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Mission District Vacations

Pack those stellar shades. We have Mission District vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Mission District – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Mission District vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Mission District

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Mission District vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Mission District well.

Mission District Flight + Hotel packages

Top Hotel Deals

See all 699 Hotels in Mission District
El Capitan Hotel

El Capitan Hotel

2361 Mission St, San Francisco
    2.0 out of 5.0
     
     

    Located in Mission District, this hotel is within 2 mi (3 km) of Castro Theatre, Louise Davies Symphony Hall, and Asian Art Museum of San Francisco. Twin Peaks ...

    Hotel Sunrise

    Hotel Sunrise

    447 Valencia St, San Francisco
      2.0 out of 5.0
       
       

      This hotel is located in San Francisco (Mission District), close to Mission San Francisco de Asís, University of San Francisco, and Twin Peaks. Also nearby are ...

      Hotel Sunrise$89

      Hotel Sunrise$89
      Parker Guest House

      Parker Guest House

      520 Church Street, San Francisco
         
         

        Located in Castro District, this bed & breakfast is within 2 mi (3 km) of Castro Theatre, Louise Davies Symphony Hall, and Asian Art Museum of San Francisco. ...

        Union Hotel

        Union Hotel

        2030 Mission St, San Francisco
          2.0 out of 5.0
           
           

          Located in Mission District, this hotel is within 1 mi (2 km) of Castro Theatre, Louise Davies Symphony Hall, and Asian Art Museum of San Francisco. University ...

          Noe's Nest Bed and Breakfast

          Noe's Nest Bed and Breakfast

          1257 Guerrero St., San Francisco
            3.5 out of 5.0
             
             

            Located in Mission District, this bed & breakfast is within 3 mi (5 km) of Castro Theatre, Twin Peaks, and University of California San Francisco. Louise Davies ...

            Inn San Francisco

            Inn San Francisco

            943 South Van Ness Avenue, San Francisco
              2.5 out of 5.0
               
               

              Located in Mission District, this bed & breakfast is within 2 mi (3 km) of Castro Theatre, Louise Davies Symphony Hall, and Asian Art Museum of San Francisco. ...

              Hotel Tropica

              Hotel Tropica

              663 Valencia St, San Francisco
                2.0 out of 5.0
                 
                 

                Located in Mission District, this hotel is within 1 mi (2 km) of Castro Theatre and Louise Davies Symphony Hall. Asian Art Museum of San Francisco and Westfield ...

                Hotel Nikko San Francisco

                Hotel Nikko San Francisco

                222 Mason St, San Francisco
                  4.0 out of 5.0
                   
                   

                  The Asian-inspired Hotel Nikko San Francisco is located downtown, a 4-minute walk from Union Square and the designer shops of Westfield San Francisco Centre. ...

                  Hotel Nikko San Francisco$166

                  Hotel Nikko San Francisco$166
                  The Westin St. Francis San Francisco on Union Square

                  The Westin St. Francis San Francisco on Union Square

                  335 Powell Street, San Francisco
                    4.0 out of 5.0
                     
                     

                    This elegant and historic 1904 hotel offers a prime location across from San Francisco's Union Square; cable cars stop right at the front door, and the Financial ...

                    The Westin St. Francis San Francisco on Union Square$134

                    The Westin St. Francis San Francisco on Union Square$134
                    San Francisco Marriott Marquis

                    San Francisco Marriott Marquis

                    780 Mission Street, San Francisco
                      4.0 out of 5.0
                       
                       

                      The San Francisco Marriott Marquis is steps from Union Square shopping, Chinatown, cable cars, and the San Francisco Museum of Modern Art.

                      San Francisco Marriott Marquis$169

                      San Francisco Marriott Marquis$169

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.