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Hotels in Melrose

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Choose from 929 Melrose Hotel Deals

Drury Inn & Suites Gainesville

Drury Inn & Suites Gainesville

3 out of 5
4000 Southwest 40th Blvd Gainesville FL
  • 22 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Drury Inn & Suites Gainesville
Country Inn & Suites by Radisson, Gainesville, FL

Country Inn & Suites by Radisson, Gainesville, FL

3 out of 5
4015 Sw 43rd St Gainesville FL
  • 23 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (2,035 reviews)
"Breakfast"

Reviewed on Nov 13, 2026

Country Inn & Suites by Radisson, Gainesville, FL
Sleep Inn & Suites University/Shands

Sleep Inn & Suites University/Shands

2.5 out of 5
4110 SW 40th Boulevard Gainesville FL
  • 23 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Sleep Inn & Suites University/Shands
Hotel Eleo at the University of Florida

Hotel Eleo at the University of Florida

3 out of 5
1514 Southwest 14th Street Gainesville FL
  • 19 min drive from Santa Fe Lake
Stay at this hotel in Gainesville. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the restaurant and the helpful staff in our ...
9.4/10 Exceptional! (1,317 reviews)
"i loved the hotel and everything about it, i just wish i did not have to valet . there should be an option"

Reviewed on Nov 12, 2026

Hotel Eleo at the University of Florida
Hyatt Place Gainesville Downtown

Hyatt Place Gainesville Downtown

3 out of 5
212 SE 1ST STREET, Gainesville FL
  • 17 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Hyatt Place Gainesville Downtown
Hotel Indigo Gainesville-Celebration Pointe by IHG

Hotel Indigo Gainesville-Celebration Pointe by IHG

3.5 out of 5
5020 SW 30th Lane Gainesville FL
  • 21 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. ...
9.2/10 Wonderful! (1,062 reviews)
"Very good location and clean room"

Reviewed on Nov 12, 2026

Hotel Indigo Gainesville-Celebration Pointe by IHG
Comfort Suites Gainesville near University

Comfort Suites Gainesville near University

2.5 out of 5
2603 SW 13TH STREET Gainesville FL
  • 20 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
9.2/10 Wonderful! (1,565 reviews)
"The rooms were clean and neat with updated appliances. Rooms also equipped with various phone hookups."

Reviewed on Nov 10, 2026

Comfort Suites Gainesville near University
Days Inn by Wyndham Gainesville Hospital/University Area

Days Inn by Wyndham Gainesville Hospital/University Area

2.5 out of 5
2649 Sw 13th St Gainesville FL
  • 20 min drive from Santa Fe Lake
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Ben Hill Griffin Stadium and Bivens Arm Nature ...
Days Inn by Wyndham Gainesville Hospital/University Area
Red Roof Inn PLUS+ Gainesville

Red Roof Inn PLUS+ Gainesville

2.5 out of 5
3500 Southwest 42nd St Gainesville FL
  • 22 min drive from Santa Fe Lake
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Red Roof Inn PLUS+ Gainesville
HOM Hotel Gainesville, SureStay Collection by Best Western

HOM Hotel Gainesville, SureStay Collection by Best Western

2.5 out of 5
3905 Sw 43Rd St Gainesville FL
  • 22 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
HOM Hotel Gainesville, SureStay Collection by Best Western
DoubleTree by Hilton Gainesville

DoubleTree by Hilton Gainesville

4 out of 5
3726 Sw 40th Blvd Gainesville FL
  • 22 min drive from Santa Fe Lake
Stay at this hotel in Gainesville. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. ...
DoubleTree by Hilton Gainesville
Comfort Inn Gainesville - University Area

Comfort Inn Gainesville - University Area

2.5 out of 5
3440 SW 40th Blvd Gainesville FL
  • 22 min drive from Santa Fe Lake
Book a stay at this business-friendly hotel in Gainesville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,080 reviews)
"The property is very outdated. The tv in our room was so old that I don’t even think it had smart tv capabilities. My feet were dirty from the carpet/flooring in our room. However, the staff were extremely helpful and friendly! Free popcorn and cookies in the lobby :)"

Reviewed on Nov 10, 2026

Comfort Inn Gainesville - University Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Melrose

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Choosing the right hotel in Florida has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Melrose’s 929 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $59. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Melrose hotel deals at the last minute.

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Frequently Asked Questions About Melrose hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Melrose?

With over 929 hotels in Melrose, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $59.

How to find cheap car rentals in Melrose?

Finding a cheap car rental deal in Melrose is as easy as scoring cheap hotels in Melrose. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.