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Santa Cruz
Chiriquí Province
Panama
Mexico and Central America
Hotwire.com

Santa Cruz Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Riande Aeropuerto Hotel & Casino

4 out of 5

Price was $996, price is now $714 per person

$714

per person

Jul 19 - Jul 22

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,612, price is now $954 per person

$954

per person

Sep 3 - Sep 7

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Las Clementinas

3.5 out of 5

Price was $1,720, price is now $1,151 per person

$1,151

per person

Aug 11 - Aug 18

found 10 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this aparthotel in Panama City. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,142, price is now $778 per person

$778

per person

Jul 19 - Jul 22

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Hotel Riu Plaza Panama

5 out of 5

Price was $1,046, price is now $771 per person

$771

per person

Jul 19 - Jul 22

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Casa Lefevre By Wynwood House

3.5 out of 5

Price was $1,258, price is now $951 per person

$951

per person

Aug 26 - Aug 31

found 23 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

La Cuadra by Wynwood House

3 out of 5

Price was $1,318, price is now $1,000 per person

$1,000

per person

Jul 15 - Jul 21

found 1 day ago

Roundtrip flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Stay at this condo in Panama City. Enjoy free WiFi, a 24-hour front desk, and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Mini Design By Wynwood House

3 out of 5

Price was $1,321, price is now $1,022 per person

$1,022

per person

Jul 24 - Jul 31

found 10 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, air conditioning, and an outdoor pool. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.