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De Soto

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De Soto Flights as Low as $204

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Bargain Flight
Thu, Oct 29 - Wed, Nov 4
GRR
Gerald R. Ford Intl.
DSM
Des Moines Intl.
$204 Roundtrip, found 15 hours ago
$204
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Thu, Oct 29 from Gerald R. Ford Intl. to Des Moines Intl., returning Wed, Nov 4, priced at $204 found 15 hours ago
Frontier Airlines
Mon, Aug 31 - Mon, Sep 14
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$246 Roundtrip, found 2 days ago
$246
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Aug 31 from Los Angeles Intl. to Des Moines Intl., returning Mon, Sep 14, priced at $246 found 2 days ago
Bargain Flight
Tue, Sep 8 - Tue, Sep 22
BWI
Baltimore Washington Intl. Thurgood Marshall
DSM
Des Moines Intl.
$267 Roundtrip, found 5 days ago
$267
Roundtrip
found 5 days ago
Select Bargain Flight flight, departing Tue, Sep 8 from Baltimore Washington Intl. Thurgood Marshall to Des Moines Intl., returning Tue, Sep 22, priced at $267 found 5 days ago
United
Mon, Sep 28 - Wed, Oct 14
IAH
George Bush Intercontinental
DSM
Des Moines Intl.
$269 Roundtrip, found 15 hours ago
$269
Roundtrip
found 15 hours ago
Select United flight, departing Mon, Sep 28 from George Bush Intercontinental to Des Moines Intl., returning Wed, Oct 14, priced at $269 found 15 hours ago
Frontier Airlines
Mon, Sep 21 - Mon, Oct 5
ATL
Hartsfield-Jackson Atlanta Intl.
DSM
Des Moines Intl.
$270 Roundtrip, found 4 days ago
$270
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Mon, Sep 21 from Hartsfield-Jackson Atlanta Intl. to Des Moines Intl., returning Mon, Oct 5, priced at $270 found 4 days ago
Delta
Fri, Oct 30 - Wed, Nov 4
GRR
Gerald R. Ford Intl.
DSM
Des Moines Intl.
$286 Roundtrip, found 15 hours ago
$286
Roundtrip
found 15 hours ago
Select Delta flight, departing Fri, Oct 30 from Gerald R. Ford Intl. to Des Moines Intl., returning Wed, Nov 4, priced at $286 found 15 hours ago
Bargain Flight
Wed, Sep 2 - Sat, Sep 19
LGA
LaGuardia
DSM
Des Moines Intl.
$289 Roundtrip, found 15 hours ago
$289
Roundtrip
found 15 hours ago
Select Bargain Flight flight, departing Wed, Sep 2 from LaGuardia to Des Moines Intl., returning Sat, Sep 19, priced at $289 found 15 hours ago
Frontier Airlines
Wed, Aug 5 - Mon, Aug 10
MCO
Orlando Intl.
DSM
Des Moines Intl.
$300 Roundtrip, found 1 day ago
$300
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Wed, Aug 5 from Orlando Intl. to Des Moines Intl., returning Mon, Aug 10, priced at $300 found 1 day ago
Delta
Sat, Sep 12 - Sun, Sep 13
GSO
Piedmont Triad Intl.
DSM
Des Moines Intl.
$316 Roundtrip, found 1 day ago
$316
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 12 from Piedmont Triad Intl. to Des Moines Intl., returning Sun, Sep 13, priced at $316 found 1 day ago
Bargain Flight
Wed, Jul 22 - Fri, Jul 31
SAN
San Diego Intl.
DSM
Des Moines Intl.
$337 Roundtrip, found 14 hours ago
$337
Roundtrip
found 14 hours ago
Select Bargain Flight flight, departing Wed, Jul 22 from San Diego Intl. to Des Moines Intl., returning Fri, Jul 31, priced at $337 found 14 hours ago
United
Thu, Nov 26 - Mon, Dec 7
SMF
Sacramento Intl.
DSM
Des Moines Intl.
$361 Roundtrip, found 15 hours ago
$361
Roundtrip
found 15 hours ago
Select United flight, departing Thu, Nov 26 from Sacramento Intl. to Des Moines Intl., returning Mon, Dec 7, priced at $361 found 15 hours ago
Delta
Wed, Sep 23 - Wed, Oct 7
SJC
Norman Y. Mineta San Jose Intl.
DSM
Des Moines Intl.
$368 Roundtrip, found 3 days ago
$368
Roundtrip
found 3 days ago
Select Delta flight, departing Wed, Sep 23 from Norman Y. Mineta San Jose Intl. to Des Moines Intl., returning Wed, Oct 7, priced at $368 found 3 days ago
Delta
Thu, Nov 26 - Tue, Dec 1
EUG
Eugene
DSM
Des Moines Intl.
$401 Roundtrip, found 1 day ago
$401
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Nov 26 from Eugene to Des Moines Intl., returning Tue, Dec 1, priced at $401 found 1 day ago
Frontier Airlines
Mon, Jul 27 - Fri, Jul 31
SFO
San Francisco Intl.
DSM
Des Moines Intl.
$472 Roundtrip, found 1 day ago
$472
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Mon, Jul 27 from San Francisco Intl. to Des Moines Intl., returning Fri, Jul 31, priced at $472 found 1 day ago
American Airlines
Wed, Jul 29 - Mon, Aug 10
CLD
McClellan-Palomar
DSM
Des Moines Intl.
$499 Roundtrip, found 15 hours ago
$499
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Wed, Jul 29 from McClellan-Palomar to Des Moines Intl., returning Mon, Aug 10, priced at $499 found 15 hours ago
American Airlines
Sat, Dec 19 - Tue, Dec 29
ONT
Ontario Intl. Airport
DSM
Des Moines Intl.
$742 Roundtrip, found 1 day ago
$742
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, Dec 19 from Ontario Intl. Airport to Des Moines Intl., returning Tue, Dec 29, priced at $742 found 1 day ago

