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Hotels in Santa Cruz

Choose from 292 Santa Cruz Hotel Deals

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
  • 16 min walk from Plaza 24 de Septiembre
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (72 reviews)
everything was perfect 👌

Reviewed on Nov 27, 2025

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (210 reviews)
The greeting employees at the entrancing the building and the restaurant employees, very friendly. Thank you

Reviewed on Nov 10, 2025

Marriott Santa Cruz de la Sierra Hotel
Hotel Las Américas

Hotel Las Américas

3 out of 5
Calle 21 de Mayo esq, Seoane N 356 Santa Cruz Santa Cruz Department
  • 4 min walk from Plaza 24 de Septiembre
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions La Recova Artisan Walk and Guarani Nandereko ...
6/10 (1 review)
Hotel mediano, ótima localização
O chuveiro foi impossível tomar um.banho de qualidade

Reviewed on Jul 29, 2025

Hotel Las Américas
Sun Hotel

Sun Hotel

3.5 out of 5
Av. Banzer Km 13 Santa Cruz Santa Cruz
  • 21 min drive from Plaza 24 de Septiembre
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very Good! (329 reviews)
Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok

Reviewed on Nov 16, 2025

Sun Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
  • 28 min walk from Plaza 24 de Septiembre
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.8/10 Excellent! (343 reviews)
Wonderful staff with beautiful pool area and amenities. Great restaurant too.

Reviewed on Nov 28, 2025

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

4 out of 5
Av. San Martin, Calle 9 Este Santa Cruz
  • 26 min walk from Plaza 24 de Septiembre
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (144 reviews)
Personel not too friendly

Reviewed on Nov 28, 2025

TRYP by Wyndham Santa Cruz
Camino Real Hotel

Camino Real Hotel

4.5 out of 5
Av. San Martín y 4to. Anillo Santa Cruz
  • 5 min drive from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Santa Cruz ...
8.8/10 Excellent! (407 reviews)
Excellent hotel, I willl always used it in this location

Reviewed on Dec 1, 2025

Camino Real Hotel
Hotel Cortez

Hotel Cortez

3.5 out of 5
Av. Cristobal de Mendoza 280 Santa Cruz
  • 17 min walk from Plaza 24 de Septiembre
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Municipal Library and Arenal Park are located ...
9/10 Wonderful! (121 reviews)
The staff and property are second to none!

Reviewed on Jun 14, 2025

Hotel Cortez
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 out of 5
San Martin Avenue Esq Street E - E Santa Cruz
  • 4 min drive from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Ventura Mall and Patio Design LifeStyle ...
9.2/10 Wonderful! (253 reviews)
Our room was clean and comfortable. The staff were friendly and very helpful!

Reviewed on Oct 25, 2025

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

5 out of 5
AV ROCA CORONADO 901 Santa Cruz
  • 21 min walk from Plaza 24 de Septiembre
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Parque Ecológico and Patio Design LifeStyle ...
9/10 Wonderful! (103 reviews)
YES!! i WANT TO COMEBACK TO THIS LOCATION
Fantastic people, very friendly. The hotel was clean, and everything was great. I would pick this hotel anytime.

Reviewed on Sep 26, 2025

Novotel Santa Cruz De La Sierra
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
  • 29 min walk from Plaza 24 de Septiembre
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (92 reviews)
Everything is perfect!!

Reviewed on Oct 29, 2025

Apart Hotel Premium Suites Santa Cruz
HOTEL OSHO

HOTEL OSHO

3.5 out of 5
751 Ave Suarez Arana Santa Cruz Departamento de Santa Cruz
  • 16 min walk from Plaza 24 de Septiembre
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and an outdoor pool. Popular attractions Santa Cruz de la Sierra ...
9/10 Wonderful! (31 reviews)
Fantastic. All clean I can said is the best hotel in Santa Cruz.

Reviewed on Nov 25, 2025

HOTEL OSHO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find cheap hotels in Santa Cruz

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