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Picayune Vacations

Pack those stellar shades. We have Picayune vacation deals for you!

If there’s one thing you should spend in this busy world, it’s your vacation days. We know it’s easy to hang onto them, but Hotwire votes for putting them to use. It’s time to let an adventure lead you away from the daily grind. Stock up on what really matters on your trip to Picayune – great memories and a tall tale or two.

Hotwire can help you find your travel bliss with Picayune vacation packages. Bundling your hotel, car and flight means more unexpected fun with the money you saved. We’ll cover the bases; now it’s time for you to get up and go!

Pack everything you want – then take half of it out

We mean it. It’s far too easy to over-pack. We recommend picking your essentials and washing them along the way. Then you’ll have room for that goofy souvenir you know you want – or for some new outfits from that cute boutique you discover.

Bring comfortable walking shoes on your trip to Picayune

No one should have to endure walking tours in dress shoes or high heels. No one.

Bring photocopies of your passport or license

You flew home from a great Picayune vacation but your most important documents stayed behind. We’ve heard that story before and recommend keeping an extra copy on hand – just in case. Hey, at least it wasn’t a family member.

Don’t underestimate the power of earplugs

Among crying babies, rowdy crowds and honking horns, take our word for it. One pair can save you from the zombie-like state of a sleepless night.

Always carry some cash

You’ll be ready for anything from an evil ATM to lost credit cards. Holding a little extra cash in your wallet and carry-on means you can breathe easy if anything unexpected pops up.

Explore like a local

Guidebooks and maps are great for getting an overview of the place, but to really dig in, go where the locals go. Pick up a newspaper or city magazine to see what restaurants and neighborhoods are hot. Check events listings and go see a band or attend a street festival. Or ask your friends for recommendations. You’d be surprised who in your circle knows Picayune well.

Top Hotel Deals

See all 107 Properties in Picayune
Heritage Inn Picayune

Heritage Inn Picayune

1122 Memorial Blvd., Picayune
    2.0 out of 5.0
     
     

    Situated in Picayune, this hotel is 1.6 mi (2.5 km) from Crosby Aboretum and 4.3 mi (7 km) from Millbrook Country Club. John C. Stennis Space Center and Lazy ...

    Heritage Inn Picayune$65

    Heritage Inn Picayune$65
    Super 8 by Wyndham Picayune

    Super 8 by Wyndham Picayune

    999 Cooper Road, Picayune
      2.0 out of 5.0
       
       

      Located in the heart of Picayune, this motel is 2 mi (3.2 km) from Millbrook Country Club and 3.9 mi (6.3 km) from Crosby Aboretum. John C. Stennis Space Center ...

      Super 8 by Wyndham Picayune$42

      Super 8 by Wyndham Picayune$42
      Days Inn by Wyndham Picayune

      Days Inn by Wyndham Picayune

      450 S Lofton Avenue , Picayune
        2.0 out of 5.0
         
         

        Situated in Picayune, this motel is 1.7 mi (2.8 km) from Crosby Aboretum and 4.8 mi (7.7 km) from Millbrook Country Club. John C. Stennis Space Center and Lazy ...

        Days Inn by Wyndham Picayune$75

        Days Inn by Wyndham Picayune$75
        Econo Lodge Picayune

        Econo Lodge Picayune

        550 S Lofton, Picayune
          2.0 out of 5.0
           
           

          Situated in Picayune, this hotel is 1.9 mi (3.1 km) from Crosby Aboretum and 3.7 mi (5.9 km) from Millbrook Country Club. John C. Stennis Space Center and Lazy ...

          Econo Lodge Picayune$69

          Econo Lodge Picayune$69
          Holiday Inn Express Picayune-Stennis Space Center

          Holiday Inn Express Picayune-Stennis Space Center

          1001 Dauphin Street, Picayune
            2.5 out of 5.0
             
             

            Situated in Picayune, this hotel is 2 mi (3.3 km) from Crosby Aboretum and 3.8 mi (6.1 km) from Millbrook Country Club. John C. Stennis Space Center and Lazy ...

            Holiday Inn Express Picayune-Stennis Space Center$85

            Holiday Inn Express Picayune-Stennis Space Center$85
            La Quinta Inn New Orleans - Slidell

            La Quinta Inn New Orleans - Slidell

            794 E I 10 Service Rd, Slidell
              2.5 out of 5.0
               
               

              Situated in the suburbs, this hotel is 5.7 mi (9.1 km) from Honey Island Swamp and within 20 mi (32 km) of Infinity Science Center and John C. Stennis Space ...

              La Quinta Inn New Orleans - Slidell$55

              La Quinta Inn New Orleans - Slidell$55
              Microtel Inn & Suites by Wyndham Pearl River/Slidell

              Microtel Inn & Suites by Wyndham Pearl River/Slidell

              63537 Highway 1090, Pearl River
                2.5 out of 5.0
                 
                 

                Situated in Pearl River, this hotel is 11.1 mi (17.8 km) from Honey Island Swamp and 11.5 mi (18.5 km) from Oak Harbor Golf Club. Hancock County Welcome Center ...

                Microtel Inn & Suites by Wyndham Pearl River/Slidell$40

                Microtel Inn & Suites by Wyndham Pearl River/Slidell$40
                Silver Slipper Casino Hotel

                Silver Slipper Casino Hotel

                5000 South Beach Boulevard, Bay St Louis
                  3.5 out of 5.0
                   
                   

                  This Bay St Louis hotel is on the beach, 2 mi (3.3 km) from Buccaneer State Park, and within 9 mi (15 km) of Saint Stanislaus College and Bay St. Louis Little ...

                  Silver Slipper Casino Hotel$249

                  Silver Slipper Casino Hotel$249
                  Motel 6 New Orleans - Slidell

                  Motel 6 New Orleans - Slidell

                  136 Taos St, Slidell
                    2.0 out of 5.0
                     
                     

                    Situated in Slidell, this motel is 6.2 mi (9.9 km) from Honey Island Swamp and 11.6 mi (18.7 km) from Infinity Science Center. John C. Stennis Space Center and ...

                    Motel 6 New Orleans - Slidell$45

                    Motel 6 New Orleans - Slidell$45
                    Hollywood Casino Gulf Coast

                    Hollywood Casino Gulf Coast

                    711 Hollywood Blvd, Bay St Louis
                      3.5 out of 5.0
                       
                       

                      Situated near the bay, this spa resort is within 2 mi (3 km) of 100 Men D.B.A. Hall, Bay St. Louis Little Theater, and Saint Stanislaus College. Bay Saint Louis ...

                      Hollywood Casino Gulf Coast$79

                      Hollywood Casino Gulf Coast$79

                      Top Flight Deals

                      Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.