Search Cheap Flights to
Santa Cruz do Douro

Search 400 airlines and 321,000 hotels worldwide.

Stop Planning & Start Exploring

FREE 24 hour cancellation on most flights

Santa Cruz do Douro Flights as Low as $114

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Wizz Air Malta
Mon, Jul 13 - Tue, Jul 28
FCO
Fiumicino - Leonardo da Vinci Intl.
OPO
Dr. Francisco de Sa Carneiro
$114 Roundtrip, found 1 day ago
$114
Roundtrip
found 1 day ago
Select Wizz Air Malta flight, departing Mon, Jul 13 from Fiumicino - Leonardo da Vinci Intl. to Dr. Francisco de Sa Carneiro, returning Tue, Jul 28, priced at $114 found 1 day ago
Iberia
Tue, Jul 14 - Tue, Jul 28
FCO
Fiumicino - Leonardo da Vinci Intl.
OPO
Dr. Francisco de Sa Carneiro
$187 Roundtrip, found 3 hours ago
$187
Roundtrip
found 3 hours ago
Select Iberia flight, departing Tue, Jul 14 from Fiumicino - Leonardo da Vinci Intl. to Dr. Francisco de Sa Carneiro, returning Tue, Jul 28, priced at $187 found 3 hours ago
Vueling Airlines
Mon, Jul 13 - Tue, Jul 28
FCO
Fiumicino - Leonardo da Vinci Intl.
OPO
Dr. Francisco de Sa Carneiro
$189 Roundtrip, found 1 day ago
$189
Roundtrip
found 1 day ago
Select Vueling Airlines flight, departing Mon, Jul 13 from Fiumicino - Leonardo da Vinci Intl. to Dr. Francisco de Sa Carneiro, returning Tue, Jul 28, priced at $189 found 1 day ago
Vueling Airlines
Wed, Jun 17 - Wed, Jul 1
ZRH
Zürich
OPO
Dr. Francisco de Sa Carneiro
$224 Roundtrip, found 1 day ago
$224
Roundtrip
found 1 day ago
Select Vueling Airlines flight, departing Wed, Jun 17 from Zürich to Dr. Francisco de Sa Carneiro, returning Wed, Jul 1, priced at $224 found 1 day ago
Air Europa
Tue, Jul 14 - Tue, Jul 28
FCO
Fiumicino - Leonardo da Vinci Intl.
OPO
Dr. Francisco de Sa Carneiro
$242 Roundtrip, found 3 hours ago
$242
Roundtrip
found 3 hours ago
Select Air Europa flight, departing Tue, Jul 14 from Fiumicino - Leonardo da Vinci Intl. to Dr. Francisco de Sa Carneiro, returning Tue, Jul 28, priced at $242 found 3 hours ago
Air France
Wed, Jun 17 - Wed, Jul 1
ZRH
Zürich
OPO
Dr. Francisco de Sa Carneiro
$266 Roundtrip, found 1 day ago
$266
Roundtrip
found 1 day ago
Select Air France flight, departing Wed, Jun 17 from Zürich to Dr. Francisco de Sa Carneiro, returning Wed, Jul 1, priced at $266 found 1 day ago
KLM
Wed, Jun 17 - Wed, Jul 1
ZRH
Zürich
OPO
Dr. Francisco de Sa Carneiro
$266 Roundtrip, found 1 day ago
$266
Roundtrip
found 1 day ago
Select KLM flight, departing Wed, Jun 17 from Zürich to Dr. Francisco de Sa Carneiro, returning Wed, Jul 1, priced at $266 found 1 day ago
TAP Portugal
Tue, Sep 1 - Wed, Sep 16
DUS
Düsseldorf Intl.
OPO
Dr. Francisco de Sa Carneiro
$267 Roundtrip, found 20 hours ago
$267
Roundtrip
found 20 hours ago
