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Santa Cruz
Chiriquí Province
Panama
Mexico and Central America
Hotwire.com

Santa Cruz Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Villa Botero By Casa Mojito B&B

3 out of 5

Price was $643, price is now $424 per person

$424

per person

Nov 28 - Dec 1

found 1 day ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3-star golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Farallón Beach are located nearby.

Central Hotel Bocas del Toro

3 out of 5

Price was $3,581, price is now $1,793 per person

$1,793

per person

Dec 27 - Jan 2

found 20 hours ago

Roundtrip flight included

Miami (MIA) to Panama City (PTY)

Stay at this 3-star hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and a marina. Popular attractions Bolivar Park and Bocas del Toro Ferry Terminal are located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,431, price is now $850 per person

$850

per person

Nov 11 - Nov 15

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Mahogany Suites

2 out of 5

Price was $1,520, price is now $1,046 per person

$1,046

per person

Dec 22 - Dec 28

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this hotel in Arraijan. Enjoy free WiFi and an outdoor pool. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Hotel Riu Plaza Panama

5 out of 5

Price was $1,397, price is now $971 per person

$971

per person

Nov 21 - Nov 28

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Casa Fofo

3 out of 5

Price was $1,051, price is now $735 per person

$735

per person

Nov 13 - Nov 20

found 1 day ago

Roundtrip flight included

Fort Lauderdale (FLL) to Panama City (PTY)

Stay at this 3-star guesthouse in San Carlos. Enjoy free WiFi, free parking, and a rooftop terrace. Popular attractions Playa El Palmar and Teta Beach are located nearby.

Casa Mallet by Wynwood House

4 out of 5

Save 100% on your flight

Price was $4,269, price is now $3,033 per person

$3,033

per person

Dec 28 - Jan 3

found 24 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 4-star apartment in Panama City. Enjoy free WiFi, parking (surcharge), and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa Lefevre By Wynwood House

3.5 out of 5

Price was $1,190, price is now $855 per person

$855

per person

Nov 13 - Nov 20

found 22 hours ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this 3.5-star apartment in Las Cumbres. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions El Peñón and Summit Botanical Gardens & Zoo are located nearby.