Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Panhandle Vacations

Pack those stellar shades. We have Panhandle vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Panhandle – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Panhandle vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Panhandle

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Panhandle vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Panhandle well.

Top Hotel Deals

See all 101 Hotels in Panhandle
Executive Inn

Executive Inn

9680 I-40 Frontage Road, Panhandle
     
     

    Situated in Panhandle, this motel is close to VW Slug Bug Ranch. Regional attractions also include Square House Museum.

    Amarillo Inn & Suites

    Amarillo Inn & Suites

    1911 I-40 East, Amarillo
      3.0 out of 5.0
       
       

      Located in the heart of Amarillo, this hotel is within 1 mi (2 km) of American Quarter Horse Association and American Quarter Horse Hall of Fame. Amarillo Museum ...

      Days Inn Amarillo East

      Days Inn Amarillo East

      1701 I-40E, Amarillo
        2.0 out of 5.0
         
         

        Situated in Amarillo, this hotel is within 1 mi (2 km) of American Quarter Horse Association and American Quarter Horse Hall of Fame. Amarillo Museum of Art ...

        Sleep Inn & Suites West Medical Center

        Sleep Inn & Suites West Medical Center

        6915 I-40 W, Amarillo
          2.5 out of 5.0
           
           

          Located in the heart of Amarillo, this hotel is 0.6 mi (1 km) from Westgate Mall and 1.5 mi (2.5 km) from Don Harrington Discovery Center. Don and Sybil Harrington ...

          Baymont Inn & Suites Amarillo West

          Baymont Inn & Suites Amarillo West

          3411 I-40 W, Amarillo
            2.5 out of 5.0
             
             

            Situated in Amarillo, this hotel is 0.7 mi (1.1 km) from Amarillo Little Theatre and within 3 mi (5 km) of Amarillo Museum of Art and Don Harrington Discovery ...

            Holiday Inn Express Hotel & Suites Amarillo West

            Holiday Inn Express Hotel & Suites Amarillo West

            8330 W Amarillo Blvd, Amarillo
              2.5 out of 5.0
               
               

              Situated near the airport, this hotel is 0.9 mi (1.4 km) from Don and Sybil Harrington Cancer Center and 1.4 mi (2.2 km) from Don Harrington Discovery Center. ...

              Fifth Season Inn

              Fifth Season Inn

              6801 W Interstate 40, Amarillo
                3.0 out of 5.0
                 
                 

                Situated in Amarillo, this hotel is 0.7 mi (1.1 km) from Westgate Mall and 1.6 mi (2.5 km) from Don Harrington Discovery Center. Don and Sybil Harrington Cancer ...

                La Quinta Inn Amarillo West/Medical Center

                La Quinta Inn Amarillo West/Medical Center

                2108 Coulter Dr, Amarillo
                  2.5 out of 5.0
                   
                   

                  Situated in Amarillo, this hotel is within 1 mi (2 km) of Westgate Mall and Don Harrington Discovery Center. Don and Sybil Harrington Cancer Center and Baptist ...

                  Microtel Inn & Suites by Wyndham Amarillo

                  Microtel Inn & Suites by Wyndham Amarillo

                  1501 Ross St, Amarillo
                    2.0 out of 5.0
                     
                     

                    Situated in the business district, this hotel is within 1 mi (2 km) of American Quarter Horse Association and American Quarter Horse Hall of Fame. Amarillo Museum ...

                    My Place Hotel-Amarillo West/ Medical Center, TX

                    My Place Hotel-Amarillo West/ Medical Center, TX

                    2208 Cinema Drive, Amarillo
                      2.5 out of 5.0
                       
                       

                      Situated in Amarillo, this hotel is 1 mi (1.6 km) from Westgate Mall and within 3 mi (5 km) of Don Harrington Discovery Center and Cadillac Ranch. Don and Sybil ...

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.