Select TAP Portugal flight, departing Tue, Sep 1 from Düsseldorf Intl. to Dr. Francisco de Sa Carneiro, returning Wed, Sep 16, priced at $267 found 20 hours ago
TAP Portugal
Tue, Sep 1 - Wed, Sep 16
DUS
Düsseldorf Intl.
OPO
Dr. Francisco de Sa Carneiro
$280 Roundtrip, found 20 hours ago
$280
Roundtrip
found 20 hours ago
Select TAP Portugal flight, departing Tue, Sep 1 from Düsseldorf Intl. to Dr. Francisco de Sa Carneiro, returning Wed, Sep 16, priced at $280 found 20 hours ago
Scandinavian Airlines
Wed, Jun 17 - Wed, Jul 1
ZRH
Zürich
OPO
Dr. Francisco de Sa Carneiro
$286 Roundtrip, found 1 day ago
$286
Roundtrip
found 1 day ago
Select Scandinavian Airlines flight, departing Wed, Jun 17 from Zürich to Dr. Francisco de Sa Carneiro, returning Wed, Jul 1, priced at $286 found 1 day ago
Eurowings
Fri, Aug 14 - Fri, Sep 4
DUS
Düsseldorf Intl.
OPO
Dr. Francisco de Sa Carneiro
$319 Roundtrip, found 1 day ago
$319
Roundtrip
found 1 day ago
Select Eurowings flight, departing Fri, Aug 14 from Düsseldorf Intl. to Dr. Francisco de Sa Carneiro, returning Fri, Sep 4, priced at $319 found 1 day ago
FlexFlight
Tue, Sep 1 - Wed, Sep 16
QDU
Düsseldorf Central Train Station
OPO
Dr. Francisco de Sa Carneiro
$486 Roundtrip, found 6 days ago
$486
Roundtrip
found 6 days ago
Select FlexFlight flight, departing Tue, Sep 1 from Düsseldorf Central Train Station to Dr. Francisco de Sa Carneiro, returning Wed, Sep 16, priced at $486 found 6 days ago
Scandinavian Airlines
Wed, Nov 25 - Fri, Dec 4
JFK
John F. Kennedy Intl.
OPO
Dr. Francisco de Sa Carneiro
$616 Roundtrip, found 6 days ago
$616
Roundtrip
found 6 days ago
Select Scandinavian Airlines flight, departing Wed, Nov 25 from John F. Kennedy Intl. to Dr. Francisco de Sa Carneiro, returning Fri, Dec 4, priced at $616 found 6 days ago
Scandinavian Airlines
Thu, Aug 27 - Thu, Sep 17
EWR
Newark Liberty Intl. Airport
OPO
Dr. Francisco de Sa Carneiro
$646 Roundtrip, found 5 hours ago
$646
Roundtrip
found 5 hours ago
Select Scandinavian Airlines flight, departing Thu, Aug 27 from Newark Liberty Intl. Airport to Dr. Francisco de Sa Carneiro, returning Thu, Sep 17, priced at $646 found 5 hours ago
TAP Portugal
Mon, Aug 10 - Wed, Aug 26
IAD
Washington Dulles Intl.
OPO
Dr. Francisco de Sa Carneiro
$745 Roundtrip, found 18 hours ago
$745
Roundtrip
found 18 hours ago
Select TAP Portugal flight, departing Mon, Aug 10 from Washington Dulles Intl. to Dr. Francisco de Sa Carneiro, returning Wed, Aug 26, priced at $745 found 18 hours ago
American Airlines
Tue, Sep 22 - Wed, Sep 30
ATL
Hartsfield-Jackson Atlanta Intl.
OPO
Dr. Francisco de Sa Carneiro
$842 Roundtrip, found 1 day ago
$842
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Sep 22 from Hartsfield-Jackson Atlanta Intl. to Dr. Francisco de Sa Carneiro, returning Wed, Sep 30, priced at $842 found 1 day ago

