Search Deals on
Río Sereno Vacation Packages

Build your package with 2 more options

Leaving from

Going to

Departing

Returning

Travelers

Room 1

Adults

ChildrenAges 2 to 17

InfantsYounger than 2

Add specific hotel dates

Río Sereno
Chiriquí Province
Panama
Mexico and Central America
Hotwire.com

Río Sereno Flight + Hotel Packages

Price found within the past 48 hours. Click for updated prices.

Mahogany Suites

2 out of 5

Price was $855, price is now $520 per person

$520

per person

Jan 15 - Jan 19

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this golf hotel in Arraijan. Enjoy free WiFi, a golf course, and an outdoor pool. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Villa Marina Lodge & Condos

3.5 out of 5

Save 100% on your flight

Price was $1,443, price is now $888 per person

$888

per person

Jan 28 - Feb 2

found 10 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Book a stay at this beach inn in Las Escobas del Venado. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff in our reviews. Popular attraction Venao Beach is located nearby.

Central Hotel Panama Casco Viejo

4 out of 5

Save 100% on your flight

Price was $1,274, price is now $787 per person

$787

per person

Feb 21 - Feb 24

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Villa Botero By Casa Mojito B&B

3 out of 5

Price was $947, price is now $645 per person

$645

per person

Feb 14 - Feb 18

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Book a stay at this golf B&B in Rio Hato. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Playa Blanca and Farallón Beach are located nearby.

La Cuadra by Wynwood House

3.5 out of 5

Save 100% on your flight

Price was $1,440, price is now $986 per person

$986

per person

Jan 28 - Feb 2

found 10 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Stay at this condo in Panama City. Enjoy free WiFi, a 24-hour front desk, and cable TV channels. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa La Costa By Wynwood House

3.5 out of 5

Save 100% on your flight

Price was $1,559, price is now $1,071 per person

$1,071

per person

Jan 28 - Feb 2

found 10 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Stay at this apartment in Panama City. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Casa Lefevre By Wynwood House

3.5 out of 5

Price was $1,342, price is now $931 per person

$931

per person

Jan 28 - Feb 2

found 16 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Panama City (PTY)

Stay at this apartment in Las Cumbres. Enjoy free WiFi, cable TV channels, and premium bedding. Popular attractions El Peñón and Summit Botanical Gardens & Zoo are located nearby.

Playa Caracol Residences Vacation Rental

3.5 out of 5

Price was $899, price is now $624 per person

$624

per person

Feb 14 - Feb 18

found 1 day ago

Roundtrip non-stop flight included

Atlanta (ATL) to Panama City (PTY)

Stay at this apartment in Punta Chame. Enjoy free WiFi, free parking, and 2 outdoor pools. Popular attraction Playa Malibú is located nearby.