Search Cheap Flights to
Santa Cruz do Douro

Photo by Jazzinto

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Santa Cruz do Douro Flights as Low as $115

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

TAP Portugal
Sat, Nov 15 - Sat, Nov 22
SVQ
San Pablo
OPO
Dr. Francisco de Sa Carneiro
$115 Roundtrip, found 11 hours ago
$115
Roundtrip
found 11 hours ago
Select TAP Portugal flight, departing Sat, Nov 15 from San Pablo to Dr. Francisco de Sa Carneiro, returning Sat, Nov 22, priced at $115 found 11 hours ago
TAP Portugal
Sat, Jul 5 - Sat, Jul 19
MAD
Adolfo Suárez Madrid-Barajas
OPO
Dr. Francisco de Sa Carneiro
$125 Roundtrip, found 4 hours ago
$125
Roundtrip
found 4 hours ago
Select TAP Portugal flight, departing Sat, Jul 5 from Adolfo Suárez Madrid-Barajas to Dr. Francisco de Sa Carneiro, returning Sat, Jul 19, priced at $125 found 4 hours ago
Iberia
Sun, Jul 6 - Wed, Jul 16
MAD
Adolfo Suárez Madrid-Barajas
OPO
Dr. Francisco de Sa Carneiro
$125 Roundtrip, found 16 hours ago
$125
Roundtrip
found 16 hours ago
Select Iberia flight, departing Sun, Jul 6 from Adolfo Suárez Madrid-Barajas to Dr. Francisco de Sa Carneiro, returning Wed, Jul 16, priced at $125 found 16 hours ago
Air Europa
Sun, Jul 6 - Wed, Jul 16
MAD
Adolfo Suárez Madrid-Barajas
OPO
Dr. Francisco de Sa Carneiro
$135 Roundtrip, found 16 hours ago
$135
Roundtrip
found 16 hours ago
Select Air Europa flight, departing Sun, Jul 6 from Adolfo Suárez Madrid-Barajas to Dr. Francisco de Sa Carneiro, returning Wed, Jul 16, priced at $135 found 16 hours ago
Vueling Airlines
Sat, Nov 15 - Sat, Nov 22
SVQ
San Pablo
OPO
Dr. Francisco de Sa Carneiro
$139 Roundtrip, found 11 hours ago
$139
Roundtrip
found 11 hours ago
Select Vueling Airlines flight, departing Sat, Nov 15 from San Pablo to Dr. Francisco de Sa Carneiro, returning Sat, Nov 22, priced at $139 found 11 hours ago
Iberia
Fri, Nov 14 - Sun, Nov 23
SVQ
San Pablo
OPO
Dr. Francisco de Sa Carneiro
$151 Roundtrip, found 2 days ago
$151
Roundtrip
found 2 days ago
Select Iberia flight, departing Fri, Nov 14 from San Pablo to Dr. Francisco de Sa Carneiro, returning Sun, Nov 23, priced at $151 found 2 days ago
Iberia
Tue, Jul 8 - Tue, Jul 15
FRA
Frankfurt Intl.
OPO
Dr. Francisco de Sa Carneiro
$295 Roundtrip, found 22 hours ago
$295
Roundtrip
found 22 hours ago
Select Iberia flight, departing Tue, Jul 8 from Frankfurt Intl. to Dr. Francisco de Sa Carneiro, returning Tue, Jul 15, priced at $295 found 22 hours ago
Swiss International Air Lines
Sat, Nov 15 - Sat, Nov 22
SVQ
San Pablo
OPO
Dr. Francisco de Sa Carneiro
$332 Roundtrip, found 11 hours ago
$332
Roundtrip
found 11 hours ago
