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Choose from 66 Vandalia Hotel Deals

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (704 reviews)
"Clean room, good hot breakfast, pool and hot tub were open until 11pm. Quite place. Our beds were comfortable. Great place to stay. Highly recommended."

Reviewed on Jun 9, 2026

Comfort Inn & Suites - Hannibal
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions West ...
7.4/10 Good! (250 reviews)
"We were looking forward to using the outdoor pool advertised, but it was out of use."

Reviewed on Jun 8, 2026

Days Inn by Wyndham Hannibal
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

2.5 out of 5
4141 Market St Hannibal MO
  • 27 min drive from Mississippi River
Book a stay at this family-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
6.4/10 (774 reviews)
"This property was nice. There was construction going on but it didn't bother me. The room was way better than any other that I got that price"

Reviewed on Jun 14, 2026

Baymont by Wyndham Hannibal
Cannon Dam Cabins

Cannon Dam Cabins

3 out of 5
42526 Cabin Rd Perry MO
  • 23 min drive from Mississippi River
Stay at this cabin in Perry. Enjoy free WiFi, laundry facilities, and a picnic area. Popular attractions Robert E Allen Recreation Area and Perry Park are located ...
9/10 Wonderful! (18 reviews)
"Nice quiet location. Friendly staff. Rugs were dated, but clean. Bathroom fan very loud. Toilet too close to wall. Use the website to book, not Expedia, as they charged fifteen more."

Reviewed on May 13, 2026

Cannon Dam Cabins
Knights Inn New Florence

Knights Inn New Florence

2 out of 5
Booneslick Road, 403, 403 New Florence MO
  • 2 hours drive from Mississippi River
Stay at this hotel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Curling Vine Winery and Stone Hill Winery are located ...
7/10 Good! (569 reviews)
"This place was terrible. Looked like it remodeled that ran out of money. It seems like they're trying to remodel but nothing was really being done. Our bed had a dirty blanket on top of it... what I mean dirty it had crusties. When I turned it in at the front desk for a clean one, no apologies. nada, ..."

Reviewed on Jun 10, 2026

Knights Inn New Florence
Best Western Teal Lake Inn

Best Western Teal Lake Inn

2.5 out of 5
3602 S Clark St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (520 reviews)
"We had issues with the wifi. The wifi was down the first night and then the password capitalization was wrong on the documentation. Also needs to be noted there isn't an elevator. The room was great! It was clean and mattress was the best I've had in a hotel."

Reviewed on May 17, 2026

Best Western Teal Lake Inn
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

2 out of 5
4141B MARKET ST Hannibal MO
  • 27 min drive from Mississippi River
Stay at this hotel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (168 reviews)
"The staff was very accommodating to my disability needs. They were cleaning constantly."

Reviewed on May 18, 2026

Howard Johnson BY Wyndham Hannibal
The Junction Inn

The Junction Inn

2 out of 5
28804 MO-19 Perry MO
  • 26 min drive from Mississippi River
Stay at this hotel in Perry. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Bill Trower Memorial Park and Perry Park are located ...
6.4/10 (39 reviews)
"We stayed for 3 nights. No coffee unless you go next door to the gas station also no ice machines you also had to go to the gas station. No one at counter when checking out."

Reviewed on May 17, 2026

The Junction Inn
Days Inn by Wyndham Mexico

Days Inn by Wyndham Mexico

2 out of 5
2902 S. Clark Mexico MO
  • 1 hour drive from Mississippi River
Stay at this hotel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Green Estates and Lakeview Park are located nearby.
7/10 Good! (306 reviews)
"The shower curtain rod was very loosely attached to the walls. This caused the rod to droop so much that I was stepping on the bottom of the curtain while showering."

Reviewed on Jun 12, 2026

Days Inn by Wyndham Mexico
Super 8 by Wyndham Bowling Green

Super 8 by Wyndham Bowling Green

2 out of 5
1216 E Champ Clark Dr Bowling Green MO
  • 36 min drive from Mississippi River
Stay at this hotel in Bowling Green. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our ...
8.4/10 Very Good! (496 reviews)
"Very nice hot breakfast and cold selection if you prefer"

Reviewed on Jun 8, 2026

Super 8 by Wyndham Bowling Green
Budget Inn Mexico MO on US 54

Budget Inn Mexico MO on US 54

2 out of 5
1010 E Liberty St Mexico MO
  • 1 hour drive from Mississippi River
Book a stay at this business-friendly motel in Mexico. Enjoy free breakfast, free WiFi, and free parking. Popular attractions MLK Jr. Park and Garfield Park ...
7/10 Good! (112 reviews)
"NOTHING"

Reviewed on Apr 15, 2026

Budget Inn Mexico MO on US 54
Brady Hotel

Brady Hotel

2 out of 5
202 Clark Dr New Florence MO
  • 2 hours drive from Mississippi River
Stay at this motel in New Florence. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Curling Vine Winery and Stone Hill Winery are located ...
Brady Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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