Search Deals onWykoff Vacation Packages
Wykoff Flight + Hotel Packages
Price found within the past 48 hours. Click for updated prices.
Hyatt House Rochester/Mayo Clinic Area
Price was $368, price is now $317 per person
$317
per person
Jan 7 - Jan 10
found 6 hours ago
Roundtrip flight included
Dallas (DFW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Shops University Square are located nearby.
This is a hotel that due to its proximity to Mayo Clinic has a unique clientele and everyone there is so kind and considerate and extremely helpful. I highly recommend this property. The pool/hot tub setup is very pleasant after a long day at the hospital. It’s also very safe and accessible.
Reviewed on Nov 15, 2026
Kahler Inn and Suites - Mayo Clinic Area
Price was $355, price is now $320 per person
$320
per person
Jan 7 - Jan 10
found 6 hours ago
Roundtrip flight included
Dallas (DFW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mayo Civic Center and Plummer Building are located nearby.
Kahler Grand Hotel
Price was $351, price is now $318 per person
$318
per person
Jan 7 - Jan 10
found 6 hours ago
Roundtrip flight included
Dallas (DFW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mayo Civic Center and Plummer Building are located nearby.
It was good
Reviewed on Nov 15, 2026
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
Price was $744, price is now $684 per person
$684
per person
Dec 23 - Dec 27
found 14 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the helpful staff in our reviews. Popular attractions Mayo Civic Center and Kutzky Park Tennis Center are located nearby.
Clean, spacious and very modern. Would definitely stay here again.
Reviewed on Nov 6, 2026
Holiday Inn Express Rochester South - Mayo Area by IHG
Price was $738, price is now $687 per person
$687
per person
Dec 23 - Dec 27
found 14 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Marcus Rochester Cinema are located nearby.
This hotel is conveniently located , very well maintained. It also features a very nice breakfast bar with hot items ,lots of fresh fruit , yogurts etc.. With future visits this hotel will probably be our first choice for accommodations..
Reviewed on Nov 14, 2026
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Price was $771, price is now $718 per person
$718
per person
Dec 23 - Dec 27
found 14 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free parking, and a free area shuttle. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mayo Civic Center and Kutzky Park Tennis Center are located nearby.
Spark by Hilton Rochester South
Price was $681, price is now $637 per person
$637
per person
Dec 23 - Dec 27
found 14 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Mayo Civic Center and Marcus Rochester Cinema are located nearby.
Very clean. Quiet. Turned air conditioner off and heat on. Only complaint I had was the toilet seat needed to be tightened down. Would slide around every time you sit down.
Reviewed on Nov 14, 2026
The Berkman
Price was $959, price is now $900 per person
$900
per person
Dec 23 - Dec 27
found 14 hours ago
Roundtrip non-stop flight included
Detroit (DTW) to Rochester (RST)
Book a stay at this golf aparthotel in Rochester. Enjoy free WiFi, an outdoor pool, and a rooftop terrace. Our guests praise the helpful staff in our reviews. Popular attractions Mayo Civic Center and Kutzky Park Tennis Center are located nearby.
Wykoff Vacation Packages 3-4 Night Stays
Price found within the past 48 hours. Click for updated prices.
Top Flight Deals
Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.
Wed, Jan 20 - Tue, Feb 9
IND
Indianapolis Intl.
RST
Rochester Intl.
$396 Roundtrip, found 3 days ago
$396
Roundtrip
found 3 days ago
Sat, Dec 12 - Thu, Dec 17
ORD
O'Hare Intl.
RST
Rochester Intl.
$408 Roundtrip, found 3 days ago
$408
Roundtrip
found 3 days ago
Mon, Nov 16 - Mon, Nov 23
DTW
Detroit Metropolitan Wayne County
RST
Rochester Intl.
$439 Roundtrip, found 2 days ago
$439
Roundtrip
found 2 days ago
Sat, Dec 12 - Thu, Dec 17
ORD
O'Hare Intl.
RST
Rochester Intl.
$481 Roundtrip, found 3 days ago
$481
Roundtrip
found 3 days ago
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