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Medical Center District Vacation Packages

3-4 Night Vacations in Medical Center District

Hotel Gibbs Downtown Riverwalk
Hilton Palacio Del Rio
Embassy Suites by Hilton San Antonio Airport
Crockett Hotel

Cheap Hotel Deals in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

2.5 out of 5
4431 Horizon Hill Blvd, San Antonio, TX, 78229
Stay at this business-friendly aparthotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX, 78229
Stay at this 3-star business-friendly aparthotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Our guests praise the helpful staff and the clean ...
Courtyard by Marriott Medical Center San Antonio
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX, 78205
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the bar and the helpful staff in our ...
Riverwalk Plaza

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Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel

Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel

3 out of 5
318 W Cesar E. Chavez Blvd, San Antonio, TX, 78204
Stay at this 3-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast. Our guests praise the restaurant and the helpful staff ...
Holiday Inn San Antonio - Dwtn - Market Sq, an IHG Hotel
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street, San Antonio, TX, 78205
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, a rooftop terrace, and breakfast. Our guests praise the helpful staff and the clean rooms ...
Hotel Contessa
La Quinta Inn & Suites by Wyndham San Antonio Airport

La Quinta Inn & Suites by Wyndham San Antonio Airport

2.5 out of 5
850 Halm Blvd, San Antonio, TX, 78216
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn & Suites by Wyndham San Antonio Airport
Hampton Inn San Antonio-Downtown (River Walk)

Hampton Inn San Antonio-Downtown (River Walk)

2.5 out of 5
414 Bowie St, San Antonio, TX, 78205
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful staff ...
Hampton Inn San Antonio-Downtown (River Walk)
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza, San Antonio, TX, 78205
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast, and room service. Our guests praise the helpful staff and the clean rooms in ...
Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

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Find cheap hotels in Medical Center District

You’re not an average traveler—and Hotwire knows it. Your wanderlust takes you off the beaten path to discover unique adventures and every travel destination’s lesser-known tourist scenes. Hotwire has the hookup! Book your Medical Center District hotel with Hotwire to complete your one-of-a-kind travel checklist.

For you, intrepid voyager, Hotwire has a large selection of the best hotels in Medical Center District.

Choosing the right hotel in Texas has everything to do with the way you want your trip to go. If you’ve scribbled a few obscure destinations on your itinerary, you probably already have a good sense of how your getaway is taking shape. Lean into that by booking one of Medical Center District’s 100 hotels. Choose the one that best catches your trip’s tourist drift.

If you’re traveling during the week for business, Hotwire can score you a luxury hotel for as low as $79. In town for pleasure? Hotwire still has you covered. If you’re in the mood for a quick last-minute weekend getaway or spa retreat, you can get up to 60% Medical Center District hotel deals at the last minute.

While traveling, where you stay plays a major role in your overall vacation enjoyment. Choosing the right hotel is just as important as making sure you book the right flight and car rental. If you’re traveling with family or friends, you may need to book a hotel with connecting rooms. If you enjoy an elegant and relaxing hotel ambiance, opt for one of Hotwire’s luxury hotels in Medical Center District. No matter your reason for visiting Medical Center District, with Hotwire’s large selection of hotels in the area, you’re sure to book a hotel that meets all your accommodation needs.

Frequently Asked Questions About Medical Center District hotels

Where can I find the best last-minute travel deals?

If you’re traveling in the spirit of spontaneity, you’ll love the idea of leaving your exact hotel choice up to chance. With Hotwire Hot Rates, you can save up to 60% off your next flight, hotel, or car rental. Just plug in your general preferences and let Hotwire choose last-minute hotel deals in Medical Center District for as low as $79.

How many hotels are there in Medical Center District?

With over 100 hotels in Medical Center District, you’re sure to find one that best matches your travel mood. When you book with Hotwire, you can score a stellar home away from home for as low as $79.

How to find cheap car rentals in Medical Center District?

Finding a cheap car rental deal in San Antonio is as easy as scoring cheap hotels in Medical Center District. Hotwire partners with top-of-the-line car rental companies to bring you a large selection of affordable options. Whether you’re in need of a large SUV for the entire family or a more compact but stylish vehicle, Hotwire has you covered. You can even save up to 60% off a car rental deal if you book a Hotwire Hot Rate at the last minute.

Is it safe to travel to Medical Center District now?

With recent COVID-19 closures and reopenings, many people are wondering, “Is it safe to travel to Medical Center District right now?” When it’s time to book your getaway, be sure to check out the most up-to-date information on all safety measures, any restrictions, and guidance on traveling during the coronavirus pandemic.