Search Deals on
Santo Domingo Vacation Packages

Build your package with 2 more options

Leaving from

Going to

Departing

Returning

Travelers

Room 1

Adults

ChildrenAges 2 to 17

InfantsYounger than 2

Add specific hotel dates

Santo Domingo
Los Santos
Panama
Mexico and Central America
Hotwire.com

Santo Domingo Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Hotel Riu Plaza Panama

5 out of 5

Price was $1,231, price is now $866 per person

$866

per person

Aug 17 - Aug 22

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,712, price is now $978 per person

$978

per person

Aug 17 - Aug 22

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Megapolis Hotel Panamá

4.5 out of 5

Price was $1,449, price is now $1,014 per person

$1,014

per person

Aug 17 - Aug 22

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Casa Mallet by Wynwood House

4 out of 5

Price was $1,644, price is now $1,162 per person

$1,162

per person

Jul 8 - Jul 12

found 17 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Las Clementinas

3.5 out of 5

Price was $1,574, price is now $1,126 per person

$1,126

per person

Aug 10 - Aug 16

found 23 hours ago

Roundtrip flight included

Nassau (NAS) to Panama City (PTY)

Stay at this aparthotel in Panama City. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Boutique Apartments Panamá Coco del Mar

3.5 out of 5

Save 100% on your flight

Price was $5,045, price is now $3,652 per person

$3,652

per person

Jul 20 - Jul 27

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

Centriqo by Wynwood house

3 out of 5

Price was $1,208, price is now $896 per person

$896

per person

Aug 7 - Aug 14

found 4 hours ago

Roundtrip flight included

Tampa (TPA) to Panama City (PTY)

Stay at this apartment in Veracruz. Enjoy free WiFi, air conditioning, and an outdoor pool. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.