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De Soto

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De Soto Flights as Low as $125

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Frontier Airlines
Thu, Aug 21 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$125 Roundtrip, found 1 hour ago
$125
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Thu, Aug 21 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $125 found 1 hour ago
United
Fri, Aug 1 - Mon, Aug 4
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$163 Roundtrip, found 2 days ago
$163
Roundtrip
found 2 days ago
Select United flight, departing Fri, Aug 1 from O'Hare Intl. to Des Moines Intl., returning Mon, Aug 4, priced at $163 found 2 days ago
American Airlines
Tue, Jul 29 - Sun, Aug 3
ORD
O'Hare Intl.
DSM
Des Moines Intl.
$193 Roundtrip, found 3 hours ago
$193
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Tue, Jul 29 from O'Hare Intl. to Des Moines Intl., returning Sun, Aug 3, priced at $193 found 3 hours ago
Delta
Thu, Aug 21 - Thu, Aug 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$194 Roundtrip, found 1 hour ago
$194
Roundtrip
found 1 hour ago
Select Delta flight, departing Thu, Aug 21 from Denver Intl. to Des Moines Intl., returning Thu, Aug 21, priced at $194 found 1 hour ago
Frontier Airlines
Sat, Sep 27 - Thu, Oct 2
ELP
El Paso Intl.
DSM
Des Moines Intl.
$205 Roundtrip, found 15 hours ago
$205
Roundtrip
found 15 hours ago
Select Frontier Airlines flight, departing Sat, Sep 27 from El Paso Intl. to Des Moines Intl., returning Thu, Oct 2, priced at $205 found 15 hours ago
American Airlines
Wed, Aug 6 - Tue, Aug 12
BWI
Baltimore Washington Intl. Thurgood Marshall
DSM
Des Moines Intl.
$217 Roundtrip, found 2 days ago
$217
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Aug 6 from Baltimore Washington Intl. Thurgood Marshall to Des Moines Intl., returning Tue, Aug 12, priced at $217 found 2 days ago
Delta
Thu, Jul 24 - Tue, Jul 29
MIA
Miami Intl.
DSM
Des Moines Intl.
$217 Roundtrip, found 22 hours ago
$217
Roundtrip
found 22 hours ago
Select Delta flight, departing Thu, Jul 24 from Miami Intl. to Des Moines Intl., returning Tue, Jul 29, priced at $217 found 22 hours ago
Bargain Flight
Tue, Jul 29 - Wed, Aug 6
JAX
Jacksonville Intl.
DSM
Des Moines Intl.
$249 Roundtrip, found 15 hours ago
$249
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Tue, Jul 29 from Jacksonville Intl. to Des Moines Intl., returning Wed, Aug 6, priced at $249 found 15 hours ago
Bargain Flight
Tue, Jul 22 - Tue, Jul 29
BOS
Logan Intl.
DSM
Des Moines Intl.
$258 Roundtrip, found 2 hours ago
$258
Roundtrip
found 2 hours ago
Select Bargain Flight flight, departing Tue, Jul 22 from Logan Intl. to Des Moines Intl., returning Tue, Jul 29, priced at $258 found 2 hours ago
Bargain Flight
Tue, Jul 15 - Tue, Jul 22
MCO
Orlando Intl.
DSM
Des Moines Intl.
$270 Roundtrip, found 2 days ago
$270
Roundtrip
found 2 days ago
Select Bargain Flight flight, departing Tue, Jul 15 from Orlando Intl. to Des Moines Intl., returning Tue, Jul 22, priced at $270 found 2 days ago
Bargain Flight
Wed, Jul 9 - Wed, Jul 16
SAN
San Diego Intl.
DSM
Des Moines Intl.
$276 Roundtrip, found 4 days ago
$276
Roundtrip
found 4 days ago
Select Bargain Flight flight, departing Wed, Jul 9 from San Diego Intl. to Des Moines Intl., returning Wed, Jul 16, priced at $276 found 4 days ago
American Airlines
Wed, Jul 30 - Tue, Aug 5
CLD
McClellan-Palomar
DSM
Des Moines Intl.
$309 Roundtrip, found 8 hours ago
$309
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Jul 30 from McClellan-Palomar to Des Moines Intl., returning Tue, Aug 5, priced at $309 found 8 hours ago
American Airlines
Tue, Jul 29 - Tue, Aug 12
BOI
Boise
DSM
Des Moines Intl.
$317 Roundtrip, found 13 hours ago
$317
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Tue, Jul 29 from Boise to Des Moines Intl., returning Tue, Aug 12, priced at $317 found 13 hours ago
Delta
Tue, Aug 5 - Tue, Aug 12
ROC
Greater Rochester Intl.
DSM
Des Moines Intl.
$323 Roundtrip, found 1 day ago
$323
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Aug 5 from Greater Rochester Intl. to Des Moines Intl., returning Tue, Aug 12, priced at $323 found 1 day ago
United
Thu, Jul 3 - Wed, Jul 9
HLN
Helena Regional
DSM
Des Moines Intl.
$386 Roundtrip, found 23 hours ago
$386
Roundtrip
found 23 hours ago
Select United flight, departing Thu, Jul 3 from Helena Regional to Des Moines Intl., returning Wed, Jul 9, priced at $386 found 23 hours ago
Alaska Airlines
Tue, Jul 29 - Tue, Aug 12
BOI
Boise
DSM
Des Moines Intl.
$452 Roundtrip, found 13 hours ago
$452
Roundtrip
found 13 hours ago
Select Alaska Airlines flight, departing Tue, Jul 29 from Boise to Des Moines Intl., returning Tue, Aug 12, priced at $452 found 13 hours ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 12 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $125, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $125 right now, why wait?

