Search for Cheap Deals on
Hotels in Palmyra

Choose from 176 Palmyra Hotel Deals

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

2.5 out of 5
120 Lindsey Drive Hannibal MO
  • 16 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8/10 Very Good! (1,010 reviews)
"It is a great older building. Very spacious. Toilet needed fixing before we settled in, no shampoo, electrical plugs were few and some not working. We didn’t get everything charged for the next day. Breakfast was good. Staff were friendly."

Reviewed on Jun 10, 2026

Quality Inn & Suites Hannibal West
Best Western On The River

Best Western On The River

2.5 out of 5
401 North 3rd Street Hannibal MO
  • 19 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,010 reviews)
"Staff was very friendly and welcoming."

Reviewed on Jun 9, 2026

Best Western On The River
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 out of 5
4000 Market St Hannibal MO
  • 21 min drive from Gardner House Museum
Book a stay at this spa hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
7.6/10 Good! (704 reviews)
"Clean room, good hot breakfast, pool and hot tub were open until 11pm. Quite place. Our beds were comfortable. Great place to stay. Highly recommended."

Reviewed on Jun 9, 2026

Comfort Inn & Suites - Hannibal
Stoney Creek Inn Quincy

Stoney Creek Inn Quincy

2 out of 5
3809 Broadway St Quincy IL
  • 28 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Quincy. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.6/10 Excellent! (1,001 reviews)
"I have stayed here in the past, but it has been a few years. It definitely is showing its age a bit and it looks like some of the maintenance is a little lacking."

Reviewed on Jun 9, 2026

Stoney Creek Inn Quincy
Heritage Hotel Quincy

Heritage Hotel Quincy

2 out of 5
300 Gardner Expy Quincy IL
  • 24 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Quincy. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Villa Kathrine and Villa Katherine ...
8.8/10 Excellent! (375 reviews)
"Rooms were comfortable staff was great"

Reviewed on Jun 9, 2026

Heritage Hotel Quincy
Oak Hill Inn & Suites

Oak Hill Inn & Suites

2.5 out of 5
1701 Oak St Canton MO
  • 55 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Canton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (967 reviews)
"Breakfast was good, room was clean, and staff was nice!"

Reviewed on Jun 8, 2026

Oak Hill Inn & Suites
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 out of 5
105 Lakeside Dr Hannibal MO
  • 16 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,001 reviews)
"This hotel has one of the best breakfast options of any hotel we’ve stayed at. It is a nice and clean property. Our go to hotel when staying in Hannibal!"

Reviewed on Jun 7, 2026

Sleep Inn & Suites Hannibal West
Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area

2.5 out of 5
200 S 3rd St Quincy IL
  • 25 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Quincy. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.6/10 Good! (1,004 reviews)
"Easy to find location on west side of Quincy."

Reviewed on Jun 6, 2026

Microtel Inn & Suites by Wyndham Quincy Downtown/River Area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2 out of 5
123 Huckleberry Heights Dr Hannibal MO
  • 19 min drive from Gardner House Museum
Stay at this motel in Hannibal. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.4/10 Good! (1,006 reviews)
"There was blood on the bathroom wall. It was okay for a less than a 24 hr stay for a truck pickup."

Reviewed on Jun 8, 2026

Motel 6 Hannibal, MO
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2 out of 5
4070 Market St Hannibal MO
  • 21 min drive from Gardner House Museum
Stay at this hotel in Hannibal. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions West ...
7.4/10 Good! (250 reviews)
"We were looking forward to using the outdoor pool advertised, but it was out of use."

Reviewed on Jun 8, 2026

Days Inn by Wyndham Hannibal
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

3 out of 5
4821 Oak St Quincy IL
  • 29 min drive from Gardner House Museum
Book a stay at this spa hotel in Quincy. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (654 reviews)
"Staff is very professional and helpful, rooms were super clean and food at the restaurant was top-notch!"

Reviewed on Jun 8, 2026

Holiday Inn Quincy East by IHG
Town & Country Inn and Suites

Town & Country Inn and Suites

2.5 out of 5
110 N 54th St Quincy IL
  • 29 min drive from Gardner House Museum
Book a stay at this business-friendly hotel in Quincy. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
9.2/10 Wonderful! (925 reviews)
"The hotel was clean, rooms a tad dated, the staff was nice, it was quiet, parking was ample. breakfast was so so. The hot tub did not work. And the room was very warm and humid at times, seems like the air conditioners were older and couldn't keep up."

Reviewed on Jun 9, 2026

Town & Country Inn and Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Palmyra

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Palmyra hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Palmyra.

Choosing the right hotel in Missouri has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Palmyra’s 176 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $62. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Palmyra hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Palmyra. No matter your reason for visiting Palmyra, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Palmyra hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can unlock great deals on your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Palmyra for as low as $62.

How many hotels are there in Palmyra?

With over 176 hotels in Palmyra, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $62.

How to find cheap car rentals in Palmyra?

Finding a cheap car rental deal in Palmyra is as easy as scoring cheap hotels in Palmyra. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.