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Hotels in Mainz City Center

Choose from 1264 Mainz City Center Hotel Deals

Leonardo Hotel Mainz

Leonardo Hotel Mainz

Augustusstrasse 6 Mainz RP
  • 15 min walk from Mainz Cathedral
Stay at this hotel in Mainz. Enjoy breakfast (surcharge), 24-hour room service, and a fitness center. Our guests praise the helpful staff in our reviews. Popular ...
8.4/10 Very Good! (886 reviews)
"Staff seemed put out by having to do their job of checking us in, the concept of hospitality was not in their vocabulary. Housekeeping left our soap contact empty, left dirty cups and upon asking for soap and clean towels, nothing happened until I asked again. A sauna and pool are adventure but the ..."

Reviewed on May 18, 2026

Leonardo Hotel Mainz
Hilton Mainz

Hilton Mainz

Rheinstrasse 68 Mainz
  • 6 min walk from Mainz Cathedral
Book a stay at this luxury hotel in Mainz. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular ...
8.6/10 Excellent! (445 reviews)
"Room was very smelly i requested cleaning fist night sheets looked clean but there was a nasty smell carpet was so colorful that didn’t show how clean it was Breakfast was great staff were nice I am disappointed with Hilton"

Reviewed on May 5, 2026

Hilton Mainz
Hyatt Regency Mainz

Hyatt Regency Mainz

Templerstraße 6 Mainz
  • 11 min walk from Mainz Cathedral
Book a stay at this luxury hotel in Mainz. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (780 reviews)
"The staff were very professional and polite. We had 2 rooms, and we were very pleased with the space and how comfortable the beds were. Definitely a must to visit again."

Reviewed on Apr 26, 2026

Hyatt Regency Mainz
Sheraton Frankfurt Airport Hotel & Conference Center

Sheraton Frankfurt Airport Hotel & Conference Center

Flughafen Terminal 1 Frankfurt HE
  • 49 min drive from Mainz Cathedral
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...
8.6/10 Excellent! (2,996 reviews)
"The hotel staff assigned me room#9108, which was a long walk with the luggages, that was unacceptable.."

Reviewed on May 18, 2026

Sheraton Frankfurt Airport Hotel & Conference Center
Hyatt Place Frankfurt Airport

Hyatt Place Frankfurt Airport

De-Saint-Exupéry-Straße 4 Frankfurt HE
  • 53 min drive from Mainz Cathedral
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast and the ...
9.2/10 Wonderful! (2,255 reviews)
"Room was very comfortable, slept like a baby. Food was better than expected even for a overnight stay."

Reviewed on May 16, 2026

Hyatt Place Frankfurt Airport
Scandic Frankfurt Museumsufer

Scandic Frankfurt Museumsufer

Wilhelm-Leuschner-Straße 44 Frankfurt HE
  • 1 hour drive from Mainz Cathedral
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the breakfast ...
9/10 Wonderful! (1,186 reviews)
"-"

Reviewed on May 18, 2026

Scandic Frankfurt Museumsufer
Hilton Garden Inn Frankfurt Airport

Hilton Garden Inn Frankfurt Airport

The Squaire Frankfurt
  • 49 min drive from Mainz Cathedral
Book a stay at this spa hotel in Frankfurt. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff ...
8.8/10 Excellent! (2,760 reviews)
"Hugely convenient location, great property, easy to book via overnight layovers."

Reviewed on May 18, 2026

Hilton Garden Inn Frankfurt Airport
IntercityHotel Frankfurt Hauptbahnhof Süd

IntercityHotel Frankfurt Hauptbahnhof Süd

Mannheimer Str. 21 Frankfurt HE
  • 1 hour drive from Mainz Cathedral
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
8.8/10 Excellent! (1,459 reviews)
"とても良い"

Reviewed on May 18, 2026

IntercityHotel Frankfurt Hauptbahnhof Süd
Hampton by Hilton Frankfurt Airport

Hampton by Hilton Frankfurt Airport

Thea-Rasche, 6 Frankfurt
  • 52 min drive from Mainz Cathedral
Book a stay at this business-friendly hotel in Frankfurt. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,437 reviews)
"Great Hotel Staff very helpful nice bar and Coffee shop Thanks"

Reviewed on May 18, 2026

Hampton by Hilton Frankfurt Airport
Staycity Aparthotels, Frankfurt Airport

Staycity Aparthotels, Frankfurt Airport

Amelia-Mary-Earhart-Straße 9 Frankfurt
  • 53 min drive from Mainz Cathedral
Stay at this hotel in Frankfurt. Enjoy free WiFi, breakfast (surcharge), and a fitness center. Our guests praise the helpful staff and the clean rooms in our ...
9/10 Wonderful! (1,180 reviews)
"Great service"

Reviewed on May 15, 2026

Staycity Aparthotels, Frankfurt Airport
Maritim Hotel Frankfurt

Maritim Hotel Frankfurt

Theodor-Heuss-Allee 3 Frankfurt HE
  • 1 hour drive from Mainz Cathedral
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (1,003 reviews)
"Room cool, great pool and gym needed universal gym"

Reviewed on May 14, 2026

Maritim Hotel Frankfurt
Steigenberger Airport Hotel Frankfurt

Steigenberger Airport Hotel Frankfurt

Unterschweinstiege 16 Frankfurt HE
  • 52 min drive from Mainz Cathedral
Book a stay at this luxury hotel in Frankfurt. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the breakfast and the restaurant in ...
8.8/10 Excellent! (2,281 reviews)
"I paid for two nights and their hotel, but they charged me for three nights. Avoid them."

Reviewed on May 17, 2026

Steigenberger Airport Hotel Frankfurt
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Mainz City Center

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For you, intrepid voyager, Hotwire has a large selection of the best hotels in Mainz City Center.

Choosing the right hotel in Rhineland-Palatinate has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Mainz City Center’s 1,264 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $80. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Mainz City Center hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Mainz City Center. No matter your reason for visiting Mainz City Center, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Mainz City Center hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Mainz City Center?

With over 1,264 hotels in Mainz City Center, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $80.

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Finding a cheap car rental deal in Mainz City Center is as easy as scoring cheap hotels in Mainz City Center. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.