...
Paradise Point Resort & Spa
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S, San Diego, CA, 92108
The price is $144 per night from Aug 1 to Aug 2
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and onsite parking. Our guests praise the helpful staff and the ...
Days Inn by Wyndham San Diego Hotel Circle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Alaska Airlines
Spirit Airlines
Delta
Spirit Airlines

Find cheap hotels in Otay Mesa

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Otay Mesa hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Otay Mesa.

Choosing the right hotel in California has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Otay Mesa’s 3830 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $125. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Otay Mesa hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Otay Mesa. No matter your reason for visiting Otay Mesa, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Otay Mesa hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Otay Mesa for as low as $125.

How many hotels are there in Otay Mesa?

With over 3830 hotels in Otay Mesa, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $125.

How to find cheap car rentals in Otay Mesa?

Finding a cheap car rental deal in San Diego is as easy as scoring cheap hotels in Otay Mesa. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Otay Mesa now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Otay Mesa right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.