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Lake City

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Lake City Flights as Low as $363

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Sat, Aug 16 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$363 Roundtrip, found 7 hours ago
$363
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Aug 16 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $363 found 7 hours ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$366 Roundtrip, found 6 hours ago
$366
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $366 found 6 hours ago
American Airlines
Tue, Aug 12 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$368 Roundtrip, found 7 hours ago
$368
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Aug 12 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $368 found 7 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
TTN
Mercer
FLO
Florence Regional
$389 Roundtrip, found 10 hours ago
$389
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Oct 7 from Mercer to Florence Regional, returning Sat, Oct 11, priced at $389 found 10 hours ago
American Airlines
Fri, Aug 15 - Mon, Aug 18
LGA
LaGuardia
FLO
Florence Regional
$393 Roundtrip, found 7 hours ago
$393
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Fri, Aug 15 from LaGuardia to Florence Regional, returning Mon, Aug 18, priced at $393 found 7 hours ago
American Airlines
Sat, Aug 16 - Mon, Aug 18
LGA
LaGuardia
FLO
Florence Regional
$400 Roundtrip, found 7 hours ago
$400
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Sat, Aug 16 from LaGuardia to Florence Regional, returning Mon, Aug 18, priced at $400 found 7 hours ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$402 Roundtrip, found 3 days ago
$402
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $402 found 3 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$402 Roundtrip, found 3 days ago
$402
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $402 found 3 days ago
American Airlines
Fri, Aug 15 - Tue, Aug 19
LGA
LaGuardia
FLO
Florence Regional
$406 Roundtrip, found 7 hours ago
$406
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Fri, Aug 15 from LaGuardia to Florence Regional, returning Tue, Aug 19, priced at $406 found 7 hours ago
American Airlines
Wed, Oct 8 - Mon, Oct 13
TTN
Mercer
FLO
Florence Regional
$409 Roundtrip, just found
$409
Roundtrip
just found
Select American Airlines flight, departing Wed, Oct 8 from Mercer to Florence Regional, returning Mon, Oct 13, priced at $409 just found
American Airlines
Tue, Aug 12 - Thu, Aug 21
LGA
LaGuardia
FLO
Florence Regional
$416 Roundtrip, found 7 hours ago
$416
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Tue, Aug 12 from LaGuardia to Florence Regional, returning Thu, Aug 21, priced at $416 found 7 hours ago
American Airlines
Wed, Jul 16 - Sun, Jul 20
LGA
LaGuardia
FLO
Florence Regional
$432 Roundtrip, found 3 days ago
$432
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Jul 16 from LaGuardia to Florence Regional, returning Sun, Jul 20, priced at $432 found 3 days ago
American Airlines
Tue, Oct 7 - Sat, Oct 11
PHL
Philadelphia Intl.
FLO
Florence Regional
$436 Roundtrip, found 3 days ago
$436
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Oct 7 from Philadelphia Intl. to Florence Regional, returning Sat, Oct 11, priced at $436 found 3 days ago
American Airlines
Tue, Jul 15 - Wed, Jul 23
LGA
LaGuardia
FLO
Florence Regional
$437 Roundtrip, found 6 hours ago
$437
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Jul 15 from LaGuardia to Florence Regional, returning Wed, Jul 23, priced at $437 found 6 hours ago
American Airlines
Wed, Jul 16 - Mon, Jul 21
LGA
LaGuardia
FLO
Florence Regional
$437 Roundtrip, found 5 days ago
$437
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Jul 16 from LaGuardia to Florence Regional, returning Mon, Jul 21, priced at $437 found 5 days ago
American Airlines
Fri, Aug 15 - Mon, Aug 18
LGA
LaGuardia
FLO
Florence Regional
$444 Roundtrip, found 7 hours ago
$444
Roundtrip
found 7 hours ago
Select American Airlines flight, departing Fri, Aug 15 from LaGuardia to Florence Regional, returning Mon, Aug 18, priced at $444 found 7 hours ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in August, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $363, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $363 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$362

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads
The Inn at the Crossroads
2 out of 5
128 West Main Street, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (734 reviews)
"Like location . Elevator not working gave me a challenge"

Reviewed on Jul 9, 2025

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The Inn at the Crossroads
Quality Inn & Suites
Quality Inn & Suites
2.5 out of 5
202 N Ron Mcnair Blvd, Lake City, SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7/10 Good! (154 reviews)
"Stayed here only because all hotels in Florence SC, our intended destination were booked. Checked in after 11PM, didn't even enter in lobby, but passed my ID through to the employee on duty, who, in turn, passed me the keys. Room was clean, and provided a place to sleep for 7 hours before leaving ..."

Reviewed on Feb 27, 2025

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Quality Inn & Suites
Days Inn by Wyndham Lake City
Days Inn by Wyndham Lake City
2 out of 5
170 S Ron Mcnair Blvd, Lake City, SC
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.4/10 (237 reviews)
"Overall good stay for 1 night."

Reviewed on Jun 27, 2025

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Days Inn by Wyndham Lake City
Security inn & suites
Security inn & suites
2 out of 5
319 Sumter St, Lake City, SC
Stay at this hotel in Lake City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Lynches Lake Historical Society and The Bean Market ...
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Security inn & suites
Comfort Inn & Suites
Comfort Inn & Suites
2.5 out of 5
527 Woody Jones Blvd, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,027 reviews)
"one of the nicest comfort inns ive ever been to… bed was super comfortable"

Reviewed on Jul 11, 2025

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Comfort Inn & Suites
Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic Center
2.5 out of 5
150 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
7.8/10 Good! (1,226 reviews)
"More protein options at breakfast."

Reviewed on Jul 7, 2025

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Quality Inn & Suites Florence Civic Center
Days Inn by Wyndham Florence Near Civic Center
Days Inn by Wyndham Florence Near Civic Center
2.5 out of 5
140 Dunbarton Dr, Florence, SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
6.6/10 (1,001 reviews)
"I really like the location. It was close to the mall, Target, and many dining locations. The staff was so friendly and welcoming."

Reviewed on Jul 3, 2025

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Days Inn by Wyndham Florence Near Civic Center
TownePlace Suites by Marriott Florence
TownePlace Suites by Marriott Florence
3 out of 5
2650 Hospitality Boulevard, Florence, SC
Stay at this 3-star business-friendly hotel in Florence. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the helpful staff ...
8.8/10 Excellent! (608 reviews)
"Just an overnight stay until our final vacation destination.. Arrived at 225am.. The Wonderful staff checked us in seamlessly Comfortable relaxing 2BR suite"

Reviewed on Jul 10, 2025

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TownePlace Suites by Marriott Florence
See all 83 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.