Cheap Flights to De Soto

Fall in love at first flight with your vacation to De Soto by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to De Soto on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in De Soto, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to De Soto

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to De Soto with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the DSM airport.

What is the cheapest month to fly to De Soto?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to De Soto are in October, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to De Soto?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 12 to choose from for your flight to De Soto.

What airport is best to fly into De Soto?

When you’re planning your trip to De Soto, convenience is the name of the game. Luckily, De Soto Des Moines Intl. Airport is nearby so you can deplane and get going on checking off everything on your De Soto must-do list.

How much are flights to De Soto?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to De Soto on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $204, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to De Soto?

The trick to saving a stack of cash on your flight to De Soto? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $204 right now, why wait?

De Soto Flight Information
Destination airport
Des Moines Intl.
Destination airport IATA code
DSM
Roundtrip price
$203

Last Minute Hotel Deals in De Soto

Edgetowner Motel

Edgetowner Motel

2.5 out of 5
804 Guthrie St De Soto IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
6.2/10 (166 reviews)
"Our room had bed bugs!!! There was dirt and hair in the bathroom and stains on the sheets, the smoke detector was on the dresser with the battery out but when we put it in it didnt work anyways. The only positive was the lady that ran the building was very nice.... will NEVER EVER stay here again.. ..."

Reviewed on Jun 28, 2026

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Edgetowner Motel
Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
8.6/10 Excellent! (1,829 reviews)
"I had reserved my rooms a month in a month to have rooms connected or by each other when we got there we were on one floor are sons were on another"

Reviewed on Jul 19, 2026

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Days Inn & Suites by Wyndham Des Moines Airport
Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

3 out of 5
5000 Merle Hay Rd Urbandale IA
Book a stay at this family-friendly hotel in Urbandale. Enjoy free WiFi, free parking, and a water park. Our guests praise the helpful staff and the clean rooms ...
5.8/10 (944 reviews)
"The pool area for the kids was clean and attendants were very friendly. Carpeting was in poor condition. The rooms were spacious but were outdated and need serious work. Our door didn't want to stay shut, the window of the bedroom looked as if it had been broken into and wouldn't close. Had maintenance ..."

Reviewed on Jul 20, 2026

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Ramada Tropics Resort & Conf Center by Wyndham Des Moines
Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton

Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton

4.5 out of 5
11211 Hickman Rd Urbandale IA
Book a stay at this luxury hotel in Urbandale. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
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Revel Hotel Des Moines Urbandale, Tapestry Collection by Hilton
Stoney Creek Hotel Des Moines - Johnston

Stoney Creek Hotel Des Moines - Johnston

2.5 out of 5
5291 Stoney Creek Court Johnston IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
8.8/10 Excellent! (1,870 reviews)
"It is under construction and wasn't told that. Had to call the hotel to get someone to the registration desk to check in as no one was there. I'm sure it will be good once construction is done."

Reviewed on Jul 20, 2026

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Stoney Creek Hotel Des Moines - Johnston
GrandStay Hotel & Suites

GrandStay Hotel & Suites

2 out of 5
6215 Merle Hay Road Johnston IA
Stay at this hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Iowa Gold Star Military Museum and Merle Hay Mall are ...
9.4/10 Exceptional! (689 reviews)
"We have stayed here several times & always enjoy the property. Shout out this time to the person running the breakfast. Everything was out on time, kept refills and variety of options stocked."

Reviewed on Jul 20, 2026

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GrandStay Hotel & Suites
Drury Inn & Suites West Des Moines

Drury Inn & Suites West Des Moines

3 out of 5
5505 Mills Civic Pkwy West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
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Drury Inn & Suites West Des Moines
Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA

2 out of 5
7655 Office Plaza Dr N West Des Moines IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
7.8/10 Good! (958 reviews)
"I’ve stayed here several times and this time my experience wasn’t so good."

Reviewed on Jul 19, 2026

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Motel 6 West Des Moines, IA
See all 419 properties in De Soto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.