Search for Cheap Deals on
Hotels in Vandalia

Choose from 58 Vandalia Hotel Deals

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (659 reviews)
Nice staff, comfortable bed, good breakfast. Not enough towels in the room, broken microwave.

Reviewed on Nov 29, 2025

Comfort Inn & Suites - Hannibal
Knights Inn New Florence

Knights Inn New Florence

2 out of 5
Booneslick Road, 403, 403 New Florence MO
  • 2 hours drive from Mississippi River
Stay at this hotel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Stone Hill Winery and Graham Cave State Park are located ...
6.8/10 (533 reviews)
Room was clean. Staff was courteous.

Reviewed on Nov 7, 2025

Knights Inn New Florence
Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 out of 5
3602 S Clark St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (483 reviews)
The reservation system was down when we arrived but the front desk manager was a pro in getting our information and into our room while he worked through processing out payment. AWESOMENESS!

Reviewed on Dec 4, 2025

Best Western Teal Lake Inn
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions West ...
7.4/10 Good! (215 reviews)
Great

Reviewed on Nov 28, 2025

Days Inn by Wyndham Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.2/10 (733 reviews)
Very clean room. Not too many other guests there.

Reviewed on Nov 29, 2025

Baymont by Wyndham Hannibal
Days Inn by Wyndham Mexico

Days Inn by Wyndham Mexico

2 out of 5
2902 S. Clark Mexico MO
  • 1 hour drive from Mississippi River
Stay at this hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Green Estates and Lakeview Park are located nearby.
6.8/10 (296 reviews)
Room was clean. Was not a lot of noise. There was construction going on in there entry way.

Reviewed on Nov 16, 2025

Days Inn by Wyndham Mexico
Super 8 by Wyndham Bowling Green

Super 8 by Wyndham Bowling Green

2 out of 5
1216 E Champ Clark Dr Bowling Green MO
  • 36 min drive from Mississippi River
Stay at this hotel in Bowling Green. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
8.2/10 Very Good! (480 reviews)
I didn’t comment on breakfast because I didn’t eat breakfast. The staff were very nice. Ibwill be staying there again.

Reviewed on Dec 12, 2025

Super 8 by Wyndham Bowling Green
Cannon Dam Cabins

Cannon Dam Cabins

3 out of 5
42526 Cabin Rd Perry MO
  • 23 min drive from Mississippi River
Stay at this cabin in Perry. Enjoy free WiFi, a picnic area, and patios. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
9/10 Wonderful! (13 reviews)
Easy to get too and from, but had to leave early to avoid a snow storm.

Reviewed on Nov 29, 2025

Cannon Dam Cabins
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.2/10 Good! (152 reviews)
The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three ...

Reviewed on Dec 7, 2025

Howard Johnson BY Wyndham Hannibal
The Junction Inn

The Junction Inn

2 out of 5
28804 MO-19 Perry MO
  • 26 min drive from Mississippi River
Stay at this hotel in Perry. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Bill Trower Memorial Park and Perry Park are located ...
6.4/10 (37 reviews)
The room clean and the staff was courteous.

Reviewed on Oct 29, 2025

The Junction Inn
Kennedys Red Barn Inn

Kennedys Red Barn Inn

2.5 out of 5
22748 Joanna Dr Perry MO
  • 23 min drive from Mississippi River
Stay at this B&B in Perry. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
9.4/10 Exceptional! (21 reviews)
I am going to start with the hosts. They make the place. The couple are amazing. Very friendly and kind. They work to give a good service and they exceed that. The breakfast has variety and adding hand made apple sauce(very delicious).They offered me different type of milks for my coffee. They also ...

Reviewed on Oct 27, 2025

Kennedys Red Barn Inn
Garth Woodside Mansion B&B

Garth Woodside Mansion B&B

4 out of 5
11069 New London Gravel Rd Hannibal MO
  • 25 min drive from Mississippi River
Stay at this B&B in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Bear Creek Park and West Ely Park are located nearby.
9.6/10 Exceptional! (21 reviews)
Garth Mansion is Perfect
The Mansion is spectacular, our room was perfect and the on suite bathroom/shower, fireplace bed, everything was and is fantastic. The staff and the other guests were so friendly they felt like family.

Reviewed on Oct 17, 2025

Garth Woodside Mansion B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Vandalia

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Vandalia hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Vandalia.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Vandalia’s 58 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $67. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Vandalia hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Vandalia. No matter your reason for visiting Vandalia, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Vandalia hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Vandalia for as low as $67.

How many hotels are there in Vandalia?

With over 58 hotels in Vandalia, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $67.

How to find cheap car rentals in Vandalia?

Finding a cheap car rental deal in Vandalia is as easy as scoring cheap hotels in Vandalia. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.