Select Swiss International Air Lines flight, departing Sat, Nov 15 from San Pablo to Dr. Francisco de Sa Carneiro, returning Sat, Nov 22, priced at $332 found 11 hours ago
KLM
Tue, Jul 8 - Fri, Jul 18
FRA
Frankfurt Intl.
OPO
Dr. Francisco de Sa Carneiro
$341 Roundtrip, found 1 day ago
$341
Roundtrip
found 1 day ago
Select KLM flight, departing Tue, Jul 8 from Frankfurt Intl. to Dr. Francisco de Sa Carneiro, returning Fri, Jul 18, priced at $341 found 1 day ago
Iberia
Mon, Oct 20 - Fri, Nov 7
BOS
Logan Intl.
OPO
Dr. Francisco de Sa Carneiro
$373 Roundtrip, found 23 hours ago
$373
Roundtrip
found 23 hours ago
Select Iberia flight, departing Mon, Oct 20 from Logan Intl. to Dr. Francisco de Sa Carneiro, returning Fri, Nov 7, priced at $373 found 23 hours ago
Lufthansa
Fri, Sep 5 - Tue, Sep 23
TLV
Ben Gurion
OPO
Dr. Francisco de Sa Carneiro
$398 Roundtrip, found 6 hours ago
$398
Roundtrip
found 6 hours ago
Select Lufthansa flight, departing Fri, Sep 5 from Ben Gurion to Dr. Francisco de Sa Carneiro, returning Tue, Sep 23, priced at $398 found 6 hours ago
TAP Portugal
Tue, Nov 18 - Sat, Nov 22
EWR
Newark Liberty Intl. Airport
OPO
Dr. Francisco de Sa Carneiro
$450 Roundtrip, found 22 hours ago
$450
Roundtrip
found 22 hours ago
Select TAP Portugal flight, departing Tue, Nov 18 from Newark Liberty Intl. Airport to Dr. Francisco de Sa Carneiro, returning Sat, Nov 22, priced at $450 found 22 hours ago
Air Transat
Mon, Jul 14 - Wed, Jul 16
YYZ
Pearson Intl.
OPO
Dr. Francisco de Sa Carneiro
$713 Roundtrip, found 21 hours ago
$713
Roundtrip
found 21 hours ago
Select Air Transat flight, departing Mon, Jul 14 from Pearson Intl. to Dr. Francisco de Sa Carneiro, returning Wed, Jul 16, priced at $713 found 21 hours ago
United
Wed, Sep 24 - Fri, Oct 3
DTW
Detroit Metropolitan Wayne County
OPO
Dr. Francisco de Sa Carneiro
$735 Roundtrip, found 13 hours ago
$735
Roundtrip
found 13 hours ago
Select United flight, departing Wed, Sep 24 from Detroit Metropolitan Wayne County to Dr. Francisco de Sa Carneiro, returning Fri, Oct 3, priced at $735 found 13 hours ago
KLM
Tue, Sep 30 - Fri, Oct 10
BWI
Baltimore Washington Intl. Thurgood Marshall
OPO
Dr. Francisco de Sa Carneiro
$769 Roundtrip, found 23 hours ago
$769
Roundtrip
found 23 hours ago
Select KLM flight, departing Tue, Sep 30 from Baltimore Washington Intl. Thurgood Marshall to Dr. Francisco de Sa Carneiro, returning Fri, Oct 10, priced at $769 found 23 hours ago
LATAM Airlines Group
Mon, Jul 28 - Mon, Aug 25
AEP
Aeroparque Jorge Newbery
OPO
Dr. Francisco de Sa Carneiro
$1,494 Roundtrip, found 22 hours ago
$1,494
Roundtrip
found 22 hours ago
Select LATAM Airlines Group flight, departing Mon, Jul 28 from Aeroparque Jorge Newbery to Dr. Francisco de Sa Carneiro, returning Mon, Aug 25, priced at $1,494 found 22 hours ago

