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Hotels in Santa Cruz

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Choose from 290 Santa Cruz Hotel Deals

Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
  • 5 min drive from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
9/10 Wonderful! (420 reviews)
Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options.

Reviewed on Feb 5, 2026

Camino Real Hotel
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
  • 16 min walk from Plaza 24 de Septiembre
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.6/10 Exceptional! (95 reviews)
Good

Reviewed on Mar 8, 2026

Ibis Santa Cruz DE LA Sierra
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
  • 28 min walk from Plaza 24 de Septiembre
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (364 reviews)
Yes

Reviewed on Mar 8, 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (220 reviews)
Mattress was hard, pillows flattened, no microwave and fridge was not cooling. Other than that, the personnel were 5 stars, friendly attentive and respectful.

Reviewed on Mar 1, 2026

Marriott Santa Cruz de la Sierra Hotel
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
  • 21 min drive from Plaza 24 de Septiembre
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (353 reviews)
Very close to the airport Room is so quiet and comfortable

Reviewed on Mar 20, 2026

Sun Hotel
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

5 out of 5
AV ROCA CORONADO 901 Santa Cruz
  • 21 min walk from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Parque Ecológico and Patio Design LifeStyle ...
9.2/10 Wonderful! (109 reviews)
Quarto, restaurant, equipe

Reviewed on Mar 3, 2026

Novotel Santa Cruz De La Sierra
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
9.2/10 Wonderful! (265 reviews)
Super Clean Hotel. The Bathroom looks like a Sauna with a Central Súper Shower. The Bed has a Cloud feeling. Delicious Súper Breakfast. Highly recommended!

Reviewed on Mar 18, 2026

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
  • 29 min walk from Plaza 24 de Septiembre
Book a stay at this business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
Premium Suites Deluxe Aparthotel Equipetrol
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este Santa Cruz
  • 26 min walk from Plaza 24 de Septiembre
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
TRYP by Wyndham Santa Cruz
Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure

3.5 out of 5
Calle Pablo Sanz 29 Equipetrol Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
Stay at this hotel in Santa Cruz. Enjoy free WiFi, room service, and daily housekeeping. Popular attractions Ventura Mall and Santa Cruz Zoo are located ...
9/10 Wonderful! (84 reviews)
Yes room was tidy and clean. Beds were very comfortable

Reviewed on Feb 17, 2026

Delfines Collection Hotel By Mercure
Hotel Cortez

Hotel Cortez

3.5 out of 5
Av. Cristobal de Mendoza 280 Santa Cruz
  • 16 min walk from Plaza 24 de Septiembre
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Municipal Library and Centro Cultural Ronald ...
Hotel Cortez
Hotel Las Américas

Hotel Las Américas

3 out of 5
Calle 21 de Mayo esq, Seoane N 356 Santa Cruz Santa Cruz Department
  • 4 min walk from Plaza 24 de Septiembre
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions La Recova Artisan Walk and Guarani Nandereko ...
Hotel Las Américas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santa Cruz

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Frequently Asked Questions About Santa Cruz hotels

Where can I find the best last-minute travel deals?

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How many hotels are there in Santa Cruz?

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