Cheap Flights to Santa Cruz do Douro

Fall in love at first flight with your vacation to Santa Cruz do Douro by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Cruz do Douro on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Cruz do Douro, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Cruz do Douro

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Cruz do Douro with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the OPO airport.

What is the cheapest month to fly to Santa Cruz do Douro?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Cruz do Douro are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Cruz do Douro?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Cruz do Douro.

What airport is best to fly into Santa Cruz do Douro?

When you’re planning your trip to Santa Cruz do Douro, convenience is the name of the game. Luckily, Santa Cruz do Douro Vila Real Airport is nearby so you can deplane and get going on checking off everything on your Santa Cruz do Douro must-do list.

How much are flights to Santa Cruz do Douro?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Cruz do Douro on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $114, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Cruz do Douro?

The trick to saving a stack of cash on your flight to Santa Cruz do Douro? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $114 right now, why wait?

Santa Cruz do Douro Flight Information
Destination airport
Dr. Francisco de Sa Carneiro
Destination airport IATA code
OPO
Roundtrip price
$113

Last Minute Hotel Deals in Santa Cruz do Douro

Douro Palace Hotel Resort and Spa

Douro Palace Hotel Resort and Spa

4 out of 5
Lugar Do Carrapatelo Baiao
Book a stay at this spa hotel in Baiao. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Caldas de Aregos Marina and Caldas de Aregos are ...
8.8/10 Excellent! (269 reviews)
"Very clean rooms. Great hotel to stay at and great bar."

Reviewed on May 16, 2026

Get rates
Douro Palace Hotel Resort and Spa
Six Senses Douro Valley

Six Senses Douro Valley

5 out of 5
Quinta de Vale Abraão Lamego
Book a stay at this luxury hotel in Lamego. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Adega - Cadão Douro and Douro Museum are ...
9.8/10 Exceptional! (247 reviews)
"Absolutely breathtaking. The views, the location, the service, the food. I could write a novel and not capture everything. If you have an opportunity to book the Six Senses, do it!! You’ll be tempted to skip breakfast because you’re cocooned in the delicious bedding. Resist that temptation. The breakfast ..."

Reviewed on May 21, 2026

Get rates
Six Senses Douro Valley
Octant Douro

Octant Douro

5 out of 5
Estrada Nacional 222 Km 41 Castelo de Paiva
Book a stay at this luxury hotel in Castelo de Paiva. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
9.4/10 Exceptional! (359 reviews)
"I read a number of the negative reviews (after I had booked) and arrived at the hotel with anticipation of being disappointed. I am glad to say we had a lovely stay. Food was good, staff helpful, it is a lovely setting. I stayed in the river view suite and the room was great. Design good and lots ..."

Reviewed on May 21, 2026

Get rates
Octant Douro
Douro Royal Valley Hotel & SPA

Douro Royal Valley Hotel & SPA

5 out of 5
Portela do Rio, Pala - Ribadouro Baiao
Book a stay at this luxury hotel in Baiao. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (362 reviews)
"This is by no measure a 5-star property, but a well used 4-star facility. The upkeep is not really up to par, with mold in the bathroom, bathroom doors peeling severly due to water damage, stained towels etc. The breakfast is fine, but, again, not up to 4-star standards (including 5-star hotels in ..."

Reviewed on May 25, 2026

Get rates
Douro Royal Valley Hotel & SPA
Vila Gale Douro Vineyards Hotel

Vila Gale Douro Vineyards Hotel

4 out of 5
Quinta do Val Moreira - Marmelal Armamar
Stay at this farm stay in Armamar. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Quinta do Tedo and Quinta do Popa are located ...
8.8/10 Excellent! (201 reviews)
"Great location and staff was very helpful."

Reviewed on May 25, 2026

Get rates
Vila Gale Douro Vineyards Hotel
The Wine House Hotel - Quinta da Pacheca

The Wine House Hotel - Quinta da Pacheca

4 out of 5
Rua do Relógio do Sol, 261, Cambres Lamego
Book a stay at this spa hotel in Lamego. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.6/10 Exceptional! (467 reviews)
"We chose the wine barrel room and it was a great experience"

Reviewed on Jan 29, 2026

Get rates
The Wine House Hotel - Quinta da Pacheca
Torel Quinta da Vacaria - Douro Valley

Torel Quinta da Vacaria - Douro Valley

5 out of 5
Quinta da Vacaria 1616 Peso da Régua Vila Real District
Book a stay at this luxury hotel in Peso da Régua. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Quinta Branca and Quinta do Vallado ...
9.8/10 Exceptional! (88 reviews)
"Beautiful hotel with fantastic staff. Food was great in both the main restaurant and Schisto (tasting menu). Wine tasting at their vineyard was informative snd fun."

Reviewed on May 21, 2026

Get rates
Torel Quinta da Vacaria - Douro Valley
Vila Gale Collection Douro Hotel

Vila Gale Collection Douro Hotel

4 out of 5
Lugar dos Varais - Cambres Lamego
Book a stay at this spa hotel in Lamego. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9/10 Wonderful! (324 reviews)
"Excellent hotel"

Reviewed on May 15, 2026

Get rates
Vila Gale Collection Douro Hotel
See all 948 properties in Santa Cruz do Douro
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.