Cheap Flights to Santa Cruz do Douro

Fall in love at first flight with your vacation to Santa Cruz do Douro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Cruz do Douro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Cruz do Douro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Cruz do Douro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Cruz do Douro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the OPO airport.

What is the cheapest month to fly to Santa Cruz do Douro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Cruz do Douro are in November, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Cruz do Douro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Cruz do Douro.

What airport is best to fly into Santa Cruz do Douro?

When you’re planning your trip to Santa Cruz do Douro, convenience is the name of the game. Luckily, Santa Cruz do Douro Vila Real Airport is nearby so you can deplane and get going on checking off everything on your Santa Cruz do Douro must-do list.

How much are flights to Santa Cruz do Douro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Cruz do Douro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $115, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Cruz do Douro?

The trick to saving a stack of cash on your flight to Santa Cruz do Douro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $115 right now, why wait?

Santa Cruz do Douro Flight Information
Destination airport
Dr. Francisco de Sa Carneiro
Destination airport IATA code
OPO
Roundtrip price
$114

Last Minute Hotel Deals in Santa Cruz do Douro

Douro Palace Hotel Resort and Spa
Douro Palace Hotel Resort and Spa
4 out of 5
Lugar Do Carrapatelo, Santa Cruz do Douro, Baiao
Stay at this 4-star spa hotel in Baiao. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Caldas de Aregos Marina and Caldas de Aregos are ...
8.8/10 Excellent! (236 reviews)
"Absolutely stunning property with a very thought out layout and design. The rooms were very comfortable and quiet and had blackout curtains. The restaurant onsite was also delicious and offered a wide range of options. The SPA was so nice and had the best couples message ever."

Reviewed on Jun 13, 2025

Get rates
Douro Palace Hotel Resort and Spa
Douro Royal Valley Hotel & SPA
Douro Royal Valley Hotel & SPA
5 out of 5
Portela do Rio, Pala - Ribadouro, Baiao
Stay at this 5-star luxury hotel in Baiao. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (299 reviews)
"Amazing location. Great views from the room and the infinity pool! Great food as well!"

Reviewed on Jun 12, 2025

Get rates
Douro Royal Valley Hotel & SPA
Octant Douro
Octant Douro
5 out of 5
Estrada Nacional 222 Km 41, Aveiro District, Castelo de Paiva
Stay at this 5-star luxury hotel in Castelo de Paiva. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the property ...
9.2/10 Wonderful! (305 reviews)
Quiet, comfortable river front hotel
"Beautiful hotel in gorgeous location overlooking the river. It was very quiet and peaceful. The service at the restaurant and bar could be improved. The front desk is very friendly and helpful. I would go again, but would eat dinner outside the hotel. Breakfast was amazing!"

Reviewed on Jun 16, 2025

Get rates
Octant Douro
Six Senses Douro Valley
Six Senses Douro Valley
5 out of 5
Quinta de Vale Abraão, Samodães, Lamego
Stay at this 5-star luxury hotel in Lamego. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Adega - Cadão Douro and Douro Museum are located ...
9.6/10 Exceptional! (220 reviews)
"Outstanding service and facilities to celebrate 40th anniversary. Luisa was wonderful!"

Reviewed on May 5, 2025

Get rates
Six Senses Douro Valley
Lamego Hotel & Life
Lamego Hotel & Life
4 out of 5
Rua de São João, Lamego
Stay at this 4-star spa hotel in Lamego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (272 reviews)
"This was a fabulous stay. The staff was excellent. We really enjoyed our stay. The hotel is in a beautiful location."

Reviewed on Jun 2, 2025

Get rates
Lamego Hotel & Life
Vila Galé Douro Vineyards
Vila Galé Douro Vineyards
4 out of 5
Quinta do Val Moreira - Marmelal, Santo Adrião, Armamar
Stay at this 4-star farm stay in Armamar. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Quinta do Tedo and Quinta do Popa are located ...
8.6/10 Excellent! (133 reviews)
"The property was one of our favorites throughout our trip. The food was goi. Staff was excellent and the views were spectacular."

Reviewed on Jun 1, 2025

Get rates
Vila Galé Douro Vineyards
Casa de São Domingos
Casa de São Domingos
4 out of 5
Avenida Diocese de Vila Real, Nº821, Peso da Régua, Douro Valley
Stay at this 4-star business-friendly B&B in Peso da Régua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9.6/10 Exceptional! (425 reviews)
"Very beautiful property in a tranquil setting. It was within walking distance to several restaurants. The pool and grounds were fantastic! They provide a nice breakfast each morning."

Reviewed on Jun 4, 2025

Get rates
Casa de São Domingos
Torel Quinta da Vacaria - Douro Valley
Torel Quinta da Vacaria - Douro Valley
5 out of 5
Quinta da Vacaria 1616, Peso da Régua, Vila Real District
Stay at this 5-star luxury hotel in Peso da Régua. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Quinta Branca and Quinta dos ...
9.8/10 Exceptional! (51 reviews)
"Fantastic property"

Reviewed on Jun 1, 2025

Get rates
Torel Quinta da Vacaria - Douro Valley
See all 936 properties in Santa Cruz do Douro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.