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Santa Cruz

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Santa Cruz Flights as Low as $442

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

Boliviana De Aviacion
Boliviana De Aviacion
LATAM Airlines Group
LATAM Airlines Group
Boliviana De Aviacion
Boliviana De Aviacion
LATAM Airlines Group
avianca
Boliviana De Aviacion
avianca
LATAM Airlines Group
Boliviana De Aviacion
Boliviana De Aviacion
Aerolineas Argentinas
LATAM Airlines Group
United

Cheap Flights to Santa Cruz

Fall in love at first flight with your vacation to Santa Cruz by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Santa Cruz on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Santa Cruz, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Santa Cruz

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Santa Cruz with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the SRZ airport.

What is the cheapest month to fly to Santa Cruz?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Santa Cruz are in March, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Santa Cruz?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Santa Cruz.

What airport is best to fly into Santa Cruz?

When you’re planning your trip to Santa Cruz, convenience is the name of the game. Luckily, Santa Cruz El Trompillo Airport is nearby so you can deplane and get going on checking off everything on your Santa Cruz must-do list.

How much are flights to Santa Cruz?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Santa Cruz on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $442, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Santa Cruz?

The trick to saving a stack of cash on your flight to Santa Cruz? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $442 right now, why wait?

Santa Cruz Flight Information
Destination airport
Viru Viru Intl.
Destination airport IATA code
VVI
Roundtrip price
$701

Last Minute Hotel Deals in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (261 reviews)
"Beautiful views and clean property. The food there is great, and it’s well located. However, the cleaning staff stole a $100 bill from my backpack and replaced it with a fake one. I would rather they just took the money, but replacing it with a fake note could’ve gotten me in serious trouble, and ..."

Reviewed on Oct 30, 2026

Marriott Santa Cruz de la Sierra Hotel
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

5 out of 5
AV ROCA CORONADO 901 Santa Cruz
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Parque Ecológico and Patio Design LifeStyle ...
Novotel Santa Cruz De La Sierra
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
Sun Hotel
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
Camino Real Hotel
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E Santa Cruz
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
9.2/10 Wonderful! (296 reviews)
"Excelente servicio! La próxima visita nos quedaremos más tiempo."

Reviewed on Nov 14, 2026

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este Santa Cruz
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (186 reviews)
"Habitaciones y todas las instalaciones estaban limpias, personal muy amable y atento. Ubicado en equipetrol con todo cerca"

Reviewed on Oct 31, 2026

TRYP by Wyndham Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Hotels With Free Airport Shuttle

Casa Vida

Casa Vida

3.5 out of 5
Condominio Club Campestre Santa Cruz Santa
Book a stay at this family-friendly vacation home in Santa Cruz. Enjoy free WiFi, free parking, and private hot tubs.
9/10 Wonderful! (2 reviews)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"

Reviewed on Sep 28, 2017

Casa Vida
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
Sun Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.