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Hartsville

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Hartsville Flights as Low as $387

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Sat, Jul 5 - Mon, Jul 7
SAT
San Antonio Intl.
FLO
Florence Regional
$387 Roundtrip, found 23 hours ago
$387
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Jul 5 from San Antonio Intl. to Florence Regional, returning Mon, Jul 7, priced at $387 found 23 hours ago
American Airlines
Fri, Jul 4 - Mon, Jul 7
SAT
San Antonio Intl.
FLO
Florence Regional
$392 Roundtrip, found 23 hours ago
$392
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Florence Regional, returning Mon, Jul 7, priced at $392 found 23 hours ago
American Airlines
Fri, Jul 4 - Sat, Jul 12
SAT
San Antonio Intl.
FLO
Florence Regional
$397 Roundtrip, found 23 hours ago
$397
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Florence Regional, returning Sat, Jul 12, priced at $397 found 23 hours ago
American Airlines
Wed, Jul 2 - Mon, Jul 7
SAT
San Antonio Intl.
FLO
Florence Regional
$448 Roundtrip, found 23 hours ago
$448
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Jul 2 from San Antonio Intl. to Florence Regional, returning Mon, Jul 7, priced at $448 found 23 hours ago
American Airlines
Wed, Jul 2 - Sat, Jul 12
SAT
San Antonio Intl.
FLO
Florence Regional
$453 Roundtrip, found 23 hours ago
$453
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Jul 2 from San Antonio Intl. to Florence Regional, returning Sat, Jul 12, priced at $453 found 23 hours ago
American Airlines
Fri, Jul 4 - Sun, Jul 6
SAT
San Antonio Intl.
FLO
Florence Regional
$473 Roundtrip, found 23 hours ago
$473
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Florence Regional, returning Sun, Jul 6, priced at $473 found 23 hours ago
American Airlines
Mon, Jul 7 - Sat, Jul 12
SAT
San Antonio Intl.
FLO
Florence Regional
$478 Roundtrip, found 23 hours ago
$478
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Mon, Jul 7 from San Antonio Intl. to Florence Regional, returning Sat, Jul 12, priced at $478 found 23 hours ago
American Airlines
Thu, Jul 3 - Mon, Jul 7
SAT
San Antonio Intl.
FLO
Florence Regional
$520 Roundtrip, found 23 hours ago
$520
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Jul 3 from San Antonio Intl. to Florence Regional, returning Mon, Jul 7, priced at $520 found 23 hours ago
American Airlines
Thu, Jul 3 - Sat, Jul 12
SAT
San Antonio Intl.
FLO
Florence Regional
$525 Roundtrip, found 23 hours ago
$525
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Jul 3 from San Antonio Intl. to Florence Regional, returning Sat, Jul 12, priced at $525 found 23 hours ago
American Airlines
Sat, Jul 5 - Sun, Jul 13
SAT
San Antonio Intl.
FLO
Florence Regional
$531 Roundtrip, found 23 hours ago
$531
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Jul 5 from San Antonio Intl. to Florence Regional, returning Sun, Jul 13, priced at $531 found 23 hours ago
American Airlines
Wed, Jul 2 - Sun, Jul 6
SAT
San Antonio Intl.
FLO
Florence Regional
$534 Roundtrip, found 23 hours ago
$534
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Jul 2 from San Antonio Intl. to Florence Regional, returning Sun, Jul 6, priced at $534 found 23 hours ago
American Airlines
Fri, Jul 4 - Sun, Jul 13
SAT
San Antonio Intl.
FLO
Florence Regional
$536 Roundtrip, found 23 hours ago
$536
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Fri, Jul 4 from San Antonio Intl. to Florence Regional, returning Sun, Jul 13, priced at $536 found 23 hours ago
American Airlines
Wed, Jul 2 - Sun, Jul 13
SAT
San Antonio Intl.
FLO
Florence Regional
$592 Roundtrip, found 23 hours ago
$592
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Jul 2 from San Antonio Intl. to Florence Regional, returning Sun, Jul 13, priced at $592 found 23 hours ago
American Airlines
Thu, Jul 3 - Sun, Jul 6
SAT
San Antonio Intl.
FLO
Florence Regional
$606 Roundtrip, found 23 hours ago
$606
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Jul 3 from San Antonio Intl. to Florence Regional, returning Sun, Jul 6, priced at $606 found 23 hours ago
American Airlines
Mon, Jul 7 - Sun, Jul 13
SAT
San Antonio Intl.
FLO
Florence Regional
$617 Roundtrip, found 23 hours ago
$617
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Mon, Jul 7 from San Antonio Intl. to Florence Regional, returning Sun, Jul 13, priced at $617 found 23 hours ago
American Airlines
Thu, Jul 3 - Sun, Jul 13
SAT
San Antonio Intl.
FLO
Florence Regional
$664 Roundtrip, found 23 hours ago
$664
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Jul 3 from San Antonio Intl. to Florence Regional, returning Sun, Jul 13, priced at $664 found 23 hours ago

