Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Los Osos Vacations

Pack those stellar shades. We have Los Osos vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Los Osos – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Los Osos vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Los Osos

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Los Osos vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Los Osos well.

Top Hotel Deals

See all 461 Hotels in Los Osos
Sea Pines Resort

Sea Pines Resort

1945 Solano Street, Los Osos
    3.0 out of 5.0
     
     

    Situated in Baywood-Los Osos, this golf resort is 1.1 mi (1.8 km) from Morro Coast Audubon Society Sweet Springs Nature Preserve and within 3 mi (5 km) of Los ...

    Back Bay Inn

    Back Bay Inn

    1391 Second Street, Los Osos
      3.5 out of 5.0
       
       

      Located in Baywood Park, this bed & breakfast is 0.5 mi (0.8 km) from Morro Coast Audubon Society Sweet Springs Nature Preserve and 2.4 mi (3.9 km) from Morro ...

      La Bellasera Hotel And Suites

      La Bellasera Hotel And Suites

      206 Alexa Ct, Paso Robles
        4.0 out of 5.0
         
         

        Situated in a rural location, this romantic resort is within 2 mi (3 km) of Peachy Canyon Winery, Windward Vineyard, and Castoro Cellars Winery. Anglim Winery ...

        SeaCrest OceanFront Hotel

        SeaCrest OceanFront Hotel

        2241 Price Street, Pismo Beach
          3.5 out of 5.0
           
           

          This retro chic Pismo Beach hotel is located on California's Central Coast in the Five Cities area, overlooking the Pacific Ocean.

          SeaCrest OceanFront Hotel$142

          SeaCrest OceanFront Hotel$142
          Madonna Inn

          Madonna Inn

          100 Madonna Road, San Luis Obispo
            3.5 out of 5.0
             
             

            Madonna Inn is set on a 1,000-acre estate on Highway 101, an easy drive from many Central Coast wineries. Guests can reach Avila Beach in 15 minutes by car, ...

            Madonna Inn$109

            Madonna Inn$109
            La Cuesta Inn

            La Cuesta Inn

            2074 Monterey Street, San Luis Obispo
              2.5 out of 5.0
               
               

              Situated in San Luis Obispo, this hotel is within 1 mi (2 km) of Fremont Theater and Mission San Luis Obispo de Tolosa. Performing Arts Center and Dallidet Adobe ...

              La Cuesta Inn$139

              La Cuesta Inn$139
              Cottage Inn By The Sea

              Cottage Inn By The Sea

              2351 Price St, Pismo Beach
                3.0 out of 5.0
                 
                 

                Set on a bluff overlooking Pismo Beach and the Pacific Ocean, this renovated English country-style inn provides convenient access to the 1,100-foot-long (335-meter-long) ...

                Cottage Inn By The Sea$125

                Cottage Inn By The Sea$125
                Oxford Suites Pismo Beach

                Oxford Suites Pismo Beach

                651 Five Cities Dr, Pismo Beach
                  2.5 out of 5.0
                   
                   

                  The golden sands of Pismo Beach are a 5-minute drive from this cozy hotel. Travelers in need of retail therapy can walk 10 minutes to Pismo Beach Premium Outlets. ...

                  Oxford Suites Pismo Beach$105

                  Oxford Suites Pismo Beach$105
                  Shore Cliff Hotel

                  Shore Cliff Hotel

                  2555 Price Street, Pismo Beach
                    3.0 out of 5.0
                     
                     

                    Located in the heart of Pismo Beach, this hotel is within 1 mi (2 km) of Margo Dodd Park and Pismo Beach Pier. North Beach Campground and Pismo Beach Prime Outlets ...

                    Shore Cliff Hotel$159

                    Shore Cliff Hotel$159
                    La Serena Inn

                    La Serena Inn

                    990 Morro Avenue, Morro Bay
                      2.5 out of 5.0
                       
                       

                      Situated in Morro Bay, this hotel is within 1 mi (2 km) of Morro Bay Skateboard Museum and Morro Rock. Morro Bay State Park is 2.9 mi (4.7 km) away.

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.