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Hotels in Defiance

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Choose from 725 Defiance Hotel Deals

Hilton Garden Inn Toledo Downtown

Hilton Garden Inn Toledo Downtown

3 out of 5
101 N Summit St Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Toledo. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
9/10 Wonderful! (1,185 reviews)
The room was very clean! The staff was very friendly! The venue that we were attending was attached to the hotel which made it really nice because we didn't have to take our coats to the concert. The lobby bar was really cool! And the option of having a continental breakfast for a additional amount ...

Reviewed on Nov 23, 2025

Hilton Garden Inn Toledo Downtown
Country Inn & Suites by Radisson, Rossford - Toledo South

Country Inn & Suites by Radisson, Rossford - Toledo South

3 out of 5
9790 Clark Drive Perrysburg OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Perrysburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.2/10 Very Good! (1,348 reviews)
Friendly staff at check in. Clean and spacious room.

Reviewed on Nov 27, 2025

Country Inn & Suites by Radisson, Rossford - Toledo South
Red Roof Inn Toledo - University

Red Roof Inn Toledo - University

2 out of 5
3530 Executive Parkway Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Stay at this hotel in Toledo. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
6.8/10 (1,002 reviews)
Yes. I was surrounded by genuine hospitable people. The room was clean, quiet and fully stocked. Great price and quality.👌

Reviewed on Nov 7, 2025

Red Roof Inn Toledo - University
Renaissance Toledo Downtown Hotel

Renaissance Toledo Downtown Hotel

4 out of 5
444 N Summit Street Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Toledo. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the restaurant and the helpful ...
8.4/10 Very Good! (1,003 reviews)
The service was very good and the breakfast is decent. Would stay again.

Reviewed on Nov 11, 2025

Renaissance Toledo Downtown Hotel
Motel 6 Toledo, OH

Motel 6 Toledo, OH

2 out of 5
5335 Heatherdowns Blvd Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Stay at this motel in Toledo. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.2/10 (1,008 reviews)
All are good.

Reviewed on Nov 20, 2025

Motel 6 Toledo, OH
Comfort Inn & Suites Toledo North

Comfort Inn & Suites Toledo North

2.5 out of 5
5865 Hagman Rd Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Toledo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
7.8/10 Good! (1,007 reviews)
Room was clean and shower was HOT just how I like it. But the tub drain was clogged. Not a huge deal but I don’t necessarily like taking a shower in standing water. I would stay here again however.

Reviewed on Nov 23, 2025

Comfort Inn & Suites Toledo North
TRU by Hilton Perrysburg Toledo, OH

TRU by Hilton Perrysburg Toledo, OH

2.5 out of 5
9735 Clark Drive Perrysburg OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Perrysburg. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
8.6/10 Excellent! (466 reviews)
It was clean, easy to access, and had a friendly staff. Breakfast was ok, but still a clean set up.

Reviewed on Nov 22, 2025

TRU by Hilton Perrysburg Toledo, OH
Delta Hotels by Marriott Toledo

Delta Hotels by Marriott Toledo

3.5 out of 5
3100 Glendale Avenue Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Toledo. Enjoy free WiFi, free parking, and room service. Popular attractions Swan Creek Preserve Metropark and ...
8.8/10 Excellent! (299 reviews)
As always pleasant staff.

Reviewed on Nov 25, 2025

Delta Hotels by Marriott Toledo
Comfort Suites Perrysburg - Toledo South

Comfort Suites Perrysburg - Toledo South

2.5 out of 5
27450 Helen Dr Perrysburg OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Perrysburg. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.8/10 Good! (1,009 reviews)
Staff was very kind and room was perfect!! Absolutely will stay again

Reviewed on Nov 26, 2025

Comfort Suites Perrysburg - Toledo South
Belamere Suites Hotel

Belamere Suites Hotel

3.5 out of 5
12200 Williams Rd Perrysburg OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Stay at this hotel in Perrysburg. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Perry's Junction and Bicentennial Park are located ...
9.4/10 Exceptional! (148 reviews)
Great stay

Reviewed on Nov 6, 2025

Belamere Suites Hotel
Comfort Inn & Suites Maumee - Toledo (I80-90)

Comfort Inn & Suites Maumee - Toledo (I80-90)

2.5 out of 5
1702 Toll Gate Dr Maumee OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Maumee. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (1,010 reviews)
Everyone was friendly

Reviewed on Nov 25, 2025

Comfort Inn & Suites Maumee - Toledo (I80-90)
Holiday Inn Express & Suites Toledo West by IHG

Holiday Inn Express & Suites Toledo West by IHG

2.5 out of 5
3440 Secor Road Toledo OH
  • 2 hours drive from ProMedica Defiance Regional Hospital
Book a stay at this business-friendly hotel in Toledo. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms ...
8.6/10 Excellent! (1,002 reviews)
There were some misses in cleaning the room. What was best, the room was quiet and comfortable.

Reviewed on Nov 23, 2025

Holiday Inn Express & Suites Toledo West by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Defiance

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If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $53. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get great Defiance hotel deals at the last minute.

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Frequently Asked Questions About Defiance hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Defiance?

With over 725 hotels in Defiance, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $53.

How to find cheap car rentals in Defiance?

Finding a cheap car rental deal in Defiance is as easy as scoring cheap hotels in Defiance. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can unlock great car rental deals if you book a Hotwire Hot Rate at the last minute.