Cheap Flights to Hartsville

Fall in love at first flight with your vacation to Hartsville by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Hartsville on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Hartsville, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Hartsville

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Hartsville with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the FLO airport.

What is the cheapest month to fly to Hartsville?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Hartsville are in July, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Hartsville?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Hartsville.

What airport is best to fly into Hartsville?

When you’re planning your trip to Hartsville, convenience is the name of the game. Luckily, Hartsville Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Hartsville must-do list.

How much are flights to Hartsville?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Hartsville on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $387, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Hartsville?

The trick to saving a stack of cash on your flight to Hartsville? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $387 right now, why wait?

Hartsville Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$386

Last Minute Hotel Deals in Hartsville

Fairfield Inn by Marriott Hartsville
Fairfield Inn by Marriott Hartsville
2.5 out of 5
200 S 4th St, Hartsville, SC
The price is $115 per night from May 11 to May 12
$115
includes taxes & fees
May 11 - May 12
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (622 reviews)
Grudge Race Weekend Trip Darlington
"The hotel was very clean and staff were friendly and helpful with any questions or concerns."

Reviewed on Apr 21, 2025

Fairfield Inn by Marriott Hartsville
The Landmark Inn
The Landmark Inn
2.5 out of 5
1301 South 4th Street, Hartsville, SC
The price is $79 per night from May 4 to May 5
$79
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly motel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7/10 Good! (282 reviews)
One nighter
"Room was clean but needed a better comforter."

Reviewed on Apr 21, 2025

The Landmark Inn
Quality Inn
Quality Inn
2.5 out of 5
903 S 5th Street, Hartsville, SC
The price is $63 per night from May 21 to May 22
$63
includes taxes & fees
May 21 - May 22
Book a stay at this business-friendly hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Hartsville Museum and Hartsville ...
6/10 (281 reviews)
"Good place for staying"

Reviewed on Apr 26, 2025

Quality Inn
The Mantissa Hotel
The Mantissa Hotel
3 out of 5
130 East Carolina Ave, Hartsville, SC
The price is $201 per night from May 4 to May 5
$201
includes taxes & fees
May 4 - May 5
Stay at this 3-star hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (233 reviews)
"This property is a gem! I would recommend this hotel to anyone that would fins themselves in the Hartsville/Darlington area!"

Reviewed on Apr 6, 2025

The Mantissa Hotel
Hampton Inn & Suites Hartsville
Hampton Inn & Suites Hartsville
2.5 out of 5
203 East Carolina Ave., Hartsville, SC
The price is $148 per night from May 26 to May 27
$148
includes taxes & fees
May 26 - May 27
Stay at this hotel in Hartsville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.2/10 Wonderful! (439 reviews)
"clean rooms"

Reviewed on Apr 28, 2025

Hampton Inn & Suites Hartsville
Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham Florence
2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
The price is $73 per night from May 4 to May 5
$73
includes taxes & fees
May 4 - May 5
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
8.6/10 Excellent! (2,196 reviews)
"The property was conveniently located to 95 for an overnight stay"

Reviewed on May 1, 2025

Howard Johnson by Wyndham Florence
Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SC
2.5 out of 5
1729 Mandeville Road, Florence, SC
The price is $94 per night from May 26 to May 27
$94
includes taxes & fees
May 26 - May 27
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
9/10 Wonderful! (2,045 reviews)
"Staff was very pleasant and friendly. Hotel was clean and breakfast was decent. Great hotel for the price."

Reviewed on May 1, 2025

Park Inn by Radisson Florence, SC
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
The price is $93 per night from Jun 1 to Jun 2
$93
includes taxes & fees
Jun 1 - Jun 2
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,201 reviews)
Pet friendly
"It was just an overnight stop on a longer trip. We had our dog so it was pet friendly. We were very pkeased"

Reviewed on Apr 30, 2025

Quality Inn & Suites Florence Civic Center
See all 152 properties in Hartsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.