De Soto Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$124

Last Minute Hotel Deals in De Soto

Edgetowner Motel
Edgetowner Motel
2.5 out of 5
804 Guthrie St, De Soto, IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
6/10 (138 reviews)
"Its what i was looking for"

Reviewed on Apr 21, 2025

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Edgetowner Motel
Days Inn & Suites by Wyndham Des Moines Airport
Days Inn & Suites by Wyndham Des Moines Airport
2 out of 5
1901 Hackley Ave, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.4/10 Very Good! (1,509 reviews)
"Room was comfortable. Front desk check-in clerk was very pleasant, as was morning check-out. Free breakfast was very nice, several hot and cold options."

Reviewed on Jun 26, 2025

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Days Inn & Suites by Wyndham Des Moines Airport
Motel 6 West Des Moines, IA
Motel 6 West Des Moines, IA
2 out of 5
7655 Office Plaza Dr N, West Des Moines, IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
8/10 Very Good! (405 reviews)
Friendly and clean
"Service dog and myself stayed two nights in a row to rest and cool off from the heatwave"

Reviewed on Jun 25, 2025

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Motel 6 West Des Moines, IA
Quality Inn & Suites Des Moines - Merle Hay Road
Quality Inn & Suites Des Moines - Merle Hay Road
2.5 out of 5
4995 Merle Hay Rd, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.4/10 Good! (938 reviews)
Great
"We had a few complications but they set everything right. Great people. Will definitely stay again."

Reviewed on Jun 28, 2025

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Quality Inn & Suites Des Moines - Merle Hay Road
Stoney Creek Hotel Des Moines - Johnston
Stoney Creek Hotel Des Moines - Johnston
2.5 out of 5
5291 Stoney Creek Court, Johnston, IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,733 reviews)
"We stayed in the “Cottages” - large rooms and quiet"

Reviewed on Jun 28, 2025

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Stoney Creek Hotel Des Moines - Johnston
Days Inn by Wyndham West Des Moines / Clive
Days Inn by Wyndham West Des Moines / Clive
2 out of 5
1600 NW 114th St, Clive, IA
Book a stay at this business-friendly hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Jordan Creek Town Center and Clive ...
6/10 (1,001 reviews)
"The curtain isnt fully up, there is a vent cover missing from my bathroom & the flip door lock is broken off"

Reviewed on Jun 27, 2025

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Days Inn by Wyndham West Des Moines / Clive
Wildwood Lodge
Wildwood Lodge
3 out of 5
11431 Forest Ave, Clive, IA
Stay at this 3-star hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
9.4/10 Exceptional! (1,205 reviews)
"We stayed for 4 nights while my daughter was participating in a national competition. I booked this hotel without much research, but I’m so glad I did — it turned out to be the perfect choice. The staff were incredibly friendly, and there are plenty of great restaurants nearby. The pool was excellent, ..."

Reviewed on Jun 23, 2025

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Wildwood Lodge
Sonesta Essential Des Moines
Sonesta Essential Des Moines
2 out of 5
4755 Merle Hay Road, Des Moines, IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
7.2/10 Good! (1,000 reviews)
"Great"

Reviewed on Jun 26, 2025

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Sonesta Essential Des Moines
See all 382 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.