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Lake City

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Lake City Flights as Low as $431

Prices found within past 7 days. Prices and availability subject to change. Additional terms may apply.

American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$431 Roundtrip, found 3 hours ago
$431
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $431 found 3 hours ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$501 Roundtrip, found 6 days ago
$501
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $501 found 6 days ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$511 Roundtrip, found 4 days ago
$511
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $511 found 4 days ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$518 Roundtrip, found 3 days ago
$518
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $518 found 3 days ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$544 Roundtrip, found 3 days ago
$544
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $544 found 3 days ago
American Airlines
Tue, Dec 22 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$548 Roundtrip, found 6 hours ago
$548
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Dec 22 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $548 found 6 hours ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$557 Roundtrip, found 4 days ago
$557
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $557 found 4 days ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$561 Roundtrip, found 3 days ago
$561
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $561 found 3 days ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$569 Roundtrip, found 6 days ago
$569
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $569 found 6 days ago
American Airlines
Tue, Dec 22 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$582 Roundtrip, found 6 hours ago
$582
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Dec 22 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $582 found 6 hours ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$585 Roundtrip, found 1 hour ago
$585
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $585 found 1 hour ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$590 Roundtrip, found 3 days ago
$590
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $590 found 3 days ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$601 Roundtrip, found 6 days ago
$601
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $601 found 6 days ago
American Airlines
Fri, Dec 25 - Thu, Dec 31
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$619 Roundtrip, found 1 hour ago
$619
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Thu, Dec 31, priced at $619 found 1 hour ago
American Airlines
Fri, Dec 25 - Wed, Dec 30
MSP
Minneapolis - St. Paul Intl.
FLO
Florence Regional
$627 Roundtrip, found 6 hours ago
$627
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Fri, Dec 25 from Minneapolis - St. Paul Intl. to Florence Regional, returning Wed, Dec 30, priced at $627 found 6 hours ago
American Airlines
Thu, Jan 21 - Thu, Jan 28
DFW
Dallas-Fort Worth Intl.
FLO
Florence Regional
$643 Roundtrip, found 6 days ago
$643
Roundtrip
found 6 days ago
Select American Airlines flight, departing Thu, Jan 21 from Dallas-Fort Worth Intl. to Florence Regional, returning Thu, Jan 28, priced at $643 found 6 days ago

Cheap Flights to Lake City

Fall in love at first flight with your vacation to Lake City by saving a ton of cash on your last-minute cheap flight. There’s no more scouring the internet for a good deal—book your flight to Lake City on Hotwire, and you’ll be up, up, and on a getaway in no time.

Because once the wheels are down in Lake City, the good times start rolling. So buckle up, you’re in for a fun ride.

Frequently Asked Questions About flights to Lake City

Don’t waste your time on endless searches for cheap airline tickets oneway or roundtrip. We’ll have you on your way to Lake City with a tiny bag of pretzels in your hand before you can say “tray tables in the upright position”—and for a ticket price that works for your vacay budget.

So all you have to worry about is where you’re headed after the ADR airport.

What is the cheapest month to fly to Lake City?

Airline ticket prices fluctuate all the time, depending on the day of the week or the month of the year. The cheapest round trip flights to Lake City are in January, but when you book your flight on Hotwire, savings are always in season.

How many airlines fly to Lake City?

Variety is the spice of life, even when it comes to booking your next trip. Want options for airlines? You’ll find 16 to choose from for your flight to Lake City.

What airport is best to fly into Lake City?

When you’re planning your trip to Lake City, convenience is the name of the game. Luckily, Lake City Florence Regional Airport is nearby so you can deplane and get going on checking off everything on your Lake City must-do list.

How much are flights to Lake City?

Got very cheap flights on your vacation itinerary? When you book your airline tickets to Lake City on Hotwire, you may just get what’s on your getaway wish list. With tickets as low as $431, you’ll have leftover cash for at least a magazine and a bottle of water at the airport book store.

How to get cheap flights to Lake City?

The trick to saving a stack of cash on your flight to Lake City? Snatch up that Hotwire flight deal when you see a killer rate because it could be gone in a flash. And with flights as low as $431 right now, why wait?

Lake City Flight Information
Destination airport
Florence Regional
Destination airport IATA code
FLO
Roundtrip price
$430

Last Minute Hotel Deals in Lake City

The Inn at the Crossroads

The Inn at the Crossroads

2 out of 5
128 West Main Street Lake City SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
9.4/10 Exceptional! (968 reviews)
"Housekeeping was very respectful and pleasant. Some hotels the interactions with housekeeping makes you don't want them in your room even while you're there. Not The Inn at Crossroads. You will love the hospitality through out the whole hotel."

Reviewed on Sep 13, 2026

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The Inn at the Crossroads
Quality Inn & Suites Lake City

Quality Inn & Suites Lake City

2.5 out of 5
202 N Ron Mcnair Blvd Lake City SC
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
7.2/10 Good! (190 reviews)
"Not the best hotel. Bathroom was dirty."

Reviewed on Sep 11, 2026

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Quality Inn & Suites Lake City
Days Inn by Wyndham Lake City

Days Inn by Wyndham Lake City

2 out of 5
170 S Ron Mcnair Blvd Lake City SC
Book a stay at this business-friendly motel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Lynches Lake Historical Society ...
6.4/10 (265 reviews)
"The person who checked-in our group was not friendly and somewhat condescending. Maybe this hotel does not have upper middle class visitors - seems to be for low income patrons - maybe illicit activity as well. For example, our request for 3 rooms on the bottom floor was not honored - we were told ..."

Reviewed on Sep 11, 2026

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Days Inn by Wyndham Lake City
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

2.5 out of 5
527 Woody Jones Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,361 reviews)
"Second time we’ve stopped at this hotel overnight and both times was a pleasant experience. The hotel is clean and our bedroom was very comfortable. We didn’t have any issues during our visits. If I had to mention something less favorable, it would be the room carpet in a pet friendly hotel. But ..."

Reviewed on Sep 12, 2026

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Comfort Inn & Suites Florence Center Area
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

2.5 out of 5
150 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
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Quality Inn & Suites Florence Civic Center
SpringHill Suites by Marriott Florence

SpringHill Suites by Marriott Florence

3 out of 5
2670 Hospitality Blvd Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the clean ...
8.2/10 Very Good! (1,000 reviews)
"We had a problem with a TV and refrigerator in one of our two rooms. The staff was excellent and replaced the items immediately so that the rest of our stay was good. The housekeeping staff was great. The desk staff and maintenance were great. The breakfast had a good selection and was good. There ..."

Reviewed on Sep 8, 2026

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SpringHill Suites by Marriott Florence
Days Inn by Wyndham Florence Near Civic Center

Days Inn by Wyndham Florence Near Civic Center

2.5 out of 5
140 Dunbarton Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,005 reviews)
"The facility looked run down. Got in the room and was not clean the curtain was falling down. The floors LVP flooring was curling up the paint on the back of the bathroom door was peeling off and the door would not close properly. The TV channels where all in spanish had to get that fixed as well. ..."

Reviewed on Sep 10, 2026

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Days Inn by Wyndham Florence Near Civic Center
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

2.5 out of 5
3440 W Radio Dr Florence SC
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.2/10 Wonderful! (1,004 reviews)
"The room was clean and comfortable. The breakfast was hot and plentiful. We would stay here again."

Reviewed on Sep 13, 2026

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Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
See all 98 properties in Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.