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St. Charles Vacation Packages

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St. Charles Flight + Hotel Packages

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Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
Price was $688, price is now $654 per person
$654
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this golf hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant in our reviews. Popular attractions Soldiers Field Veterans Memorial and Soldiers Field Golf Course are located nearby.
there staff supper nice, i will come back

Reviewed on Oct 1, 2026

The Berkman

The Berkman

3 out of 5
Price was $744, price is now $679 per person
$679
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions Kutzky Park Tennis Center and Cascade Lake Beach are located nearby.

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

3 out of 5
Price was $698, price is now $655 per person
$655
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff in our reviews. Popular attractions Kutzky Park Tennis Center and Cascade Lake Beach are located nearby.

Cobblestone Hotel & Suites - Austin

Cobblestone Hotel & Suites - Austin

2.5 out of 5
Price was $688, price is now $658 per person
$658
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Austin. Enjoy free breakfast, free WiFi, and free parking. Popular attractions North West Park and Hormel Foods First Century Museum are located nearby.

Aspen Suites

Aspen Suites

3 out of 5
Price was $716, price is now $685 per person
$685
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Kutzky Park Tennis Center and Cascade Lake Beach are located nearby.

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
Price was $683, price is now $654 per person
$654
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in our reviews. Popular attractions Rochester Public Library and Shops University Square are located nearby.

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
Price was $731, price is now $700 per person
$700
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Plummer Building and Shops University Square are located nearby.
Perfect for the outpatient setting for Mayo. Definitely recommend using valet for just a little more it’s worth it and so easy!

Reviewed on Oct 1, 2026

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

3 out of 5
Price was $721, price is now $690 per person
$690
per person
Dec 6 - Dec 8
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Kutzky Park Tennis Center and Cascade Lake Beach are located nearby.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Delta
Thu, Nov 12 - Mon, Nov 16
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$308 Roundtrip, found 2 days ago
$308
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Nov 12 from Detroit Metropolitan Wayne County to Rochester Intl., returning Mon, Nov 16, priced at $308 found 2 days ago
American Airlines
Tue, Nov 10 - Tue, Nov 17
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$313 Roundtrip, found 1 day ago
$313
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 10 from Detroit Metropolitan Wayne County to Rochester Intl., returning Tue, Nov 17, priced at $313 found 1 day ago
Delta
Wed, Oct 7 - Thu, Oct 15
MSP
Minneapolis - St. Paul Intl.
RST
Rochester Intl.
$333 Roundtrip, found 1 day ago
$333
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Oct 7 from Minneapolis - St. Paul Intl. to Rochester Intl., returning Thu, Oct 15, priced at $333 found 1 day ago
Delta
Thu, Nov 12 - Thu, Nov 19
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$338 Roundtrip, found 2 days ago
$338
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Nov 12 from Detroit Metropolitan Wayne County to Rochester Intl., returning Thu, Nov 19, priced at $338 found 2 days ago